TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T09551 XX ID T09551 XX DT 10.03.2005 (created); nvo. DT 07.02.2016 (updated); vis. CO Copyright (C), QIAGEN. XX FA LEF-1 XX SY Lymphoid enhancer factor 1. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX FF LEF-1 can repress the AML3 T09552-mediated transactivation of OC2 G001163 (possibly by binding to RHD DNA-binding domain of AML3), and in this repression HMG and beta-catenin-interacting domains of LEF-1 plays a crucial role. [15]; XX IN T09959 AML2; Mammalia. IN T09552 AML3; Mammalia. IN T02984 beta-catenin; mouse, Mus musculus. IN T14513 beta-catenin; Mammalia. IN T09446 c-Jun; Mammalia. IN T17679 c-Myb; Mammalia. IN T23083 Cdx-1; Mammalia. IN T01308 CREBPA; human, Homo sapiens. IN T18317 Dlx-2; Mammalia. IN T21852 HDAC1; Mammalia. IN T30592 Msx-1; Mammalia. IN T10542 p300; mouse, Mus musculus. IN T10303 Pax-5; Mammalia. IN T28503 pitx2a; Mammalia. IN T24830 Smad2; Mammalia. IN T09538 Smad3; Mammalia. IN T13998 Smad4; Mammalia. IN T16693 TCF-3; Mammalia. XX MX M00978 V$LEF1TCF1_Q4. MX M00805 V$LEF1_Q2. MX M01022 V$LEF1_Q2_01. MX M07046 V$LEF1_Q3. MX M07605 V$LEF1_Q4. MX M02019 V$LEF1_Q5. MX M03794 V$LEF1_Q5_01. MX M08902 V$TCF7RELATED_Q4. XX BS R31106. BS R33556. BS R60926. BS R33002. BS R71738. BS R71739. BS R30932. BS R30942. BS R30943. BS R30947. BS R30948. BS R30795. BS R25773. BS R19738. BS R31108. BS R38304. BS R38306. BS R73753. BS R41807. BS R41809. BS R70517. BS R70518. BS R70519. BS R70521. BS R70524. BS R70527. BS R70528. BS R70529. BS R70530. BS R41811. BS R64480. BS R29459. BS R41815. BS R64323. BS R68211. BS R68213. BS R33858. BS R58904. BS R58905. BS R58906. BS R41818. BS R66365. BS R67193. BS R25933. BS R28447. BS R27122. BS R69025. BS R69028. BS R69031. BS R69037. BS R69040. BS R69043. BS R69046. BS R69051. BS R69054. BS R69057. BS R61738. BS R61745. BS R61746. BS R61749. BS R61752. BS R61753. BS R61754. BS R61755. BS R41819. XX DR TRANSPATH: MO000046464. DR TRANSCOMPEL: C00194. DR TRANSCOMPEL: C00547. XX RN [1]; RE0006054. RX PUBMED: 9106660. RA Mayall T. P., Sheridan P. L., Montminy M. R., Jones K. A. RT Distinct roles for P-CREB and LEF-1 in TCRalpha enhancer assembly and activation on chromatin templates in vitro RL Genes Dev. 11:887-899 (1997). RN [2]; RE0013411. RX PUBMED: 9751710. RA Levanon D., Goldstein R. E., Bernstein Y., Tang H., Goldenberg D., Stifani S., Paroush Z., Groner Y. RT Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors RL Proc. Natl. Acad. Sci. USA 95:11590-11595 (1998). RN [3]; RE0014054. RX PUBMED: 8631802. RA Prieve M. G., Guttridge K. L., Munguia J. E., Waterman M. L. RT The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins RL J. Biol. Chem. 271:7654-7658 (1996). RN [4]; RE0014183. RX PUBMED: 9539744. RA Novak A., Hsu S. C., Leung-Hagesteijn C., Radeva G., Papkoff J., Montesano R., Roskelley C., Grosschedl R., Dedhar S. RT Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways RL Am. J. Pathol. 95:4374-4379 (1998). RN [5]; RE0014255. RX PUBMED: 10223208. RA Mei J. M., Hord N. G., Winterstein D. F., Donald S. P., Phang J. M. RT Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc RL Carcinogenesis 20:737-740 (1999). RN [6]; RE0018686. RX PUBMED: 10825188. RA Zhurinsky J., Shtutman M., Ben-Ze'ev A. RT Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin RL Mol. Cell. Biol. 20:4238-4252 (2000). RN [7]; RE0023725. RX PUBMED: 12556497. RA Ishitani T., Ninomiya-Tsuji J., Matsumoto K. RT Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. RL Mol. Cell. Biol. 23:1379-1389 (2003). RN [8]; RE0024462. RX PUBMED: 11742073. RA Chen W., Hu L. A., Semenov M. V., Yanagawa S., Kikuchi A., Lefkowitz R. J., Miller W. E. RT beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. RL Proc. Natl. Acad. Sci. USA 98:14889-14894 (2001). RN [9]; RE0025179. RX PUBMED: 11696550. RA Boras K., Hamel P. A. RT Alx4 binding to LEF-1 regulates N-CAM promoter activity. RL J. Biol. Chem. 277:1120-1127 (2002). RN [10]; RE0025198. RX PUBMED: 11731474. RA Sachdev S., Bruhn L., Sieber H., Pichler