TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T14513 XX ID T14513 XX DT 10.03.2005 (created); nvo. DT 28.04.2016 (updated); mom. CO Copyright (C), QIAGEN. XX FA beta-catenin XX SY CTNNB; CTNNB1. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T15601 AR; Mammalia. IN T34676 ash2l; human, Homo sapiens. IN T16987 BRG1; Mammalia. IN T08499 CBP; mouse, Mus musculus. IN T15118 CBP; Mammalia. IN T00241 Egr-1; human, Homo sapiens. IN T16596 foxo4; Mammalia. IN T14002 GKLF; mouse, Mus musculus. IN T14202 GKLF; Mammalia. IN T21852 HDAC1; Mammalia. IN T00433 ITF-2; human, Homo sapiens. IN T33787 Kaiso; Mammalia. IN T09551 LEF-1; Mammalia. IN T16141 LEF-1; human, Homo sapiens. IN T08498 Nur77-isoform1; human, Homo sapiens. IN T10542 p300; mouse, Mus musculus. IN T23091 p300; Mammalia. IN T28503 pitx2a; Mammalia. IN T09964 RXR-alpha; Mammalia. IN T19219 Sall1-isoform1; human, Homo sapiens. IN T10138 SF-1; Mammalia. IN T10783 Smad1; Mammalia. IN T04096 Smad3-isoform1; human, Homo sapiens. IN T04431 Smad3; rat, Rattus norvegicus. IN T13998 Smad4; Mammalia. IN T15014 SNA; human, Homo sapiens. IN T10914 Sox-9; Mammalia. IN T01002 TCF-1; human, Homo sapiens. IN T16692 TCF-1; Mammalia. IN T16693 TCF-3; Mammalia. IN T02918 TCF-4; human, Homo sapiens. IN T16010 TCF-4; Mammalia. IN T08482 VDR-isoform1; human, Homo sapiens. IN T25956 YAP-isoform2; human, Homo sapiens. IN T22876 YAP; human, Homo sapiens. XX MX M03539 V$BETACATENIN_Q3. MX M07376 V$BETACATENIN_Q3_01. MX M07035 V$BETACATENIN_Q6. MX M07599 V$BETACATENIN_Q6_01. XX BS R72888. BS R72889. BS R66716. BS R66717. BS R66719. BS R66720. BS R24603. BS R58465. BS R58478. BS R58483. BS R58484. BS R58485. BS R58487. BS R72893. XX DR TRANSPATH: MO000047105. XX RN [1]; RE0014134. RX PUBMED: 10027409. RA Wielenga V.J., Smits R., Korinek V., Smit L., Kielman M., Fodde R., Clevers H., Pals S. T. RT Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway RL Am. J. Pathol. 154:515-523 (1999). RN [2]; RE0014255. RX PUBMED: 10223208. RA Mei J. M., Hord N. G., Winterstein D. F., Donald S. P., Phang J. M. RT Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc RL Carcinogenesis 20:737-740 (1999). RN [3]; RE0018458. RX PUBMED: 10477752. RA Espada J., Perez-Moreno M., Braga V. M., Rodriguez-Viciana P., Cano A. RT H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes RL J. Cell Biol. 146:967-980 (1999). RN [4]; RE0018555. RX PUBMED: 10074433. RA Hart M., Concordet J. P., Lassot I., Albert I., del los Santos R., Durand H., Perret C., Rubinfeld B., Margottin F., Benarous R., Polakis P. RT The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell RL Curr. Biol. 25:207-210 (1999). RN [5]; RE0020775. RX PUBMED: 11477086. RA Meng X., Poon R., Zhang X., Cheah A., Ding Q., Hui C. C., Alman B. RT Suppressor of fused negatively regulates beta-catenin signaling RL J. Biol. Chem. 276:40113-40119 (2001). RN [6]; RE0022023. RX PUBMED: 9554852. RA Behrens J., Jerchow B. A., Wurtele M., GrimmJ., Asbrand C., Wirtz R., Kuhl M., Wedlich D., Birchmeier W. RT Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta RL Science 280:596-599 (1998). RN [7]; RE0023647. RX PUBMED: 12511557. RA Mak B. C., Takemaru K., Kenerson H. L., Moon R. T., Yeung R. S. RT The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. RL J. Biol. Chem. 278:5947-5951 (2003). RN [8]; RE0023725. RX PUBMED: 12556497. RA Ishitani T., Ninomiya-Tsuji J., Matsumoto K. RT Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. RL Mol. Cell. Biol. 23:1379-1389 (2003). RN [9]; RE0024454. RX PUBMED: 12771132. RA Xiao J. H., Ghosn C., Hinchman C., Forbes C., Wang J., Snider N., Cordrey A., Zhao Y., Chandraratna R. A. RT Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway. RL J. Biol. Chem. 278:29954-29962 (2003). RN [10]; RE0024487. RX PUBMED: 9742093. RA Rosato R., Veltmaat J. M., Groffen J., Heisterkamp N. RT Involvement of the tyrosine kinase fer in cell adhesion. RL Mol. Cell. Biol. 18:5762-5770 (1998). RN [11]; RE0024548. RX PUBMED: 15063782. RA Kim S. I., Park C. S., Lee M. S., Kwon M. S., Jho E. H., Song W. K. RT Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. RL Biochem. Biophys. Res. Commun. 