AC T04649
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ID T04649
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DT 07.08.2001 (created); mas.
DT 18.10.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA ER-beta6
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SY estrogen receptor beta; estrogen receptor beta 1; NR3A2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002763 Esr2.
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CL C0002; CC (rec).
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SZ 485 AA; 54.1 kDa (cDNA) (calc.).
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SQ MTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKS
SQ PWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWS
SQ CEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCG
SQ YRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRP
SQ SMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMW
SQ RSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFGMLLATTARFRELKLQHKEYLCVKAMIL
SQ LNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHV
SQ RHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQ
SQ NLQSQ
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SC translated from EMBL #U81451
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FT 101 172 
SM00399; c4gold.
FT 101 176 
PS51030; NUCLEAR_REC_DBD_2.
FT 102 177 
PF00105; Zinc finger, C4 type (two domains).
FT 131 430 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 255 424 
SM00430; holi.
FT 258 449 
PF00104; Ligand-binding domain of nuclear hormon.
FT 444 451 
AF-2 domain (activation function) [1].
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SF activated by Ras-Raf-1-MAPK kinase and MAPK pathway: therefore phosphorylation at pos. 60 (Serine) is important [1];
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CP (adult): ovary [1].
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FF activates transcription in response to ligand binding (estradiol) [1];
FF affinity for estradiol (Kd 0,5 nM) lower than that of paralog ER-alpha T00259 [1];
FF interaction with transcriptional coactivator SRC-1 T04632 increases transcriptional activity (binding site R01906) both in presence and absence of ligand (estradiol) [1];
FF antiestrogens (4-hydroxytamoxifen, ICI 182,780) block estradiol-dependent transcriptional activity [1];
FF antiestrogen 4-hydroxytamoxifen is just antagonist and no mixed agonist-antagonist like with paralog ER-alpha T00259 [1];
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IN T04632 SRC-1; human, Homo sapiens.
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MX M00959 V$ER_Q6_02.
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BS R01906.
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DR TRANSPATH: MO000021436.
DR EMBL: U81451; MMU81451.
DR UniProtKB: O08537; ESR2_MOUSE.
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RN [1]; RE0016537.
RX PUBMED: 9058381.
RA Tremblay G. B., Tremblay A., Copeland N. G., Gilbert D. J., Jenkins N. A., Labrie F., Giguere V.
RT Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
RL Mol. Endocrinol. 11:353-365 (1997).
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