AC T00259
XX
ID T00259
XX
DT 26.01.1993 (created); hse.
DT 04.09.2014 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA ER-alpha
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SY ER; ESR1; estrogen receptor; NR3A1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006037 Esr1.
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CL C0002; CC (rec); 2.1.1.2.1.
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SF 1H NMR, crystal structure: 2 zinc ions coordinated by 4 Cys within each zinc finger;
SF 2 perpendicular alpha-helices [4] [10];
SF C-terminal transcription activating function (TAF-2): hormone-inducible [8];
XX
FF activates transcription in response to estrogen hormones (e.g. estradiol) [13] [8];
FF affinity for estradiol (Kd 0,2 nM) higher than that of paralog ER-beta T04649 (Kd 0,5 nM) [13];
FF interaction with transcriptional coactivator SRC-1 T04632 increases transcriptional activity (binding site R01906) in response to estradiol [13];
FF antiestrogen ICI 164,384 inhibits DNA-binding by impairing receptor dimerization [6] [7];
FF antiestrogen 4-hydroxytamoxifen functions as mixed agonist-antagonist [13];
XX
IN T27166 BAF57; mouse, Mus musculus.
IN T01318 CBP; mouse, Mus musculus.
IN T00259 ER-alpha; mouse, Mus musculus.
IN T09997 Hsp90; mouse, Mus musculus.
IN T05133 p/CAF; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T04632 SRC-1; human, Homo sapiens.
IN T04639 SRC-1; mouse, Mus musculus.
IN T04638 SRC3; mouse, Mus musculus.
IN T02482 TIF2; mouse, Mus musculus.
XX
MX M01801 V$ERALPHA_01.
MX M07283 V$ERALPHA_Q4.
MX M03547 V$ERALPHA_Q6_01.
MX M03820 V$ERALPHA_Q6_02.
MX M00191 V$ER_Q6.
MX M00959 V$ER_Q6_02.
XX
BS R02150.
BS R00417.
BS R03564.
BS R03565.
BS R61460.
BS R70621.
BS R70622.
BS R70608.
BS R70611.
BS R61280.
BS R62444.
BS R63782.
BS R03563.
BS R70615.
BS R70617.
BS R70619.
BS R71723.
BS R70623.
BS R70599.
BS R62555.
BS R70613.
BS R14214.
BS R01906.
XX
DR TRANSPATH: MO000024810.
DR UniProtKB: P19785;
XX
RN [1]; RE0000065.
RX PUBMED: 2317866.
RA Fawell S. E., Lees J. A., White R., Parker M. G.
RT Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
RL Cell 60:953-962 (1990).
RN [2]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [3]; RE0001755.
RX PUBMED: 1584212.
RA Liu Y., Teng C. T.
RT Estrogen response module of the mouse lactoferrin gene contains overlapping chicken ovalbumin up-stream promoter transcription factor and estrogen receptor-binding elements
RL Mol. Endocrinol. 6:355-364 (1992).
RN [4]; RE0001894.
RX PUBMED: 2247153.
RA Schwabe J. W. R., Neuhaus D., Rhodes D.
RT Solution structure of the DNA-binding domain of the oestrogen receptor
RL Nature 348:458-461 (1990).
RN [5]; RE0002075.
RX PUBMED: 1975094.
RA de Verneuil H., Metzger D.
RT The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation in the DNA binding domain of the protein
RL Nucleic Acids Res. 18:4489-4497 (1990).
RN [6]; RE0002536.
RX PUBMED: 2395882.
RA Fawell S. E., White R., Hoare S., Sydenham M., Page M., Parker M. G.
RT Inhibition of estrogen receptor-DNA binding by the pure antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization
RL Proc. Natl. Acad. Sci. USA 87:6883-6887 (1990).
RN [7]; RE0003769.
RX PUBMED: 1508668.
RA Arbuckle N. D., Dauvois S., Parker M. G.
RT Effects of antioestrogens on the DNA binding activity of oestrogen receptors in vitro
RL Nucleic Acids Res. 29:3839-3844 (1992).
RN [8]; RE0003770.
RX PUBMED: 1372244.
RA Danielian P. S., White R., Lees J. A., Parker M. G.
RT Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
RL EMBO J. 11:1025-1033 (1992).
RN [9]; RE0003774.
RX PUBMED: 3422428.
RA Golding T. S., Korach K.
RT Nuclear estrogen receptor molecular heterogenity in the mouse uterus
RL Proc. Natl. Acad. Sci. USA 85:69-73 (1988).
RN [10]; RE0003777.
RX PUBMED: 8221895.
RA Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D.
RT The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements
RL Cell 75:567-578 (1993).
RN [11]; RE0003780.
RX PUBMED: 3882696.
RA Lubahn D. B., McCarty jr K. S., McCarty sr K. S.
RT Electrophoretic characterization of purified bovine, porcine, murine, rat, and human uterine estrogen receptors
RL J. Biol. Chem. 260:2515-2526 (1985).
RN [12]; RE0016449.
RX PUBMED: 10428842.
RA Hong H., Yang L., Stallcup M. R.
RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
RL J. Biol. Chem. 274:22618-22626 (1999).
RN [13]; RE0016537.
RX PUBMED: 9058381.
RA Tremblay G. B., Tremblay A., Copeland N. G., Gilbert D. J., Jenkins N. A., Labrie F., Giguere V.
RT Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
RL Mol. Endocrinol. 11:353-365 (1997).
RN [14]; RE0031549.
RX PUBMED: 11477071.
RA Teyssier C., Belguise K., Galtier F., Chalbos D.
RT Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
RL J. Biol. Chem. 276:36361-9 (2001).
RN [15]; RE0035802.
RX PUBMED: 12374744.
RA Wang R. A., Mazumdar A., Vadlamudi R. K., Kumar R.
RT P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
RL EMBO J. 21:5437-5447 (2002).
RN [16]; RE0036017.
RX PUBMED: 14751567.
RA Longo M., Brama M., Marino M., Bernardini S., Korach K. S., Wetsel W. C., Scandurra R., Faraggiana T., Spera G., Baron R., Teti A., Migliaccio S.
RT Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
RL Bone 34:100-111 (2004).
RN [17]; RE0047326.
RX PUBMED: 15538384.
RA Tateishi Y., Kawabe Y., Chiba T., Murata S., Ichikawa K., Murayama A., Tanaka K., Baba T., Kato S., Yanagisawa J.
RT Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.
RL EMBO J. 23:4813-4823 (2004).
RN [18]; RE0050034.
RX PUBMED: 17130235.
RA Bao J., Cao C., Zhang X., Jiang F., Nicosia S. V., Bai W.
RT Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65.
RL Mol. Cell. Biol. 27:1321-1333 (2007).
RN [19]; RE0064219.
RX PUBMED: 12881205.
RA Muller-Delp J. M., Lubahn D. B., Nichol K. E., Philips B. J., Price E. M., Curran E. M., Laughlin M. H.
RT Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-alpha-deficient mice.
RL Am. J. Physiol. Heart Circ. Physiol. 285:H2150-7 (2003).
RN [20]; RE0065548.
RX PUBMED: 19574399.
RA Chen J., An B. S., Cheng L., Hammond G. L., Leung P. C.
RT Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
RL Endocrinology 150:4583-4593 (2009).
RN [21]; RE0069471.
RX PUBMED: 15602573.
RA Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
RT WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.
RL Oncogene 23:9314-9325 (2004).
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