317:478-483 (2004). RN [12]; RE0024619. RX PUBMED: 10747853. RA Takeda K., Yasumoto K., Takada R., Takada S., Watanabe K., Udono T., Saito H., Takahashi K., Shibahara S. RT Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a. RL J. Biol. Chem. 275:14013-14016 (2000). RN [13]; RE0025653. RX PUBMED: 11179419. RA Zimmermann P., Tomatis D., Rosas M., Grootjans J., Leenaerts I., Degeest G., Reekmans G., Coomans C., David G. RT Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. RL Mol. Biol. Cell 12:339-50 (2001). RN [14]; RE0025813. RX PUBMED: 15031118. RA Israsena N., Hu M., Fu W., Kan L., Kessler J. A. RT The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. RL Dev. Biol. 268:220-31 (2004). RN [15]; RE0025980. RX PUBMED: 9707618. RA Tanaka S., Akiyoshi T., Mori M., Wands J. R., Sugimachi K. RT A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. RL Proc. Natl. Acad. Sci. USA 95:10164-9 (1998). RN [16]; RE0026700. RX PUBMED: 10980594. RA Roth W., Wild-Bode C., Platten M., Grimmel C., Melkonyan H. S., Dichgans J., Weller M. RT Secreted frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells RL Oncogene 19:4210-20 (2000). RN [17]; RE0027413. RX PUBMED: 11136230. RA Meigs T. E., Fields T. A., McKee D. D., Casey P. J. RT Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. RL Proc. Natl. Acad. Sci. USA 98:519-524 (2001). RN [18]; RE0027600. RX PUBMED: 11244511. RA Tan C., Costello P., Sanghera J., Dominguez D., Baulida J., de Herreros A. G., Dedhar S. RT Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. RL Oncogene 20:133-40 (2001). RN [19]; RE0027738. RX PUBMED: 11266469. RA Soriano S., Kang D. E., Fu M., Pestell R., Chevallier N., Zheng H., Koo E. H. RT Presenilin 1 Negatively Regulates beta-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of beta-Amyloid Precursor Protein and Notch Processing. RL J. Cell Biol. 152:785-94 (2001). RN [20]; RE0027798. RX PUBMED: 10462517. RA Ilan N., Mahooti S., Rimm D. L., Madri J. A. RT PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. RL J. Cell Sci. 112:3005-3014 (1999). RN [21]; RE0028692. RX PUBMED: 11328805. RA Adam L., Vadlamudi R. K., McCrea P., Kumar R. RT Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. RL J. Biol. Chem. 276:28443-50 (2001). RN [22]; RE0028789. RX PUBMED: 11486025. RA Danilkovitch-Miagkova A., Miagkov A., Skeel A., Nakaigawa N., Zbar B., Leonard E. J. RT Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. RL Mol. Cell. Biol. 21:5857-68 (2001). RN [23]; RE0028824. RX PUBMED: 11713224. RA Helmbrecht K., Kispert A., von Wasielewski R., Brabant G. RT Identification of a Wnt/beta-Catenin Signaling Pathway in Human Thyroid Cells. RL Endocrinology 142:5261-6 (2001). RN [24]; RE0029344. RX PUBMED: 11912492. RA Jimbo T., Kawasaki Y., Koyama R., Sato R., Takada S., Haraguchi K., Akiyama T. RT Identification of a link between the tumour suppressor APC and the kinesin superfamily. RL Nat. Cell Biol. 4:323-7 (2002). RN [25]; RE0029351. RX PUBMED: 11821434. RA Laura R. P., Witt A. S., Held H. A., Gerstner R., Deshayes K., Koehler M. F., Kosik K. S., Sidhu S. S., Lasky L. A. RT The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. RL J. Biol. Chem. 277:12906-14 (2002). RN [26]; RE0029393. RX PUBMED: 11168805. RA Halama T., Groger M., Pillinger M., Staffler G., Prager E., Stockinger H., Holnthoner W., Lechleitner S., Wolff K., Petzelbauer P. RT Platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin cooperatively regulate fibroblast growth factor-induced modulations of adherens junction functions. RL J. Invest. Dermatol 116:110-7 (2001). RN [27]; RE0029435. RX PUBMED: 11527961. RA Lamberti C., Lin K. M., Yamamoto Y., Verma U., Verma I. M., Byers S., Gaynor R. B. RT Regulation of beta-catenin function by the IkappaB kinases. RL J. Biol. Chem. 276:42276-86 (2001). RN [28]; RE0029454. RX PUBMED: 11950845. RA Schroeder J. A., Adriance M. C., McConnell E. J., Thompson M. C., Pockaj B., Gendler S. J. RT ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. RL J. Biol. Chem. 277:22692-8 (2002). RN [29]; RE0030316. RX PUBMED: 12810642. RA Easwaran V., Lee S. H., Inge L., Guo L., Goldbeck C., Garrett E., Wiesmann M., Garcia P. D., Fuller J. H., Chan V., Randazzo F., Gundel R., Warren R. S., Escobedo