A., Melchior F., Grosschedl R. RT PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies RL Genes Dev. 15:3088-3103 (2001). RN [11]; RE0027408. RX PUBMED: 11203701. RA Laurikkala J., Mikkola M., Mustonen T., Aberg T., Koppinen P., Pispa J., Nieminen P., Galceran J., Grosschedl R., Thesleff I. RT TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. RL Dev. Biol. 229:443-55 (2001). RN [12]; RE0030303. RX PUBMED: 12748295. RA Grueneberg D. A., Pablo L., Hu K. Q., August P., Weng Z., Papkoff J. RT A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway. RL Mol. Cell. Biol. 23:3936-50 (2003). RN [13]; RE0030476. RX PUBMED: 12192039. RA Kusano S., Raab-Traub N. RT I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. RL Mol. Cell. Biol. 22:6393-405 (2002). RN [14]; RE0031565. RX PUBMED: 14638683. RA Li H., Kim J. H., Koh S. S., Stallcup M. R. RT Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. RL J. Biol. Chem. 279:4212-20 (2004). RN [15]; RE0031614. RX PUBMED: 12551949. RA Kahler R. A., Westendorf J. J. RT Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. RL J. Biol. Chem. 278:11937-44 (2003). RN [16]; RE0031857. RX PUBMED: 12502739. RA Kratochwil K., Galceran J., Tontsch S., Roth W., Grosschedl R. RT FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. RL Genes Dev. 16:3173-85 (2002). RN [17]; RE0032129. RX PUBMED: 14691138. RA Nawshad A., Hay E. D. RT TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. RL J. Cell Biol. 163:1291-301 (2003). RN [18]; RE0032226. RX PUBMED: 15013427. RA Shindo M., Chaudhary P. M. RT The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. RL Biochem. Biophys. Res. Commun. 315:73-8 (2004). RN [19]; RE0033187. RX PUBMED: 15143193. RA Beland M., Pilon N., Houle M., Oh K., Sylvestre J. R., Prinos P., Lohnes D. RT Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. RL Mol. Cell. Biol. 24:5028-38 (2004). RN [20]; RE0040220. RX PUBMED: 11835406. RA Fischer L., Boland G., Tuan R. S. RT Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis RL J. Cell. Biochem. 84:816-31 (2002). RN [21]; RE0040268. RX PUBMED: 15026334. RA Xie D., Yin D., Tong X., O'kelly J., Mori A., Miller C., Black K., Gui D., Said J. W., Koeffler H. P. RT Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways RL Cancer Res. 64:1987-96 (2004). RN [22]; RE0040355. RX PUBMED: 10958684. RA Billin A. N., Thirlwell H., Ayer D. E. RT Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator RL Mol. Cell. Biol. 20:6882-90 (2000). RN [23]; RE0040638. RX PUBMED: 15169916. RA Wong K. A., Kim R., Christofk H., Gao J., Lawson G., Wu H. RT Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life RL Mol. Cell. Biol. 24:5577-86 (2004). RN [24]; RE0040984. RX PUBMED: 9545244. RA Nutt S. L., Morrison A. M., Dorfler P., Rolink A., Busslinger M. RT Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments RL EMBO J. 17:2319-33 (1998). RN [25]; RE0045311. RX PUBMED: 15240817. RA McCormick J. A., Feng Y., Dawson K., Behne M. J., Yu B., Wang J., Wyatt A. W., Henke G., Grahammer F., Mauro T. M., Lang F., Pearce D. RT Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development RL Mol. Biol. Cell 15:4278-88 (2004). RN [26]; RE0066261. RX PUBMED: 18936100. RA Gao X., Wen J., Zhang L., Li X., Ning Y., Meng A., Chen Y. G. RT Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. RL J. Biol. Chem. 283:35679-35688 (2008). RN [27]; RE0066628. RX PUBMED: 11500377. RA Sampson E. M., Haque Z. K., Ku M. C., Tevosian S. G., Albanese C., Pestell R. G., Paulson K. E., Yee A. S. RT Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. RL EMBO J. 20:4500-4511 (2001). RN [28]; RE0067979. RX PUBMED: 17068080. RA Diamond E., Amen M., Hu Q., Espinoza H. M., Amendt B. A. RT Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2. RL Nucleic Acids Res. 34:5951-5965 (2006). RN [29]; RE0070604. RX PUBMED: 20363964. RA Chen Q. Y., Zhang T., Pincus S. H., Wu S., Ricks D., Liu D., Sun Z., Maclaren N., Lan M. S. RT Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements. RL J. Immunol. 184:5047-5054 (2010). XX //