AC T13998
XX
ID T13998
XX
DT 10.03.2005 (created); nvo.
DT 14.05.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA Smad4
XX
SY DPC4 (Deleted in pancreatic cancer); SMAD-4.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09248 AML2-isoform1; human, Homo sapiens.
IN T10452 beta-adaptin2; mouse, Mus musculus.
IN T14513 beta-catenin; Mammalia.
IN T23092 BF-1; Mammalia.
IN T15204 brca1; Mammalia.
IN T17201 BTEB2; Mammalia.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T04643 c-Ski; human, Homo sapiens.
IN T09410 C/EBPbeta; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T15118 CBP; Mammalia.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T16691 DP-1; Mammalia.
IN T10751 E2F-4; Mammalia.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T08515 ER-beta; human, Homo sapiens.
IN T16696 FoxH1; Mammalia.
IN T09104 FOXO1A; mouse, Mus musculus.
IN T08197 FOXO3a; human, Homo sapiens.
IN T03403 foxo4; human, Homo sapiens.
IN T08629 GATA-4; Mammalia.
IN T30499 gli3; Mammalia.
IN T16501 GLI; Mammalia.
IN T08343 HDAC1; human, Homo sapiens.
IN T05490 Hic-5; human, Homo sapiens.
IN T10516 HIF-1alpha; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T10510 JunB; Mammalia.
IN T09447 JunD; Mammalia.
IN T09551 LEF-1; Mammalia.
IN T19713 NF-1A; Mammalia.
IN T19712 NF-1B; Mammalia.
IN T30989 NF-1C; Mammalia.
IN T15389 NF-IX; Mammalia.
IN T14258 Nkx3-2; chick, Gallus gallus.
IN T10542 p300; mouse, Mus musculus.
IN T23091 p300; Mammalia.
IN T13888 pax6; Mammalia.
IN T09984 Prep-1; Mammalia.
IN T08914 Smad1; mouse, Mus musculus.
IN T10783 Smad1; Mammalia.
IN T04273 Smad2; mouse, Mus musculus.
IN T24830 Smad2; Mammalia.
IN T09072 Smad3; mouse, Mus musculus.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
IN T22207 Smad5; Mammalia.
IN T08326 Sp1; Mammalia.
IN T08951 STAT1; mouse, Mus musculus.
IN T09192 TFEA; mouse, Mus musculus.
IN T17416 tfeb; Mammalia.
IN T27177 Tsc-22-isoform2; human, Homo sapiens.
IN T22793 znf8; mouse, Mus musculus.
XX
MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R62324.
BS R32454.
BS R67615.
BS R24229.
BS R24230.
BS R36234.
BS R29095.
BS R29096.
BS R29097.
BS R39153.
BS R39079.
BS R39080.
BS R27486.
BS R37518.
BS R37520.
BS R10079.
BS R36862.
BS R26158.
BS R26160.
BS R26161.
BS R71637.
BS R10056.
BS R10057.
BS R34526.
BS R36216.
BS R36221.
BS R30936.
BS R23097.
BS R30601.
BS R30602.
BS R24448.
BS R34773.
BS R36228.
BS R10066.
BS R34784.
BS R36850.
BS R36851.
BS R36852.
BS R36854.
BS R24218.
XX
DR TRANSPATH: MO000046898.
DR TRANSCOMPEL: C00194.
DR TRANSCOMPEL: C00243.
DR TRANSCOMPEL: C00548.
XX
RN [1]; RE0015642.
RX PUBMED: 9335505.
RA Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K.
RT Smad6 inhibits signalling by the TGF-beta superfamily
RL Nature 389:622-626 (1997).
RN [2]; RE0016085.
RX PUBMED: 10636916.
RA de Caestecker M. P., Yahata T., Wang D., Parks W. T., Huang S., Hill C. S., Shioda T., Roberts A. B., Lechleider R. J.
RT The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.
RL J. Biol. Chem. 275:2115-2122 (2000).
RN [3]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
RN [4]; RE0016410.
RX PUBMED: 10485843.
RA Luo K., Stroschein S. L., Wang W., Chen D., Martens E., Zhou S., Zhou Q.
RT The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.
RL Genes Dev. 13:2196-2206 (1999).