J., Aukerman S. L., Taylor R. N., Fantl W. J. RT beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. RL Cancer Res. 63:3145-53 (2003). RN [30]; RE0030476. RX PUBMED: 12192039. RA Kusano S., Raab-Traub N. RT I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. RL Mol. Cell. Biol. 22:6393-405 (2002). RN [31]; RE0030725. RX PUBMED: 12805222. RA Hocevar B. A., Mou F., Rennolds J. L., Morris S. M., Cooper J. A., Howe P. H. RT Regulation of the Wnt signaling pathway by disabled-2 (Dab2). RL EMBO J. 22:3084-94 (2003). RN [32]; RE0030782. RX PUBMED: 12151522. RA Coussen F., Normand E., Marchal C., Costet P., Choquet D., Lambert M., Mege R. M., Mulle C. RT Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. RL J. Neurosci. 22:6426-36 (2002). RN [33]; RE0030944. RX PUBMED: 14747478. RA Golan T., Yaniv A., Bafico A., Liu G., Gazit A. RT The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. RL J. Biol. Chem. 279:14879-88 (2004). RN [34]; RE0031188. RX PUBMED: 10873669. RA Kawajiri A., Itoh N., Fukata M., Nakagawa M., Yamaga M., Iwamatsu A., Kaibuchi K. RT Identification of a novel beta-catenin-interacting protein. RL Biochem. Biophys. Res. Commun. 273:712-7 (2000). RN [35]; RE0031430. RX PUBMED: 14695187. RA Feng Y., Lee N., Fearon E. R. RT TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. RL Cancer Res. 63:8726-34 (2003). RN [36]; RE0031565. RX PUBMED: 14638683. RA Li H., Kim J. H., Koh S. S., Stallcup M. R. RT Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. RL J. Biol. Chem. 279:4212-20 (2004). RN [37]; RE0031743. RX PUBMED: 11792709. RA Yang F., Li X., Sharma M., Sasaki C. Y., Longo D. L., Lim B., Sun Z. RT Linking beta-catenin to androgen-signaling pathway. RL J. Biol. Chem. 277:11336-44 (2002). RN [38]; RE0031757. RX PUBMED: 11526479. RA Morali O. G., Delmas V., Moore R., Jeanney C., Thiery J. P., Larue L. RT IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. RL Oncogene 20:4942-50 (2001). RN [39]; RE0032212. RX PUBMED: 12571228. RA Duchesne C., Charland S., Asselin C., Nahmias C., Rivard N. RT Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells. RL J. Biol. Chem. 278:14274-83 (2003). RN [40]; RE0032226. RX PUBMED: 15013427. RA Shindo M., Chaudhary P. M. RT The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. RL Biochem. Biophys. Res. Commun. 315:73-8 (2004). RN [41]; RE0032287. RX PUBMED: 10425198. RA Hiscox S., Jiang W. G. RT Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells. RL Biochem. Biophys. Res. Commun. 261:406-11 (1999). RN [42]; RE0036496. RX PUBMED: 11025210. RA Sheth B., Fontaine J. J., Ponza E., McCallum A., Page A., Citi S., Louvard D., Zahraoui A., Fleming T. P. RT Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction RL Mech. Dev. 97:93-104 (2000). RN [43]; RE0036727. RX PUBMED: 10861224. RA Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. RT Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins RL Biochem. J. 349:159-167 (2000). RN [44]; RE0036733. RX PUBMED: 9521872. RA Kido M., Obata S., Tanihara H., Rochelle J. M., Seldin M. F., Taketani S., Suzuki S. T. RT Molecular properties and chromosomal location of cadherin-8 RL Genomics 48:186-94 (1998). RN [45]; RE0037059. RX PUBMED: 10769211. RA Hanakawa Y., Amagai M., Shirakata Y., Sayama K., Hashimoto K. RT Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes RL J. Cell Sci. 113:1803-11 (2000). RN [46]; RE0037223. RX PUBMED: 14595118. RA Bharti S., Handrow-Metzmacher H., Zickenheiner S., Zeitvogel A., Baumann R., Starzinski-Powitz A. RT Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells RL Mol. Biol. Cell 15:397-406 (2004). RN [47]; RE0037242. RX PUBMED: 8663237. RA Fuchs M., Muller T., Lerch M. M., Ullrich A. RT Association of human protein-tyrosine phosphatase kappa with members of the armadillo family RL J. Biol. Chem. 271:16712-9 (1996). RN [48]; RE0037363. RX PUBMED: 12138115. RA Karasawa T., Yokokura H., Kitajewski J., Lombroso P. J. RT Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling RL J. Biol. Chem. 277:37479-86 (2002). RN [49]; RE0037525. RX PUBMED: 12384519. RA Takahashi M., Fujita M., Furukawa Y., Hamamoto R., Shimokawa T., Miwa N., Ogawa M., Nakamura