TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T10751 XX ID T10751 XX DT 10.03.2005 (created); nvo. DT 18.02.2016 (updated); jmh. CO Copyright (C), QIAGEN. XX FA E2F-4 XX SY E2F transcription factor 4; E2F4. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T04074 brca1; human, Homo sapiens. IN T16987 BRG1; Mammalia. IN T16691 DP-1; Mammalia. IN T23091 p300; Mammalia. IN T25008 pRb; Mammalia. IN T13998 Smad4; Mammalia. XX MX M07380 V$E2F4_Q3. MX M02090 V$E2F4_Q6. MX M00050 V$E2F_02. MX M00803 V$E2F_Q2. MX M00918 V$E2F_Q3_01. MX M00919 V$E2F_Q4_01. MX M00939 V$E2F_Q4_02. MX M08875 V$E2F_Q4_03. MX M00920 V$E2F_Q6_01. XX BS R09600. BS R09601. BS R04382. BS R22115. BS R25613. XX DR TRANSPATH: MO000047189. XX RN [1]; RE0003318. RX PUBMED: 7958925. RA Beijersbergen R. L., