AC T04638
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ID T04638
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DT 24.07.2001 (created); mas.
DT 10.01.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA SRC3
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SY NCOA-3; NCOA3; nuclear receptor coactivator 3; p/CIP; P300/CBP/co-integrator protein; SRC-3; steroid receptor coactivator-3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002756 Ncoa3.
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CL C0010; bHLH; 1.2.5.3.3.
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SF coactivator for the steroid hormone receptor superfamily [2];
SF contains several NR box motifs within the nuclear receptor interacting domain: important for interaction with cognate nuclear receptors in ligand-bound status (via AF-2 domain) [2] [1];
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IN T01795 AhR; human, Homo sapiens.
IN T01318 CBP; mouse, Mus musculus.
IN T00259 ER-alpha; mouse, Mus musculus.
IN T16015 ER-beta; Mammalia.
IN T06175 ERR2; mouse, Mus musculus.
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DR TRANSPATH: MO000028471.
DR UniProtKB: O09000;
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RN [1]; RE0006908.
RX PUBMED: 9430642.
RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H.
RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
RN [2]; RE0016476.
RX PUBMED: 10713439.
RA Leo C., Chen J. D.
RT The SRC family of nuclear receptor coactivators
RL Gene 245:1-11 (2000).
RN [3]; RE0048217.
RX PUBMED: 11971985.
RA Wu R. C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
RL Mol. Cell. Biol. 22:3549-3561 (2002).
RN [4]; RE0065548.
RX PUBMED: 19574399.
RA Chen J., An B. S., Cheng L., Hammond G. L., Leung P. C.
RT Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
RL Endocrinology 150:4583-4593 (2009).
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