Y. RT Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis RL Cancer Res. 62:5651-6 (2002). RN [50]; RE0037531. RX PUBMED: 12657639. RA Wakabayashi M., Ito T., Mitsushima M., Aizawa S., Ueda K., Amachi T., Kioka N. RT Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact RL J. Biol. Chem. 278:21709-14 (2003). RN [51]; RE0037558. RX PUBMED: 12712206. RA Takemaru K., Yamaguchi S., Lee Y. S., Zhang Y., Carthew R. W., Moon R. T. RT Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway RL Nature 422:905-9 (2003). RN [52]; RE0037559. RX PUBMED: 15087387. RA Hoang B. H., Kubo T., Healey J. H., Yang R., Nathan S. S., Kolb E. A., Mazza B., Meyers P. A., Gorlick R. RT Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway RL Cancer Res. 64:2734-9 (2004). RN [53]; RE0037560. RX PUBMED: 12874278. RA Kanamori M., Sandy P., Marzinotto S., Benetti R., Kai C., Hayashizaki Y., Schneider C., Suzuki H. RT The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells RL J. Biol. Chem. 278:38758-64 (2003). RN [54]; RE0037561. RX PUBMED: 11751639. RA Tutter A. V., Fryer C. J., Jones K. A. RT Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro RL Genes Dev. 15:3342-54 (2001). RN [55]; RE0037576. RX PUBMED: 15077166. RA Tong X., O'kelly J., Xie D., Mori A., Lemp N., McKenna R., Miller C. W., Koeffler H. P. RT Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway RL Oncogene 23:4847-55 (2004). RN [56]; RE0037579. RX PUBMED: 15116100. RA Pradeep A., Sharma C., Sathyanarayana P., Albanese C., Fleming J. V., Wang T. C., Wolfe M. M., Baker K. M., Pestell R. G., Rana B. RT Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells RL Oncogene 23:3689-99 (2004). RN [57]; RE0037605. RX PUBMED: 12651860. RA Ghiselli G., Coffee N., Munnery C. E., Koratkar R., Siracusa L. D. RT The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway RL J. Biol. Chem. 278:20259-67 (2003). RN [58]; RE0037675. RX PUBMED: 11939410. RA Miwa N., Furuse M., Tsukita S., Niikawa N., Nakamura Y., Furukawa Y. RT Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers RL Oncol. Res. 12:469-76 (2001). RN [59]; RE0037730. RX PUBMED: 12734196. RA Katafiasz B. J., Nieman M. T., Wheelock M. J., Johnson K. R. RT Characterization of cadherin-24, a novel alternatively spliced type II cadherin RL J. Biol. Chem. 278:27513-9 (2003). RN [60]; RE0037822. RX PUBMED: 8638125. RA Matsumine A., Ogai A., Senda T., Okumura N., Satoh K., Baeg G. H., Kawahara T., Kobayashi S., Okada M., Toyoshima K., Akiyama T. RT Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein RL Science 272:1020-3 (1996). RN [61]; RE0037843. RX PUBMED: 11445844. RA Saitoh T., Katoh M. RT FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer RL Int. J. Oncol. 19:311-5 (2001). RN [62]; RE0037884. RX PUBMED: 11483515. RA Li X., Yost H. J., Virshup D. M., Seeling J. M. RT Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus RL EMBO J. 20:4122-31 (2001). RN [63]; RE0037951. RX PUBMED: 12954618. RA Zoltan-Jones A., Huang L., Ghatak S., Toole B. P. RT Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells RL J. Biol. Chem. 278:45801-10 (2003). RN [64]; RE0037955. RX PUBMED: 12761500. RA Wang W. S., Chen P. M., Hsiao H. L., Ju S. Y., Su Y. RT Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells RL Oncogene 22:3297-306 (2003). RN [65]; RE0037992. RX PUBMED: 11741304. RA Katoh M., Kirikoshi H., Terasaki H., Shiokawa K. RT WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway RL Biochem. Biophys. Res. Commun. 289:1093-8 (2001). RN [66]; RE0037998. RX PUBMED: 12393001. RA van Veen T. A., van Rijen H. V., Wiegerinck R. F., Opthof T., Colbert M. C., Clement S., de Bakker J. M., Jongsma H. J. RT Remodeling of gap junctions in mouse hearts hypertrophied by forced retinoic acid signaling RL J. Mol. Cell. Cardiol. 34:1411-23 (2002). RN [67]; RE0037999. RX PUBMED: 12588987. RA Song L. N., Herrell R., Byers S., Shah S., Wilson E. M., Gelmann E. P. RT Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription RL Mol. Cell. Biol. 23:1674-87 (2003). RN [68]; RE0038021. RX PUBMED: 14559775. RA Ertekin-Taner N., Ronald J., Asahara H., Younkin L., Hella M., Jain S., Gnida E., Younkin S., Fadale D., Ohyagi Y., Singleton A., Scanlin L., de Andrade M., Petersen R., Graff-Radford N., Hutton M., Younkin S. RT Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees RL Hum. Mol. Genet. 