AC T09538
XX
ID T09538
XX
DT 10.03.2005 (created); nvo.
DT 22.09.2015 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA Smad3
XX
SY JV15-2; MAD, mothers against decapentaplegic homolog 3 (Drosophila); Mad3; MADH3; Mothers against DPP homolog 3; SMAD3.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09248 AML2-isoform1; human, Homo sapiens.
IN T09552 AML3; Mammalia.
IN T15601 AR; Mammalia.
IN T23092 BF-1; Mammalia.
IN T08887 brca1-isoform1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T02211 BTEB2; human, Homo sapiens.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T14435 c-Myc; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T15118 CBP; Mammalia.
IN T14206 ctcf; Mammalia.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T08515 ER-beta; human, Homo sapiens.
IN T16696 FoxH1; Mammalia.
IN T11171 foxl2; human, Homo sapiens.
IN T09104 FOXO1A; mouse, Mus musculus.
IN T08197 FOXO3a; human, Homo sapiens.
IN T03403 foxo4; human, Homo sapiens.
IN T13822 GATA-3; Mammalia.
IN T08629 GATA-4; Mammalia.
IN T30499 gli3; Mammalia.
IN T10446 GR; Mammalia.
IN T24827 Gsc; mouse, Mus musculus.
IN T05490 Hic-5; human, Homo sapiens.
IN T10516 HIF-1alpha; Mammalia.
IN T08626 HNF-3alpha; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T18466 IRF-7; Mammalia.
IN T10510 JunB; Mammalia.
IN T09447 JunD; Mammalia.
IN T09551 LEF-1; Mammalia.
IN T13873 MITF; Mammalia.
IN T32367 MRG-1-isoform1; mouse, Mus musculus.
IN T17897 myocardin; Mammalia.
IN T10027 MyoD; Mammalia.
IN T19713 NF-1A; Mammalia.
IN T19712 NF-1B; Mammalia.
IN T30989 NF-1C; Mammalia.
IN T15389 NF-IX; Mammalia.
IN T17293 NF-YC; Mammalia.
IN T31925 Oligo1; Mammalia.
IN T23091 p300; Mammalia.
IN T09500 p53; Mammalia.
IN T06137 p73beta; human, Homo sapiens.
IN T13888 pax6; Mammalia.
IN T28503 pitx2a; Mammalia.
IN T32202 Pitx2C; Mammalia.
IN T09963 PPARgamma; Mammalia.
IN T09984 Prep-1; Mammalia.
IN T34370 RN3; human, Homo sapiens.
IN T09086 Smad2; mouse, Mus musculus.
IN T24830 Smad2; Mammalia.
IN T05067 Smad4; mouse, Mus musculus.
IN T13998 Smad4; Mammalia.
IN T09153 SnoN; human, Homo sapiens.
IN T01853 Sox-9; human, Homo sapiens.
IN T05485 Sox-9; rat, Rattus norvegicus.
IN T08326 Sp1; Mammalia.
IN T01560 SREBP-2; human, Homo sapiens.
IN T16049 SREBP-2; Mammalia.
IN T16666 SREBP-2; mink, Mustela vison.
IN T14063 SRF; Mammalia.
IN T00997 SRY; human, Homo sapiens.
IN T14458 STAT3; Mammalia.
IN T09192 TFEA; mouse, Mus musculus.
IN T17416 tfeb; Mammalia.
IN T09151 TGIF2-isoform1; human, Homo sapiens.
IN T04076 TGIF; human, Homo sapiens.
IN T00857 TTF-1; human, Homo sapiens.
IN T16163 YB-1; Mammalia.
IN T14846 ZEB; Mammalia.
IN T22793 znf8; mouse, Mus musculus.
XX
MX M00701 V$SMAD3_Q6.
MX M01888 V$SMAD3_Q6_01.
MX M07429 V$SMAD3_Q6_02.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R62324.
BS R10092.
BS R32453.
BS R61106.
BS R23179.