RN [5]; RE0016418.
RX PUBMED: 10531062.
RA Stroschein S. L., Wang W., Zhou S., Zhou Q., Luo K.
RT Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
RL Science 286:771-774 (1999).
RN [6]; RE0016518.
RX PUBMED: 9707553.
RA Shioda T., Lechleider R. J., Dunwoodie S. L., Li H., Yahata T., de Caestecker M. P., Fenner M. H., Roberts A. B., Isselbacher K. J.
RT Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
RL Proc. Natl. Acad. Sci. USA 95:9785-9790 (1998).
RN [7]; RE0023200.
RX PUBMED: 12631740.
RA Chou W. C., Prokova V., Shiraishi K., Valcourt U., Moustakas A., Hadzopoulou-Cladaras M., Zannis V. I., Kardassis D.
RT Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-beta-regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4.
RL Mol. Biol. Cell 14:1279-1294 (2003).
RN [8]; RE0027996.
RX PUBMED: 11278410.
RA Sasaki A., Masuda Y., Ohta Y., Ikeda K., Watanabe K.
RT Filamin associates with Smads and regulates transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:17871-7 (2001).
RN [9]; RE0029406.
RX PUBMED: 11854297.
RA Lai C. F., Cheng S. L.
RT Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells.
RL J. Biol. Chem. 277:15514-22 (2002).
RN [10]; RE0029423.
RX PUBMED: 9886263.
RA Chen S. J., Yuan W., Mori Y., Levenson A., Trojanowska M., Varga J.
RT Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3.
RL J. Invest. Dermatol 112:49-57 (1999).
RN [11]; RE0030216.
RX PUBMED: 12429655.
RA Peng B., Fleming J. B., Breslin T., Grau A. M., Fojioka S., Abbruzzese J. L., Evans D. B., Ayers D., Wathen K., Wu T., Robertson K. D., Chiao P. J.
RT Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
RL Clin. Cancer Res. 8:3628-38 (2002).
RN [12]; RE0030299.
RX PUBMED: 12740389.
RA Lee P. S., Chang C., Liu D., Derynck R.
RT Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.
RL J. Biol. Chem. 278:27853-63 (2003).
RN [13]; RE0030539.
RX PUBMED: 12813045.
RA Lin X., Liang M., Liang Y. Y., Brunicardi F. C., Feng X. H.
RT SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.
RL J. Biol. Chem. 278:31043-8 (2003).
RN [14]; RE0030812.
RX PUBMED: 12483531.
RA Kadakia M., Brown T. L., McGorry M. M., Berberich S. J.
RT MdmX inhibits Smad transactivation.
RL Oncogene 21:8776-85 (2002).
RN [15]; RE0030982.
RX PUBMED: 15084259.
RA Seoane J., Le H. V., Shen L., Anderson S. A., Massague J.
RT Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
RL Cell 117:211-23 (2004).
RN [16]; RE0032129.
RX PUBMED: 14691138.
RA Nawshad A., Hay E. D.
RT TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
RL J. Cell Biol. 163:1291-301 (2003).
RN [17]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [18]; RE0033607.
RX PUBMED: 12524424.
RA Choy L., Derynck R.
RT Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function.
RL J. Biol. Chem. 278:9609-19 (2003).
RN [19]; RE0033793.
RX PUBMED: 12707256.
RA Denton C. P., Zheng B., Evans L. A., Shi-wen X., Ong V. H., Fisher I., Lazaridis K., Abraham D. J., Black C. M., de Crombrugghe B.
RT Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
RL J. Biol. Chem. 278:25109-19 (2003).
RN [20]; RE0034213.
RX PUBMED: 15292219.
RA Lei S., Dubeykovskiy A., Chakladar A., Wojtukiewicz L., Wang T. C.
RT The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
RL J. Biol. Chem. 279:42492-502 (2004).
RN [21]; RE0037443.
RX PUBMED: 12167862.
RA Kato Y., Habas R., Katsuyama Y., Naar A. M., He X.
RT A component of the ARC/Mediator complex required for TGF beta/Nodal signalling
RL Nature 418:641-6 (2002).
RN [22]; RE0040635.
RX PUBMED: 14514699.
RA Ohshima T., Shimotohno K.
