AC T08197
AS T02940.
XX
ID T08197
XX
DT 30.08.2005 (created); sla.
DT 10.05.2016 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA FOXO3a
XX
SY AF6q21; AF6q21 protein; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3A; Forkhead in rhabdomyosarcoma-like 1; FOXO2; Foxo3; FOXO3A; MGC12739; MGC31925.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004640 FOXO3; HGNC: Foxo3.
XX
CL C0023; fork head.
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SZ 673 AA; 71.3 kDa (cDNA) (calc.).
XX
SQ MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE
SQ EDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS
SQ GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTL
SQ SQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG
SQ GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS
SQ DELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK
SQ PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG
SQ SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS
SQ HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQT
SQ QGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP
SQ VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFT
SQ GAKQASSQSWVPG
XX
SC translated from EMBL:AF032886
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FT 15 570 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 32 32 
Akt phosphorylation site [9].
FT 134 249 
PF00250; Fork head domain.
FT 148 257 
forkhead domain [9].
FT 155 245 
SM00339; forkneu4.
FT 157 251 
PS50039; FORK_HEAD_3.
FT 253 253 
Akt phosphorylation site [9].
XX
IN T14323 Skp2; Mammalia.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
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MX M01137 V$FOXO3A_Q1.
MX M07287 V$FOXO3A_Q3.
MX M02270 V$FOXO3_02.
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BS R12972.
BS R26360.
BS R29219.
BS R26296.
BS R26586.
BS R26328.
BS R26279.
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DR TRANSPATH: MO000056398.
DR EMBL: AF032886;
DR EMBL: AF041336;
DR UniProtKB: O43524;
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RN [1]; RE0013367.
RX PUBMED: 9852958.
RA DaSilva L., Kirken R. A., Taub D. D., Evans G. A., Duhe R. J., Bailey M. A., Farrar W. L.
RT Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family
RL Gene 221:135-142 (1998).
RN [2]; RE0025253.
RX PUBMED: 15458387.
RA Van Den Heuvel A. P., Schulze A., Burgering B. M.
RT Direct control of caveolin-1 expression by FOXO transcription factors.
RL Biochem. J. 385:795-802 (2004).
RN [3]; RE0030982.
RX PUBMED: 15084259.
RA Seoane J., Le H. V., Shen L., Anderson S. A., Massague J.
RT Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
RL Cell 117:211-23 (2004).
RN [4]; RE0032086.
RX PUBMED: 12027802.
RA Nadal A., Marrero P. F., Haro D.
RT Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1.
RL Biochem. J. 366:289-97 (2002).
RN [5]; RE0051909.
RX PUBMED: 18204439.
RA Yang J. Y., Zong C. S., Xia W., Yamaguchi H., Ding Q., Xie X., Lang J. Y., Lai C. C., Chang C. J., Huang W. C., Huang H., Kuo H. P., Lee D. F., Li L. Y., Lien H. C., Cheng X., Chang K. J., Hsiao C. D., Tsai F. J., Tsai C. H., Sahin A. A., Muller W. J., Mills G. B., Yu D., Hortobagyi G. N., Hung M. C.
RT ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
RL Nat. Cell Biol. 10:138-148 (2008).
RN [6]; RE0065073.
RX PUBMED: 19056725.
RA Park S., Guo J., Kim D., Cheng J. Q.
RT Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway.
RL J. Biol. Chem. 284:2187-2193 (2009).
RN [7]; RE0066887.
RX PUBMED: 20404331.
RA Brault J. J., Jespersen J. G., Goldberg A. L.
RT PGC-1{alpha} or PGC-1{beta} (peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} or 1{beta}) overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
RL J. Biol. Chem. 285:19460-19471 (2010).
RN [8]; RE0070735.
RX PUBMED: 20110348.
RA Singh A., Ye M., Bucur O., Zhu S., Tanya Santos M., Rabinovitz I., Wei W., Gao D., Hahn W. C., Khosravi-Far R.
RT Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
RL Mol. Biol. Cell 21:1140-1152 (2010).
RN [9]; RE0015966.
RX PUBMED: 10102273.
RA Brunet A., Bonni A., Zigmond M. J., Lin M. Z., Juo P., Hu L. S., Anderson M. J., Arden K. C., Blenis J., Greenberg M. E.
RT Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
RL Cell 96:857-868 (1999).
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