12:3133-43 (2003). RN [69]; RE0038121. RX PUBMED: 12354293. RA Zhang D., Zhang L., Lou D. W., Nakabeppu Y., Zhang J., Xu M. RT The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression RL J. Neurochem 82:1453-64 (2002). RN [70]; RE0038122. RX PUBMED: 12447692. RA Cadoret A., Ovejero C., Terris B., Souil E., Levy L., Lamers W. H., Kitajewski J., Kahn A., Perret C. RT New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism RL Oncogene 21:8293-301 (2002). RN [71]; RE0038123. RX PUBMED: 10797259. RA Hanada N., Makino K., Koga H., Morisaki T., Kuwahara H., Masuko N., Tabira Y., Hiraoka T., Kitamura N., Kikuchi A., Saya H. RT NE-dlg, a mammalian homolog of Drosophila dlg tumor suppressor, induces growth suppression and impairment of cell adhesion: possible involvement of down-regulation of beta-catenin by NE-dlg expression RL Int. J. Cancer 86:480-8 (2000). RN [72]; RE0038124. RX PUBMED: 15023540. RA Nguyen V. T., Chernyavsky A. I., Arredondo J., Bercovich D., Orr-Urtreger A., Vetter D. E., Wess J., Beaudet A. L., Kitajima Y., Grando S. A. RT Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes RL Exp. Cell Res. 294:534-49 (2004). RN [73]; RE0038127. RX PUBMED: 12408869. RA Batlle E., Henderson J. T., Beghtel H., van den Born M. M., Sancho E., Huls G., Meeldijk J., Robertson J., van de Wetering M., Pawson T., Clevers H. RT Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB RL Cell 111:251-63 (2002). RN [74]; RE0038128. RX PUBMED: 11313461. RA Vallentin A., Lo T. C., Joubert D. RT A single point mutation in the V3 region affects protein kinase Calpha targeting and accumulation at cell-cell contacts RL Mol. Cell. Biol. 21:3351-63 (2001). RN [75]; RE0038202. RX PUBMED: 9205085. RA Paul R., Ewing C. M., Robinson J. C., Marshall F. F., Johnson K. R., Wheelock M. J., Isaacs W. B. RT Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma RL Cancer Res. 57:2741-8 (1997). RN [76]; RE0038209. RX PUBMED: 14559787. RA Shimokawa T., Furukawa Y., Sakai M., Li M., Miwa N., Lin Y. M., Nakamura Y. RT Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex RL Cancer Res. 63:6116-20 (2003). RN [77]; RE0038252. RX PUBMED: 14563838. RA Diks S. H., Hardwick J. C., Diab R. M., van Santen M. M., Versteeg H. H., van Deventer S. J., Richel D. J., Peppelenbosch M. P. RT Activation of the canonical beta-catenin pathway by histamine RL J. Biol. Chem. 278:52491-6 (2003). RN [78]; RE0038335. RX PUBMED: 14567991. RA Svastova E., Zilka N., Zat'ovicova M., Gibadulinova A., Ciampor F., Pastorek J., Pastorekova S. RT Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin RL Exp. Cell Res. 290:332-45 (2003). 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RA Kitada T., Miyoshi E., Noda K., Higashiyama S., Ihara H., Matsuura N., Hayashi N., Kawata S., Matsuzawa Y., Taniguchi N. RT The Addition of Bisecting N-Acetylglucosamine Residues to E-cadherin Down-regulates the Tyrosine Phosphorylation of beta -Catenin RL J. Biol. Chem. 276:475-480 (2001). RN [83]; RE0038575. RX PUBMED: 12808048. RA Wadham C., Gamble J. R., Vadas M. A., Khew-Goodall Y. RT The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin RL Mol. Biol. Cell 14:2520-9 (2003). RN [84]; RE0038576. RX PUBMED: 9788868. RA Spiryda L. B., Colman D. R. RT Suppression of tumorigenicity in an aggressive cervical carcinoma induced by protein zero, a nervous system IgCAM RL J. Cell Sci. 111:3253-60 (1998). RN [85]; RE0038577. RX PUBMED: 11749037. RA Menichella D. M., Arroyo E. J., Awatramani R., Xu T., Baron P., Vallat J. M., Balsamo J., Lilien J., Scarlato G., Kamholz J., Scherer S. S., Shy M. E. RT Protein zero is necessary for E-cadherin-mediated adherens junction formation in Schwann cells RL Mol. Cell. Neurosci. 