RT Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
RL J. Biol. Chem. 278:50833-42 (2003).
RN [23]; RE0041180.
RX PUBMED: 12815042.
RA Imoto S., Sugiyama K., Muromoto R., Sato N., Yamamoto T., Matsuda T.
RT Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
RL J. Biol. Chem. 278:34253-8 (2003).
RN [24]; RE0041243.
RX PUBMED: 12904571.
RA Long J., Matsuura I., He D., Wang G., Shuai K., Liu F.
RT Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
RL Proc. Natl. Acad. Sci. USA 100:9791-6 (2003).
RN [25]; RE0041364.
RX PUBMED: 14701756.
RA Li L., Xin H., Xu X., Huang M., Zhang X., Chen Y., Zhang S., Fu X. Y., Chang Z.
RT CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription
RL Mol. Cell. Biol. 24:856-64 (2004).
RN [26]; RE0041859.
RX PUBMED: 11306568.
RA Liberati N. T., Moniwa M., Borton A. J., Davie J. R., Wang X. F.
RT An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*
RL J. Biol. Chem. 276:22595-603 (2001).
RN [27]; RE0041862.
RX PUBMED: 11555647.
RA Matsuda T., Yamamoto T., Muraguchi A., Saatcioglu F.
RT Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3
RL J. Biol. Chem. 276:42908-14 (2001).
RN [28]; RE0042424.
RX PUBMED: 11571638.
RA Bartholin L., Maguer-Satta V., Hayette S., Martel S., Gadoux M., Bertrand S., Corbo L., Lamadon C., Morera A. M., Magaud J. P., Rimokh R.
RT FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins
RL Oncogene 20:5409-19 (2001).
RN [29]; RE0042425.
RX PUBMED: 12554780.
RA Suszko M. I., Lo D. J., Suh H., Camper S. A., Woodruff T. K.
RT Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin
RL Mol. Endocrinol. 17:318-32 (2003).
RN [30]; RE0043308.
RX PUBMED: 11152469.
RA Holmes A., Abraham D. J., Sa S., Shiwen X., Black C. M., Leask A.
RT CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
RL J. Biol. Chem. 276:10594-601 (2001).
RN [31]; RE0043321.
RX PUBMED: 14612439.
RA Lee H. J., Lee J. K., Miyake S., Kim S. J.
RT A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes
RL J. Biol. Chem. 279:2666-72 (2004).
RN [32]; RE0043707.
RX PUBMED: 15314162.
RA Liang M., Liang Y. Y., Wrighton K., Ungermannova D., Wang X. P., Brunicardi F. C., Liu X., Feng X. H., Lin X.
RT Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2
RL Mol. Cell. Biol. 24:7524-37 (2004).
RN [33]; RE0043708.
RX PUBMED: 11278805.
RA Puente E., Saint-Laurent N., Torrisani J., Furet C., Schally A. V., Vaysse N., Buscail L., Susini C.
RT Transcriptional Activation of Mouse sst2 Somatostatin Receptor Promoter by Transforming Growth Factor-beta. INVOLVEMENT OF Smad4
RL J. Biol. Chem. 276:13461-8 (2001).
RN [34]; RE0043709.
RX PUBMED: 14988407.
RA Wan M., Tang Y., Tytler E. M., Lu C., Jin B., Vickers S. M., Yang L., Shi X., Cao X.
RT Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1
RL J. Biol. Chem. 279:14484-7 (2004).
RN [35]; RE0043710.
RX PUBMED: 11879191.
RA Abdel-Wahab N., Wicks S. J., Mason R. M., Chantry A.
RT Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240
RL Biochem. J. 362:643-9 (2002).
RN [36]; RE0043711.
RX PUBMED: 14534532.
RA Duda D. G., Sunamura M., Lefter L. P., Furukawa T., Yokoyama T., Yatsuoka T., Abe T., Inoue H., Motoi F., Egawa S., Matsuno S., Horii A.
RT Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
RL Oncogene 22:6857-64 (2003).
RN [37]; RE0043944.
RX PUBMED: 15184872.
RA Jonckheere N., Perrais M., Mariette C., Batra S. K., Aubert J. P., Pigny P., Van Seuningen I.
RT A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis
RL Oncogene 23:5729-38 (2004).
