TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01318 XX ID T01318 XX DT 23.10.1994 (created); ewi. DT 14.03.2016 (updated); vis. CO Copyright (C), QIAGEN. XX FA CBP XX SY AW558298; CBP; CBP/p300; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; p300/CBP. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005950 Crebbp. XX SF interacts with CREB T00163 which is phosphorylated by PKA, KD = 0.67 uM [1] [6]; SF trans-activation by the C-terminal part which interacts with TFIIB T00818 [2]; SF for interacting and coactivating with c-Jun T00131, Ser-63 and -73 of c-Jun are essential [8]; SF interaction with c-Myb T00138 is phosphorylation-independent [3]; SF binding to E1A competes with binding to E2F [4]; SF interaction with E1A represses the activating function of CBP [3]; SF significant sequence similarity with p300 T01427 [7]; SF interaction with SRCAP T04151 enhances the ability to activate transcription [11]; SF N-terminus is involved in direct interactions with CREST T05824 [12]; SF N-terminus is required for interactions with RelA [13]; SF C-terminus interacts directly with STAT1 [13]; XX FF coactivator of CREB T00163 [1]; FF co-activator of c-Myb T00138 [3]; FF co-activator of E2F [4]; FF co-activator of Cdx-2 T02002; FF co-activator of ARIX T03960 [10]; FF co-activator of Pmx2b T03961 [10]; FF co-activation of CREB depends on a cAMP-dependent step which cannot be substituted by a calcium / diacylglycerol-dependent pathway [9]; FF interacts directly with CREST T05824, which is important for calcium-dependent transactivation [12]; FF interacts simultaneously with STAT1 and RelA thus providing a mechanism for their synergistic action [13]; FF CBP potentiates GLI3 T00331- induced transactivation [14]; XX IN T06598 AML-1; mouse, Mus musculus. IN T01397 c-Ets-2; mouse, Mus musculus. IN T00122 c-Fos; mouse, Mus musculus. IN T00131 c-Jun; mouse, Mus musculus. IN T00138 c-Myb; mouse, Mus musculus. IN T02002 Cdx-2; mouse, Mus musculus. IN T00163 CREB-A; human, Homo sapiens. IN T09440 CREB1; mouse, Mus musculus. IN T00989 CREB; mouse, Mus musculus. IN T05824 CREST; rat, Rattus norvegicus. IN T00259 ER-alpha; mouse, Mus musculus. IN T00305 GATA-1; mouse, Mus musculus. IN T00331 gli3; human, Homo sapiens. IN T01733 HOXB6; mouse, Mus musculus. IN T27548 IRF-3; human, Homo sapiens. IN T10644 MTF-1; mouse, Mus musculus. IN T05299 NR1B1; human, Homo sapiens. IN T05870 p52; mouse, Mus musculus. IN T00671 p53; human, Homo sapiens. IN T01806 p53; mouse, Mus musculus. IN T17772 p53{pS15}; human, Homo sapiens. IN T31792 p53{pS20}; human, Homo sapiens. IN T03960 PMX2A; rat, Rattus norvegicus. IN T03961 PMX2B; human, Homo sapiens. IN T00694 PPARalpha; mouse, Mus musculus. IN T00595 RelA-p65; mouse, Mus musculus. IN T04095 Smad2-L; human, Homo sapiens. IN T04431 Smad3; rat, Rattus norvegicus. IN T04638 SRC3; mouse, Mus musculus. IN T04151 SRCAP; human, Homo sapiens. IN T01574 STAT3; mouse, Mus musculus. IN T01580 STAT6; human, Homo sapiens. IN T01581 STAT6; mouse, Mus musculus. IN T00818 TFIIB; human, Homo sapiens. XX BS R20300. BS R60769. XX DR TRANSPATH: MO000019106. DR UniProtKB: P45481; XX RN [1]; RE0001914. RX PUBMED: 8413673. RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M. R., Goodman R. H. RT Phosphorylated CREB binds specifically to the nuclear protein CBP RL Nature 365:855-859 (1993). RN [2]; RE0005257. RX PUBMED: 7913207. RA Kwok R. P., Lundblad J. R., Chrivia J. C., Richards J. P., Baechinger H. P., Brennan R. G., Roberts S. G., Green M. R., Goodman R. H. RT Nuclear protein CBP is a coactivator for the transcription factor CREB RL Nature 370:223-226 (1994). RN [3]; RE0005628. RX PUBMED: 8598284. RA Dai P., Akimaru H., Tanaka Y., Hou D.