BS R35939.
BS R36234.
BS R33570.
BS R29095.
BS R29096.
BS R29097.
BS R73003.
BS R36817.
BS R59127.
BS R59128.
BS R38218.
BS R29688.
BS R57121.
BS R66539.
BS R37518.
BS R37520.
BS R10079.
BS R36862.
BS R71597.
BS R26158.
BS R26160.
BS R26161.
BS R73381.
BS R37810.
BS R37811.
BS R37812.
BS R71637.
BS R36216.
BS R36221.
BS R30936.
BS R19731.
BS R10063.
BS R10066.
BS R30958.
XX
DR TRANSPATH: MO000046747.
DR TRANSCOMPEL: C00194.
DR TRANSCOMPEL: C00242.
DR TRANSCOMPEL: C00548.
XX
RN [1]; RE0016069.
RX PUBMED: 10871633.
RA Dennler S., Prunier C., Ferrand N., Gauthier J. M., Atfi A.
RT c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity.
RL J. Biol. Chem. 275:28858-28865 (2000).
RN [2]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
RN [3]; RE0016410.
RX PUBMED: 10485843.
RA Luo K., Stroschein S. L., Wang W., Chen D., Martens E., Zhou S., Zhou Q.
RT The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.
RL Genes Dev. 13:2196-2206 (1999).
RN [4]; RE0018856.
RX PUBMED: 11118211.
RA Liu X., Elia A. E. H., Law S. F., Golemis E. A., Farley J., Wang T.
RT A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1
RL EMBO J. 19:6759-6769 (2000).
RN [5]; RE0020655.
RX PUBMED: 11294908.
RA Kurisaki A., Kose S., Yoneda Y., Heldin C.-H., Moustakas A.
RT Transforming Growth Factor-beta Induces Nuclear Import of Smad3 in an Importin-beta1 and Ran-dependent Manner
RL Mol. Biol. Cell 12:1079-1091 (2001).
RN [6]; RE0022199.
RX PUBMED: 11486006.
RA Sanchez-Elsner T., Botella L. M., Velasco B., Corbi A., Attisano L., Bernabeu C.
RT Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.
RL J. Biol. Chem. 276:38527-38535 (2001).
RN [7]; RE0022446.
RX PUBMED: 12161428.
RA Li C., Zhu N. L., Tan R. C., Ballard P. L., Derynck R., Minoo P.
RT Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
RL J. Biol. Chem. 277:38399-38408 (2002).
RN [8]; RE0023200.
RX PUBMED: 12631740.
RA Chou W. C., Prokova V., Shiraishi K., Valcourt U., Moustakas A., Hadzopoulou-Cladaras M., Zannis V. I., Kardassis D.
RT Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-beta-regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4.
RL Mol. Biol. Cell 14:1279-1294 (2003).
RN [9]; RE0023714.
RX PUBMED: 11387330.
RA Rodriguez C., Huang L. J., Son J. K., McKee A., Xiao Z., Lodish H. F.
RT Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:30224-30230 (2001).
RN [10]; RE0023952.
RX PUBMED: 10903323.
RA Verrecchia F., Pessah M., Atfi A., Mauviel A.
RT Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.
RL J. Biol. Chem. 275:30226-30231 (2000).
RN [11]; RE0023953.
RX PUBMED: 12150994.
RA Chen C. R., Kang Y., Siegel P. M., Massague J.
RT E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
RL Cell 110:19-32 (2002).
RN [12]; RE0023955.
RX PUBMED: 11691834.
RA Stroschein S. L., Bonni S., Wrana J. L., Luo K.
RT Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.
RL Genes Dev. 15:2822-2836 (2001).
RN [13]; RE0024466.
RX PUBMED: 14527958.
RA Funaba M., Ikeda T., Murakami M., Ogawa K., Tsuchida K., Sugino H., Abe M.
RT Transcriptional activation of mouse mast cell Protease-7 by activin and transforming growth factor-beta is inhibited by microphthalmia-associated transcription factor.
