TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01581 XX ID T01581 XX DT 24.11.1995 (created); ewi. DT 17.06.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA STAT6 XX SY signal transducer and activator of transcription 6; STAT-6. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005103 Stat6. XX CL C0039; STAT; XX CP hemopoietic cell lines (mainly). XX FF STAT6 is activated by IL-4 and IL-13 [3]; FF Increases expression of mouse Germline epsilon (Ce) gene [9]; FF mediates response to IL-3 and IL-4, which induce tyrosine phosphorylation [1]; FF no induction by IL-2, IL-12, erythropoietin [1]; XX IN T01318 CBP; mouse, Mus musculus. IN T25632 litaf; mouse, Mus musculus. XX MX M00494 V$STAT6_01. MX M00500 V$STAT6_02. MX M07133 V$STAT6_03. MX M07066 V$STAT6_Q4. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R07553. BS R07554. BS R07555. BS R07556. BS R07557. BS R07558. BS R07559. BS R07560. BS R07561. BS R07562. BS R07563. BS R07564. BS R07565. BS R07566. BS R14546. BS R14547. BS R24094. BS R11183. BS R35848. BS R23774. BS R26933. BS R04223. BS R13215. BS R30081. BS R25420. BS R32207. BS R33475. BS R21520. BS R21521. BS R21522. BS R21523. BS R26248. BS R26249. BS R26250. BS R33965. BS R35886. BS R26945. BS R73952. BS R29486. BS R64623. BS R68418. BS R30851. BS R26520. BS R70455. BS R70457. BS R70456. BS R57187. BS R25574. BS R19616. BS R04650. XX DR TRANSPATH: MO000013131. DR TRANSCOMPEL: C00183. DR TRANSCOMPEL: C00307. DR TRANSCOMPEL: C00311. DR TRANSCOMPEL: C00316. DR TRANSCOMPEL: C00317. DR TRANSCOMPEL: C00565. DR UniProtKB: P52633; XX RN [1]; RE0003483. RX PUBMED: 7760829. RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N. RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis RL Mol. Cell. Biol. 15:3336-3343 (1995). RN [2]; RE0047376. RX PUBMED: 15793005. RA Tang X., Marciano D. L., Leeman S. E., Amar S. RT LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. RL Proc. Natl. Acad. Sci. USA 102:5132-5137 (2005). RN [3]; RE0048479. RX PUBMED: 16237061. RA Yamada A., Sheikh F., Niimi T., DeMayo F. J., Keegan A. D., Donnelly R. P., Kimura S. RT Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. RL J. Immunol. 175:5708-5715 (2005). RN [4]; RE0052705. RX PUBMED: 15087305. RA King N. E., Zimmermann N., Pope S. M., Fulkerson P. C., Nikolaidis N. M., Mishra A., Witte D. P., Rothenberg M. E. RT Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. RL Am. J. Respir. Cell Mol. Biol. 31:257-265 (2004). RN [5]; RE0065726. RX PUBMED: 16698929. RA Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B. M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J. RT Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. RL Proc. Natl. Acad. Sci. USA 103:8137-8142 (2006). RN [6]; RE0067764. RX PUBMED: 16547273. RA Fritz D. K., Kerr C., Tong L., Smyth D., Richards C. D. RT Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6. RL J. Immunol. 176:4352-4360 (2006). RN [7]; RE0068899. RX PUBMED: 10491204. RA Friedrich K., Kammer W., Erhardt I., Brandlein S., Arnold S., Sebald W. RT The two subunits of the interleukin-4 receptor mediate independent and distinct patterns of ligand endocytosis. RL Eur. J. Biochem. 265:457-465 (1999). RN [8]; RE0070066. RX PUBMED: 20696842. RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F. RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. RL Mol. Cell. Biol. 30:4877-4889 (2010). RN [9]; RE0064455. RX PUBMED: 9647237. RA Linehan L. A., Warren W. D., Thompson P. A., Grusby M. J., Berton M. T. RT STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. RL J. Immunol. 161:302-310 (1998). XX //