-X., Yasukawa T., Kanei-Ishii C., Takahashi T., Ishii S. RT CBP as a transcriptional coactivator of c-Myb RL Genes Dev. 10:528-540 (1996). RN [4]; RE0005629. RX PUBMED: 8932363. RA Trouche D., Cook A., Kouzarides T. RT The CBP co-activator stimulates E2F1/DP1 activity RL Nucleic Acids Res. 24:4139-4145 (1996). RN [5]; RE0005630. RX PUBMED: 7588605. RA Bannister A. J., Kouzarides T. RT CBP-induced stimulation of c-Fos activity is abrogated by E1A RL EMBO J. 14:4758-4762 (1995). RN [6]; RE0005631. RX PUBMED: 7870179. RA Lundblad J. R., Kwok R. P. S., Laurance M. E., Harter M. L., Goodman R. H. RT Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP RL Nature 374:85-88 (1995). RN [7]; RE0005632. RX PUBMED: 7523245. RA Eckner R., Ewen M. E., Newsome D., Gerdes M., DeCapiro J. A., Lawrence J. B., Livingston D. M. RT Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor RL Genes Dev. 8:869-884 (1994). RN [8]; RE0005633. RX PUBMED: 8545107. RA Bannister A. J., Oehler T., Wilhelm D., Angel P., Kouzarides T. RT Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro RL Oncogene 11:2509-2514 (1995). RN [9]; RE0006681. RX PUBMED: 7479832. RA Brindle P., Nakajima T., Montminy M. RT Multpile protein kinase A-regulated events are required for transcriptional induction by cAMP RL Proc. Natl. Acad. Sci. USA 92:10521-10525 (1995). RN [10]; RE0015252. RX PUBMED: 10644760. RA Swanson D. J., Adachi M., Lewis E. J. RT The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein RL J. Biol. Chem. 275:2911-2923 (2000). RN [11]; RE0015534. RX PUBMED: 10347196. RA Johnston H., Kneer J., Chackalaparampil I., Yaciuk P., Chrivia J. RT Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein RL J. Biol. Chem. 274:16370-16376 (1999). RN [12]; RE0023768. RX PUBMED: 14716005. RA Aizawa H., Hu S. C., Bobb K., Balakrishnan K., Ince G., Gurevich I., Cowan M., Ghosh A. RT Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. RL Science 303:197-202 (2004). RN [13]; RE0024015. RX PUBMED: 12403783. RA Hiroi M., Ohmori Y. RT The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. RL J. Biol. Chem. 278:651-660 (2003). RN [14]; RE0025306. RX PUBMED: 10075717. RA Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S. RT Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. RL J. Biol. Chem. 274:8143-8152 (1999). RN [15]; RE0030381. RX PUBMED: 13678586. RA Marambaud P., Wen P. H., Dutt A., Shioi J., Takashima A., Siman R., Robakis N. K. RT A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. RL Cell 114:635-45 (2003). RN [16]; RE0038960. RX PUBMED: 10722728. RA Yahata T., de Caestecker M. P., Lechleider R. J., Andriole S., Roberts A. B., Isselbacher K. J., Shioda T. RT The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors RL J. Biol. Chem. 275:8825-34 (2000). RN [17]; RE0039427. RX PUBMED: 9606182. RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M. RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation RL EMBO J. 17:2994-3004 (1998). RN [18]; RE0042428. RX PUBMED: 11799127. RA Emelyanov A. V., Kovac C. R., Sepulveda M. A., Birshtein B. K. RT The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells RL J. Biol. Chem. 277:11156-64 (2002). RN [19]; RE0048566. RX PUBMED: 15572696. RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J. RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. RL Mol. Cell. Biol. 24:10954-10964 (2004). RN [20]; RE0049146. RX PUBMED: 16287841. RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C. RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. RL Mol. Cell. Biol. 25:10235-10250 (2005). RN [21]; RE0049976. RX PUBMED: 17434128. RA Huang W. C., Ju T. K., Hung M. C., Chen C. C. RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. RL Mol. Cell 26:75-87 (2007). RN [22]; RE0050322. RX PUBMED: 16768463. RA Hostetler H. A., Kier A. B., Schroeder F. RT Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha). RL Biochemistry 45:7669-7681 (2006). RN [23]; RE0065548. RX PUBMED: 19574399. RA Chen J., An B. S., Cheng L., Hammond G. L., Leung P. C. RT Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs. RL Endocrinology 150:4583-4593 (2009). RN [24]; RE0069578. RX PUBMED: 20962272. RA Lee C. W., Ferreon J. C., Ferreon A. C., Arai M., Wright P. E. RT Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. RL Proc. Natl. Acad. Sci. USA 107:19290-19295 (2010). XX //