AC T04431
XX
ID T04431
XX
DT 17.04.2001 (created); dkl.
DT 22.06.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA Smad3
XX
SY Smad-3.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G001976 Smad3.
XX
CL C0041; SMAD; 7.1.1.1.3.
XX
FF C-terminal region (MH2 domain) and conserved glycin residue (AA 379) in L3 loop, which is proposed to be involved in protein-protein interaction, are required for the self-stimulatory activity [3];
FF MH1 domain and four lysin residues at positions 40, 41, 43 and 44 in this domain are involved in the inhibitory activity of SMAD-3 [3];
FF is able to associate with FAST-2.ARE complex and this association is dependent on FAST-2 [3];
FF interacts with p300/CBP [4];
FF co-activation of PAI-1 promoter together with Smad4 T04292 and p300 [4];
XX
IN T14513 beta-catenin; Mammalia.
IN T01318 CBP; mouse, Mus musculus.
IN T14202 GKLF; Mammalia.
IN T15112 GKLF; rat, Rattus norvegicus.
IN T01427 p300; human, Homo sapiens.
IN T00882 VDR; rat, Rattus norvegicus.
XX
MX M00701 V$SMAD3_Q6.
MX M01888 V$SMAD3_Q6_01.
MX M07429 V$SMAD3_Q6_02.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R10004.
BS R23224.
BS R27486.
BS R23546.
BS R30352.
BS R30498.
BS R68478.
BS R41627.
BS R41661.
BS R35004.
BS R35007.
BS R24152.
BS R24154.
BS R31183.
BS R31501.
BS R73581.
XX
DR TRANSPATH: MO000028284.
DR UniProtKB: P84025;
XX
RN [1]; RE0006456.
RX PUBMED: 8917532.
RA Chen Y., Lebrun J. J., Vale W.
RT Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins
RL Proc. Natl. Acad. Sci. USA 93:12992-12997 (1996).
RN [2]; RE0015115.
RX PUBMED: 10767528.
RA Dick A., Mayr T., Bauer H., Meier A., Hammerschmidt M.
RT Cloning and characterization of zebrafish smad2, smad3 and smad4
RL Gene 246:69-80 (2000).
RN [3]; RE0015871.
RX PUBMED: 10531318.
RA Nagarajan R. P., Liu J., Chen Y.
RT Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding.
RL J. Biol. Chem. 274:31229-31235 (1999).
RN [4]; RE0016417.
RX PUBMED: 9679056.
RA Janknecht R., Wells N. J., Hunter T.
RT TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.
RL Genes Dev. 12:2114-2119 (1998).
RN [5]; RE0033680.
RX PUBMED: 12702545.
RA Hu B., Wu Z., Phan S. H.
RT Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression.
RL Am. J. Respir. Cell Mol. Biol. 29:397-404 (2003).
RN [6]; RE0035990.
RX PUBMED: 14982932.
RA Selvamurugan N., Kwok S., Alliston T., Reiss M., Partridge N. C.
RT Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2.
RL J. Biol. Chem. 279:19327-19334 (2004).
RN [7]; RE0053353.
RX PUBMED: 11592788.
RA Aschenbrenner J. K., Sollinger H. W., Becker B. N., Hullett D. A.
RT 1,25-(OH(2))D(3) alters the transforming growth factor beta signaling pathway in renal tissue.
RL J. Surg. Res. 100:171-175 (2001).
RN [8]; RE0053736.
RX PUBMED: 17942918.
RA Jin W., Yun C., Kim H. S., Kim S. J.
RT TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling.
RL Cancer Res. 67:9869-9877 (2007).
RN [9]; RE0053874.
RX PUBMED: 16740974.
RA de Guise C., Lacerte A., Rafiei S., Reynaud R., Roy M., Brue T., Lebrun J. J.
RT Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner.
RL Endocrinology 147:4351-4362 (2006).
RN [10]; RE0064277.
RX PUBMED: 17125875.
RA Weng H., Mertens P. R., Gressner A. M., Dooley S.
RT IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads.
RL J. Hepatology 46:295-303 (2007).
RN [11]; RE0064958.
RX PUBMED: 18511507.
RA Chen Y. J., Lee M. T., Yao H. C., Hsiao P. W., Ke F. C., Hwang J. J.
RT Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.
RL Endocrinology 149:4658-4668 (2008).
RN [12]; RE0067098.
RX PUBMED: 20375011.
RA Li H. X., Han M., Bernier M., Zheng B., Sun S. G., Su M., Zhang R., Fu J. R., Wen J. K.
RT Kruppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells.
RL J. Biol. Chem. 285:17846-17856 (2010).
RN [13]; RE0069194.
RX PUBMED: 21245987.
RA Gressner O. A., Peredniene I., Gressner A. M.
RT Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein.
RL World J. Gastroenterol. 17:151-163 (2011).
XX
//