RL J. Biol. Chem. 278:52032-52041 (2003).
RN [14]; RE0027706.
RX PUBMED: 10518526.
RA Song C. Z., Tian X., Gelehrter T. D.
RT Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3.
RL Proc. Natl. Acad. Sci. USA 96:11776-81 (1999).
RN [15]; RE0027895.
RX PUBMED: 11248024.
RA Kang H. Y., Lin H. K., Hu Y. C., Yeh S., Huang K. E., Chang C.
RT From transforming growth factor-beta signaling to androgen action: Identification of Smad3 as an androgen receptor coregulator in prostate cancer cells.
RL Proc. Natl. Acad. Sci. USA 98:3018-3023 (2001).
RN [16]; RE0029423.
RX PUBMED: 9886263.
RA Chen S. J., Yuan W., Mori Y., Levenson A., Trojanowska M., Varga J.
RT Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3.
RL J. Invest. Dermatol 112:49-57 (1999).
RN [17]; RE0029851.
RX PUBMED: 12270924.
RA Leivonen S. K., Chantry A., Hakkinen L., Han J., Kahari V. M.
RT Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways.
RL J. Biol. Chem. 277:46338-46 (2002).
RN [18]; RE0030300.
RX PUBMED: 12743039.
RA Postigo A. A., Depp J. L., Taylor J. J., Kroll K. L.
RT Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.
RL EMBO J. 22:2453-62 (2003).
RN [19]; RE0030416.
RX PUBMED: 12764135.
RA He J., Tegen S. B., Krawitz A. R., Martin G. S., Luo K.
RT The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.
RL J. Biol. Chem. 278:30540-7 (2003).
RN [20]; RE0030484.
RX PUBMED: 12917425.
RA Higashi K., Inagaki Y., Fujimori K., Nakao A., Kaneko H., Nakatsuka I.
RT Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3.
RL J. Biol. Chem. 278:43470-9 (2003).
RN [21]; RE0030770.
RX PUBMED: 14742269.
RA Saika S., Kono-Saika S., Ohnishi Y., Sato M., Muragaki Y., Ooshima A., Flanders K. C., Yoo J., Anzano M., Liu C. Y., Kao W. W., Roberts A. B.
RT Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.
RL Am. J. Pathol. 164:651-63 (2004).
RN [22]; RE0030812.
RX PUBMED: 12483531.
RA Kadakia M., Brown T. L., McGorry M. M., Berberich S. J.
RT MdmX inhibits Smad transactivation.
RL Oncogene 21:8776-85 (2002).
RN [23]; RE0030891.
RX PUBMED: 14654367.
RA Qiu P., Feng X. H., Li L.
RT Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation.
RL J. Mol. Cell. Cardiol. 35:1407-20 (2003).
RN [24]; RE0030982.
RX PUBMED: 15084259.
RA Seoane J., Le H. V., Shen L., Anderson S. A., Massague J.
RT Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
RL Cell 117:211-23 (2004).
RN [25]; RE0031943.
RX PUBMED: 15241418.
RA Matsuura I., Denissova N. G., Wang G., He D., Long J., Liu F.
RT Cyclin-dependent kinases regulate the antiproliferative function of Smads.
RL Nature 430:226-31 (2004).
RN [26]; RE0032548.
RX PUBMED: 15107418.
RA Kim B. C., van Gelder H., Kim T. A., Lee H. J., Baik K. G., Chun H. H., Lee D. A., Choi K. S., Kim S. J.
RT Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.
RL J. Biol. Chem. 279:28458-65 (2004).
RN [27]; RE0033128.
RX PUBMED: 15051726.
RA Feng L., Guedes S., Wang T.
RT Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways.
RL J. Biol. Chem. 279:29681-90 (2004).
RN [28]; RE0033367.
RX PUBMED: 11741538.
RA Wan Y., Liu X., Kirschner M. W.
RT The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.
RL Mol. Cell 8:1027-39 (2001).