18:606-18 (2001). RN [86]; RE0038578. RX PUBMED: 11790773. RA Chen X., Bonne S., Hatzfeld M., van Roy F., Green K. J. RT Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling RL J. Biol. Chem. 277:10512-22 (2002). RN [87]; RE0038689. RX PUBMED: 11983685. RA Koh S. S., Li H., Lee Y. H., Widelitz R. B., Chuong C. M., Stallcup M. R. RT Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators RL J. Biol. Chem. 277:26031-5 (2002). RN [88]; RE0038746. RX PUBMED: 14623818. RA Morkel M., Huelsken J., Wakamiya M., Ding J., van de Wetering M., Clevers H., Taketo M. M., Behringer R. R., Shen M. M., Birchmeier W. RT Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation RL Development 130:6283-94 (2003). RN [89]; RE0038832. RX PUBMED: 14612447. RA Townsley F. M., Thompson B., Bienz M. RT Pygopus residues required for its binding to Legless are critical for transcription and development RL J. Biol. Chem. 279:5177-83 (2004). RN [90]; RE0038972. RX PUBMED: 11576997. RA Yano T., Hernandez-Blazquez F. J., Omori Y., Yamasaki H. RT Reduction of malignant phenotype of HEPG2 cell is associated with the expression of connexin 26 but not connexin 32 RL Carcinogenesis 22:1593-600 (2001). RN [91]; RE0038974. RX PUBMED: 9547311. RA Norvell S. M., Green K. J. RT Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells RL J. Cell Sci. 111:1305-18 (1998). RN [92]; RE0038976. RX PUBMED: 11532957. RA Barker N., Hurlstone A., Musisi H., Miles A., Bienz M., Clevers H. RT The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation RL EMBO J. 20:4935-43 (2001). RN [93]; RE0039023. RX PUBMED: 9168809. RA Kuch C., Winnekendonk D., Butz S., Unvericht U., Kemler R., Starzinski-Powitz A. RT M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells RL Exp. Cell Res. 232:331-8 (1997). RN [94]; RE0039024. RX PUBMED: 11976333. RA Meigs T. E., Fedor-Chaiken M., Kaplan D. D., Brackenbury R., Casey P. J. RT Galpha 12 and galpha 13 negatively regulate the adhesive functions of cadherin RL J. Biol. Chem. 277:24594-600 (2002). RN [95]; RE0039084. RX PUBMED: 15084463. RA Lo Celso C., Prowse D. M., Watt F. M. RT Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours RL Development 131:1787-99 (2004). RN [96]; RE0039085. RX PUBMED: 12917489. RA Niemann C., Unden A. B., Lyle S., Zouboulis ChC, Toftgard R., Watt F. M. RT Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis RL Proc. Natl. Acad. Sci. USA 100:11873-11880 (2003). RN [97]; RE0039090. RX PUBMED: 14506735. RA Alami J., Williams B. R., Yeger H. RT Derivation and characterization of a Wilms' tumour cell line, WiT 49 RL Int. J. Cancer 107:365-74 (2003). RN [98]; RE0039093. RX PUBMED: 11267998. RA Wang H., Chakrabarty S. RT Requirement of protein kinase Calpha, extracellular matrix remodeling, and cell-matrix interaction for transforming growth factorbeta-regulated expression of E-cadherin and catenins RL J. Cell. Physiol. 187:188-95 (2001). RN [99]; RE0039688. RX PUBMED: 10029089. RA Pishvaian M. J., Feltes C. M., Thompson P., Bussemakers M. J., Schalken J. A., Byers S. W. RT Cadherin-11 is expressed in invasive breast cancer cell lines RL Cancer Res. 59:947-52 (1999). RN [100]; RE0039845. RX PUBMED: 12800191. RA Patel I. S., Madan P., Getsios S., Bertrand M. A., MacCalman C. D. RT Cadherin switching in ovarian cancer progression RL Int. J. Cancer 106:172-7 (2003). RN [101]; RE0039950. RX PUBMED: 12239602. RA Kirikoshi H., Katoh M. RT Expression and regulation of WNT10B in human cancer: up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid RL Int. J. Mol. Med. 10:507-11 (2002). RN [102]; RE0039952. RX PUBMED: 10797287. RA Sasaki C. Y., Lin Hc, Passaniti A. RT Expression of E-cadherin reduces bcl-2 expression and increases sensitivity to etoposide-induced apoptosis RL Int. J. Cancer 86:660-6 (2000). RN [103]; RE0040038. RX PUBMED: 12535644. RA Bain G., Muller T., Wang X., Papkoff J. RT Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction RL Biochem. Biophys. Res. Commun. 