RN [38]; RE0044240.
RX PUBMED: 12370310.
RA Jiao K., Zhou Y., Hogan B. L.
RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
RL Mol. Cell. Biol. 22:7633-44 (2002).
RN [39]; RE0047852.
RX PUBMED: 15881652.
RA Choi S. J., Moon J. H., Ahn Y. W., Ahn J. H., Kim D. U., Han T. H.
RT Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.
RL Mol. Cell. Biochem. 271:23-28 (2005).
RN [40]; RE0047877.
RX PUBMED: 11818334.
RA Wan M., Cao X., Wu Y., Bai S., Wu L., Shi X., Wang N., Cao X.
RT Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation.
RL EMBO Rep. 3:171-176 (2002).
RN [41]; RE0047884.
RX PUBMED: 14525983.
RA Wu K., Yang Y., Wang C., Davoli M. A., D'Amico M., Li A., Cveklova K., Kozmik Z., Lisanti M. P., Russell R. G., Cvekl A., Pestell R. G.
RT DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
RL J. Biol. Chem. 278:51673-51684 (2003).
RN [42]; RE0047898.
RX PUBMED: 9843199.
RA Liu F., Massague J., Ruiz i Altaba A.
RT Carboxy-terminally truncated Gli3 proteins associate with Smads.
RL Nat. Genet. 20:325-326 (1998).
RN [43]; RE0048120.
RX PUBMED: 12097320.
RA Lee D. K., Kim B. C., Brady J. N., Jeang K. T., Kim S. J.
RT Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element.
RL J. Biol. Chem. 277:33766-33775 (2002).
RN [44]; RE0048224.
RX PUBMED: 14764653.
RA Bailey J. S., Rave-Harel N., McGillivray S. M., Coss D., Mellon P. L.
RT Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.
RL Mol. Endocrinol. 18:1158-1170 (2004).
RN [45]; RE0048542.
RX PUBMED: 16580992.
RA Jin W., Takagi T., Kanesashi S. N., Kurahashi T., Nomura T., Harada J., Ishii S.
RT Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins.
RL Dev. Cell 10:461-471 (2006).
RN [46]; RE0048843.
RX PUBMED: 15637079.
RA Chang C. C., Lin D. Y., Fang H. I., Chen R. H., Shih H. M.
RT Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
RL J. Biol. Chem. 280:10164-10173 (2005).
RN [47]; RE0048990.
RX PUBMED: 16407286.
RA Choi S. H., Hwang S. B.
RT Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.
RL J. Biol. Chem. 281:7468-7478 (2006).
RN [48]; RE0049228.
RX PUBMED: 9722503.
RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
RL J. Biol. Chem. 273:22865-22868 (1998).
RN [49]; RE0049583.
RX PUBMED: 17327236.
RA Seong H. A., Jung H., Kim K. T., Ha H.
RT 3-phosphoinositide-dependent protein kinase-1 (PDK1) negatively regulates TGF-beta -induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
RL J. Biol. Chem. 282:12272-12289 (2007).
RN [50]; RE0051123.
RX PUBMED: 15735739.
RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S.
RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
RL Oncogene 24:2289-2297 (2005).
RN [51]; RE0066347.
RX PUBMED: 16885393.
RA Allen D. L., Unterman T. G.
RT Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors.
RL Am. J. Physiol. Cell Physiol. 292:C188-99 (2007).
RN [52]; RE0071318.
RX PUBMED: 14750902.
RA Long J., Wang G., He D., Liu F.
RT Repression of Smad4 transcriptional activity by SUMO modification.
RL Biochem. J. 379:23-29 (2004).
RN [53]; RE0073040.
RX PUBMED: 22393057.
RA Yan X., Zhang J., Sun Q., Tuazon P. T., Wu X., Traugh J. A., Chen Y. G.
RT p21-activated kinase 2 (PAK2) inhibits TGF-beta signaling in madine-darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.
RL J. Biol. Chem. 287:13705-13712 (2012).
RN [54]; RE0073068.
RX PUBMED: 18519565.
RA Yao X., Chen X., Cottonham C., Xu L.
RT Preferential utilization of Imp7/8 in nuclear import of Smads.
RL J. Biol. Chem. 283:22867-22874 (2008).
XX
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