RN [29]; RE0033607.
RX PUBMED: 12524424.
RA Choy L., Derynck R.
RT Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.
RL J. Biol. Chem. 278:9609-19 (2003).
RN [30]; RE0033609.
RX PUBMED: 12551947.
RA Grinberg A. V., Kerppola T.
RT Both Max and TFE3 cooperate with Smad proteins to bind the plasminogen activator inhibitor-1 promoter, but they have opposite effects on transcriptional activity.
RL J. Biol. Chem. 278:11227-36 (2003).
RN [31]; RE0033675.
RX PUBMED: 9651680.
RA Stockwell B. R., Schreiber S. L.
RT Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers.
RL Curr. Biol. 8:761-70 (1998).
RN [32]; RE0034213.
RX PUBMED: 15292219.
RA Lei S., Dubeykovskiy A., Chakladar A., Wojtukiewicz L., Wang T. C.
RT The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
RL J. Biol. Chem. 279:42492-502 (2004).
RN [33]; RE0034512.
RX PUBMED: 15144564.
RA Nourry C., Maksumova L., Pang M., Liu X., Wang T.
RT Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.
RL BMC Cell Biol. 5:20 (2004).
RN [34]; RE0037868.
RX PUBMED: 10574984.
RA Rich J. N., Zhang M., Datto M. B., Bigner D. D., Wang X. F.
RT Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines
RL J. Biol. Chem. 274:35053-8 (1999).
RN [35]; RE0038295.
RX PUBMED: 10973958.
RA Werner F., Jain M. K., Feinberg M. W., Sibinga N. E., Pellacani A., Wiesel P., Chin M. T., Topper J. N., Perrella M. A., Lee M. E.
RT Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via smad3
RL J. Biol. Chem. 275:36653-8 (2000).
RN [36]; RE0039135.
RX PUBMED: 14657019.
RA Koinuma D., Shinozaki M., Komuro A., Goto K., Saitoh M., Hanyu A., Ebina M., Nukiwa T., Miyazawa K., Imamura T., Miyazono K.
RT Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
RL EMBO J. 22:6458-70 (2003).
RN [37]; RE0040112.
RX PUBMED: 12023901.
RA Chen F., Ogawa K., Liu X., Stringfield T. M., Chen Y.
RT Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit
RL Biochem. J. 364:571-7 (2002).
RN [38]; RE0040941.
RX PUBMED: 9920806.
RA Watanabe R., Yamada Y., Ihara Y., Someya Y., Kubota A., Kagimoto S., Kuroe A., Iwakura T., Shen Z. P., Inada A., Adachi T., Ban N., Miyawaki K., Sunaga Y., Tsuda K., Seino Y.
RT The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals
RL Biochem. Biophys. Res. Commun. 254:707-12 (1999).
RN [39]; RE0041180.
RX PUBMED: 12815042.
RA Imoto S., Sugiyama K., Muromoto R., Sato N., Yamamoto T., Matsuda T.
RT Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
RL J. Biol. Chem. 278:34253-8 (2003).
RN [40]; RE0041657.
RX PUBMED: 11359933.
RA Fukuchi M., Imamura T., Chiba T., Ebisawa T., Kawabata M., Tanaka K., Miyazono K.
RT Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
RL Mol. Biol. Cell 12:1431-43 (2001).
RN [41]; RE0041858.
RX PUBMED: 12504596.
RA Docagne F., Nicole O., Gabriel C., Fernandez-Monreal M., Lesne S., Ali C., Plawinski L., Carmeliet P., Mackenzie E. T., Buisson A., Vivien D.
RT Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis
RL Mol. Cell. Neurosci. 21:634-44 (2002).
RN [42]; RE0041859.
RX PUBMED: 11306568.
RA Liberati N. T., Moniwa M., Borton A. J., Davie J. R., Wang X. F.
RT An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*
RL J. Biol. Chem. 276:22595-603 (2001).
RN [43]; RE0041860.
RX PUBMED: 11906909.