301:84-91 (2003). RN [104]; RE0040228. RX PUBMED: 12501215. RA Yan H. X., He Y. Q., Dong H., Zhang P., Zeng J. Z., Cao H. F., Wu M. C., Wang H. Y. RT Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin RL Biochemistry 41:15854-60 (2002). RN [105]; RE0040237. RX PUBMED: 15198985. RA Aubin J., Davy A., Soriano P. RT In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis RL Genes Dev. 18:1482-94 (2004). RN [106]; RE0040246. RX PUBMED: 10893270. RA Toyofuku T., Hong Z., Kuzuya T., Tada M., Hori M. RT Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex RL J. Cell Biol. 150:225-42 (2000). RN [107]; RE0040264. RX PUBMED: 14639622. RA Hlubek F., Spaderna S., Jung A., Kirchner T., Brabletz T. RT Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas RL Int. J. Cancer 108:321-6 (2004). RN [108]; RE0040268. RX PUBMED: 15026334. RA Xie D., Yin D., Tong X., O'kelly J., Mori A., Miller C., Black K., Gui D., Said J. W., Koeffler H. P. RT Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways RL Cancer Res. 64:1987-96 (2004). RN [109]; RE0040278. RX PUBMED: 12063257. RA Liu T., Lee Y. N., Malbon C. C., Wang H. Y. RT Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid RL J. Biol. Chem. 277:30887-91 (2002). RN [110]; RE0040281. RX PUBMED: 11387477. RA Liu T., DeCostanzo A. J., Liu X., Wang Hy, Hallagan S., Moon R. T., Malbon C. C. RT G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway RL Science 292:1718-22 (2001). RN [111]; RE0040355. RX PUBMED: 10958684. RA Billin A. N., Thirlwell H., Ayer D. E. RT Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator RL Mol. Cell. Biol. 20:6882-90 (2000). RN [112]; RE0040358. RX PUBMED: 12615962. RA Hollande F., Lee D. J., Choquet A., Roche S., Baldwin G. S. RT Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells RL J. Cell Sci. 116:1187-97 (2003). RN [113]; RE0040380. RX PUBMED: 11369768. RA Fadel M. P., Szewczenko-Pawlikowski M., Leclerc P., Dziak E., Symonds J. M., Blaschuk O., Michalak M., Opas M. RT Calreticulin affects beta-catenin-associated pathways RL J. Biol. Chem. 276:27083-9 (2001). RN [114]; RE0040383. RX PUBMED: 11973335. RA Wolf D., Rodova M., Miska E. A., Calvet J. P., Kouzarides T. RT Acetylation of beta-catenin by CREB-binding protein (CBP) RL J. Biol. Chem. 277:25562-7 (2002). RN [115]; RE0040428. RX PUBMED: 11278257. RA Fujino H., Regan J. W. RT FP prostanoid receptor activation of a T-cell factor/beta -catenin signaling pathway RL J. Biol. Chem. 276:12489-92 (2001). RN [116]; RE0040430. RX PUBMED: 12048202. RA Rodova M., Islam M. R., Maser R. L., Calvet J. P. RT The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway RL J. Biol. Chem. 277:29577-83 (2002). RN [117]; RE0040432. RX PUBMED: 14718571. RA Roitbak T., Ward C. J., Harris P. C., Bacallao R., Ness S. A., Wandinger-Ness A. RT A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells RL Mol. Biol. Cell 15:1334-46 (2004). RN [118]; RE0040433. RX PUBMED: 10322638. RA van Adelsberg J. RT Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney RL Dev. Genet. 24:299-308 (1999). RN [119]; RE0040549. RX PUBMED: 12954078. RA Moldes M., Zuo Y., Morrison R. F., Silva D., Park B. H., Liu J., Farmer S. R. RT Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis RL Biochem. J. 376:607-13 (2003). RN [120]; RE0040552. RX PUBMED: 12865297. RA Pinto D., Gregorieff A., Begthel H., Clevers H. RT Canonical Wnt signals are essential for homeostasis of the intestinal epithelium RL Genes Dev. 17:1709-13 (2003). RN [121]; RE0040553. RX PUBMED: 14586135. RA Kundu A. K., Nagaoka M., Chowdhury E. H., Hirose S., Sasagawa T., Akaike T. RT IGF-1 induces growth, survival and morphological change of primary hepatocytes on a galactose-bared polymer through both MAPK and beta-catenin pathways RL Cell Struct. Funct. 28:255-63 (2003). RN [122]; RE0040563. RX PUBMED: 10906119. RA Miyagishi M., Fujii R., Hatta M., Yoshida E., Araya N., Nagafuchi A., Ishihara S., Nakajima T., Fukamizu A. RT Regulation of lef-mediated transcription and p53-dependent pathway by associating beta -catenin with CBP/p300 RL J. Biol. Chem. 275:35170-5 (2000). RN [123]; RE0042338. RX PUBMED: 11809808. RA Jho E. H., Zhang T., Domon C., Joo C. K., Freund J. N., Costantini F. RT Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway RL Mol. Cell. Biol. 22:1172-83 (2002). RN [124]; RE0042766. RX PUBMED: 11423974. RA Landesman-Bollag E., Romieu-Mourez R., Song D. H., Sonenshein G. E., Cardiff R. D., Seldin D. C. RT Protein kinase CK2 in mammary gland tumorigenesis RL Oncogene 20:3247-57 (2001). RN [125]; RE0045017. RX PUBMED: 12727850. RA Kajiyama H., Kikkawa F., Khin E., Shibata K., Ino K., Mizutani S. RT Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells RL Cancer Res. 63:2278-83 (2003). RN [126]; RE0045311. RX PUBMED: 15240817. RA