RA Tomic D., Brodie S. G., Deng C., Hickey R. J., Babus J. K., Malkas L. H., Flaws J. A.
RT Smad 3 may regulate follicular growth in the mouse ovary
RL Biol. Reprod. 66:917-23 (2002).
RN [44]; RE0041861.
RX PUBMED: 15001984.
RA Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., Tamaki K.
RT Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
RL Oncogene 23:1656-67 (2004).
RN [45]; RE0041862.
RX PUBMED: 11555647.
RA Matsuda T., Yamamoto T., Muraguchi A., Saatcioglu F.
RT Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3
RL J. Biol. Chem. 276:42908-14 (2001).
RN [46]; RE0041873.
RX PUBMED: 11331591.
RA Alliston T., Choy L., Ducy P., Karsenty G., Derynck R.
RT TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
RL EMBO J. 20:2254-72 (2001).
RN [47]; RE0042302.
RX PUBMED: 11711431.
RA Liu D., Black B. L., Derynck R.
RT TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
RL Genes Dev. 15:2950-66 (2001).
RN [48]; RE0042424.
RX PUBMED: 11571638.
RA Bartholin L., Maguer-Satta V., Hayette S., Martel S., Gadoux M., Bertrand S., Corbo L., Lamadon C., Morera A. M., Magaud J. P., Rimokh R.
RT FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins
RL Oncogene 20:5409-19 (2001).
RN [49]; RE0042823.
RX PUBMED: 14623893.
RA Costamagna E., Garcia B., Santisteban P.
RT The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene
RL J. Biol. Chem. 279:3439-46 (2004).
RN [50]; RE0042991.
RX PUBMED: 11274402.
RA Kaji H., Canaff L., Lebrun J. J., Goltzman D., Hendy G. N.
RT Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling
RL Proc. Natl. Acad. Sci. USA 98:3837-42 (2001).
RN [51]; RE0042994.
RX PUBMED: 14651998.
RA Warner D. R., Roberts E. A., Greene R. M., Pisano M. M.
RT Identification of novel Smad binding proteins
RL Biochem. Biophys. Res. Commun. 312:1185-90 (2003).
RN [52]; RE0042995.
RX PUBMED: 14729983.
RA Qing J., Liu C., Choy L., Wu R. Y., Pagano J. S., Derynck R.
RT Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter
RL Mol. Cell. Biol. 24:1411-25 (2004).
RN [53]; RE0042996.
RX PUBMED: 11058129.
RA Itoh S., Ericsson J., Nishikawa Ji, Heldin C. H., Dijke Pt.
RT The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
RL Nucleic Acids Res. 28:4291-8 (2000).
RN [54]; RE0042998.
RX PUBMED: 15048128.
RA Remy I., Montmarquette A., Michnick S. W.
RT PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
RL Nat. Cell Biol. 6:358-65 (2004).
RN [55]; RE0043127.
RX PUBMED: 15265946.
RA Bonniaud P., Kolb M., Galt T., Robertson J., Robbins C., Stampfli M., Lavery C., Margetts P. J., Roberts A. B., Gauldie J.
RT Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis
RL J. Immunol. 173:2099-108 (2004).
RN [56]; RE0043321.
RX PUBMED: 14612439.
RA Lee H. J., Lee J. K., Miyake S., Kim S. J.
RT A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes
RL J. Biol. Chem. 279:2666-72 (2004).
RN [57]; RE0043600.
RX PUBMED: 15104092.
RA Conery A. R., Cao Y., Thompson E. A., Townsend C. M. Jr, Ko T. C., Luo K.
RT Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis
RL Nat. Cell Biol. 6:366-72 (2004).
RN [58]; RE0044240.
RX PUBMED: 12370310.
RA Jiao K., Zhou Y., Hogan B. L.
RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
RL Mol. Cell. Biol. 22:7633-44 (2002).
RN [59]; RE0046995.
RX PUBMED: 15221015.
RA Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
RT Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
RL Oncogene 23:6914-23 (2004).
RN [60]; RE0047163.
RX PUBMED: 14612401.
RA Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Janne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G.
RT Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth
RL Mol. Cell. Biol. 23:8563-75 (2003).
RN [61]; RE0047371.
RX PUBMED: 15623506.
RA Furumatsu T., Tsuda M., Taniguchi N., Tajima Y., Asahara H.
RT Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment.
RL J. Biol. Chem. 280:8343-8350 (2005).
RN [62]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [63]; RE0047898.
RX PUBMED: 9843199.
RA Liu F., Massague J., Ruiz i Altaba A.
RT Carboxy-terminally truncated Gli3 proteins associate with Smads.
RL Nat. Genet. 20:325-326 (1998).
RN [64]; RE0047923.
RX PUBMED: 15798217.
RA Ray D., Terao Y., Nimbalkar D., Chu L. H., Donzelli M., Tsutsui T., Zou X., Ghosh A. K., Varga J., Draetta G. F., Kiyokawa H.
RT Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.
RL Mol. Cell. Biol. 25:3338-3347 (2005).
RN [65]; RE0047924.
RX PUBMED: 11387212.
RA Hocevar B. A., Smine A., Xu X. X., Howe P. H.
RT The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
RL EMBO J. 20:2789-2801 (2001).
RN [66]; RE0047925.
RX PUBMED: 11427533.
RA Melhuish T. A., Gallo C. M., Wotton D.
RT TGIF2 interacts with histone deacetylase 1 and represses transcription.
RL J. Biol. Chem. 276:32109-32114 (2001).
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RA Warner D. R., Bhattacherjee V., Yin X., Singh S., Mukhopadhyay P., Pisano M. M., Greene R. M.
RT Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.
RL Biochem. Biophys. Res. Commun. 324:70-76 (2004).
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RA Qiu P., Ritchie R. P., Fu Z., Cao D., Cumming J., Miano J. M., Wang D. Z., Li H. J., Li L.
RT Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo.
RL Circ. Res. 97:983-991 (2005).
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RA Lee D. K., Kim B. C., Brady J. N., Jeang K. T., Kim S. J.
RT Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element.
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RA Bailey J. S., Rave-Harel N., McGillivray S. M., Coss D., Mellon P. L.
RT Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.
RL Mol. Endocrinol. 18:1158-1170 (2004).
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RA Choi S. H., Hwang S. B.
RT Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.
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RA Simonsson M., Kanduri M., Gronroos E., Heldin C. H., Ericsson J.
RT The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.
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RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
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RA Inoue Y., Itoh Y., Abe K., Okamoto T., Daitoku H., Fukamizu A., Onozaki K., Hayashi H.
RT Smad3 is acetylated by p300/CBP to regulate its transactivation activity.
RL Oncogene 26:500-508 (2007).
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RA Seong H. A., Jung H., Choi H. S., Kim K. T., Ha H.
RT Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.
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RA Cordenonsi M., Montagner M., Adorno M., Zacchigna L., Martello G., Mamidi A., Soligo S., Dupont S., Piccolo S.
RT Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
RL Science 315:840-843 (2007).
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RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S.
RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
RL Oncogene 24:2289-2297 (2005).
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RA Suszko M. I., Antenos M., Balkin D. M., Woodruff T. K.
RT Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription.
RL Mol. Cell. Endocrinol. 281:27-36 (2008).
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RA Yan X., Zhang J., Sun Q., Tuazon P. T., Wu X., Traugh J. A., Chen Y. G.
RT p21-activated kinase 2 (PAK2) inhibits TGF-beta signaling in madine-darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.
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RA Yao X., Chen X., Cottonham C., Xu L.
RT Preferential utilization of Imp7/8 in nuclear import of Smads.
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RA Xin H., Xu X., Li L., Ning H., Rong Y., Shang Y., Wang Y., Fu X. Y., Chang Z.
RT CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.
RL J. Biol. Chem. 280:20842-20850 (2005).
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