McCormick J. A., Feng Y., Dawson K., Behne M. J., Yu B., Wang J., Wyatt A. W., Henke G., Grahammer F., Mauro T. M., Lang F., Pearce D. RT Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development RL Mol. Biol. Cell 15:4278-88 (2004). RN [127]; RE0045344. RX PUBMED: 15374939. RA Shimura T., Takenaka Y., Tsutsumi S., Hogan V., Kikuchi A., Raz A. RT Galectin-3, a novel binding partner of beta-catenin RL Cancer Res. 64:6363-7 (2004). RN [128]; RE0045345. RX PUBMED: 15367663. RA Naito M., Katayama R., Ishioka T., Suga A., Takubo K., Nanjo M., Hashimoto C., Taira M., Takada S., Takada R., Kitagawa M., Matsuzawa S., Reed J. C., Tsuruo T. RT Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling RL Mol. Cell. Biol. 24:8418-27 (2004). RN [129]; RE0045353. RX PUBMED: 11256997. RA Goichberg P., Shtutman M., Ben-Ze'ev A., Geiger B. RT Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction RL J. Cell Sci. 114:1309-19 (2001). RN [130]; RE0045361. RX PUBMED: 15308623. RA Liu J., Farmer S. R. RT Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes RL J. Biol. Chem. 279:45020-7 (2004). RN [131]; RE0046214. RX PUBMED: 14960280. RA Nastasi T., Bongiovanni A., Campos Y., Mann L., Toy J. N., Bostrom J., Rottier R., Hahn C., Conaway J. W., Harris A. J., d'Azzo A. RT Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis RL Dev. Cell 6:269-82 (2004). RN [132]; RE0046743. RX PUBMED: 12221118. RA Nurnberger J., Bacallao R. L., Phillips C. L. RT Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells RL Mol. Biol. Cell 13:3096-106 (2002). RN [133]; RE0046966. RX PUBMED: 15592430. RA Chamorro M. N., Schwartz D. R., Vonica A., Brivanlou A. H., Cho K. R., Varmus H. E. RT FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development RL EMBO J. 24:73-84 (2005). RN [134]; RE0050491. RX PUBMED: 16569639. RA Tzeng S. L., Cheng Y. W., Li C. H., Lin Y. S., Hsu H. C., Kang J. J. RT Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. RL J. Biol. Chem. 281:15405-15411 (2006). RN [135]; RE0053569. RX PUBMED: 16543149. RA Shah S., Islam M. N., Dakshanamurthy S., Rizvi I., Rao M., Herrell R., Zinser G., Valrance M., Aranda A., Moras D., Norman A., Welsh J., Byers S. W. RT The molecular basis of vitamin D receptor and beta-catenin crossregulation. RL Mol. Cell 21:799-809 (2006). RN [136]; RE0054586. RX PUBMED: 17620337. RA Kizhatil K., Davis J. Q., Davis L., Hoffman J., Hogan B. L., Bennett V. RT Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. RL J. Biol. Chem. 282:26552-26561 (2007). RN [137]; RE0062741. RX PUBMED: 18086858. RA Bahmanyar S., Kaplan D. D., Deluca J. G., Giddings TH J. r., O'Toole E. T., Winey M., Salmon E. D., Casey P. J., Nelson W. J., Barth A. I. RT beta-Catenin is a Nek2 substrate involved in centrosome separation. RL Genes Dev. 22:91-105 (2008). RN [138]; RE0066261. RX PUBMED: 18936100. RA Gao X., Wen J., Zhang L., Li X., Ning Y., Meng A., Chen Y. G. RT Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. RL J. Biol. Chem. 283:35679-35688 (2008). RN [139]; RE0066628. RX PUBMED: 11500377. RA Sampson E. M., Haque Z. K., Ku M. C., Tevosian S. G., Albanese C., Pestell R. G., Paulson K. E., Yee A. S. RT Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. RL EMBO J. 20:4500-4511 (2001). RN [140]; RE0068708. RX PUBMED: 20307497. RA Kim E. A., Kim J. E., Sung K. S., Choi D. W., Lee B. J., Choi C. Y. RT Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. RL Biochem. Biophys. Res. Commun. 394:966-971 (2010). RN [141]; RE0069008. RX PUBMED: 15158448. RA Sato A., Kishida S., Tanaka T., Kikuchi A., Kodama T., Asashima M., Nishinakamura R. RT Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin. RL Biochem. Biophys. Res. Commun. 319:103-113 (2004). RN [142]; RE0070036. RX PUBMED: 21118991. RA Hay-Koren A., Caspi M., Zilberberg A., Rosin-Arbesfeld R. RT The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. RL Mol. Biol. Cell 22:399-411 (2011). RN [143]; RE0071593. RX PUBMED: 11716761. RA Woodfield R. J., Hodgkin M. N., Akhtar N., Morse M. A., Fuller K. J., Saqib K., Thompson N. T., Wakelam M. J. RT The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex. RL Biochem. 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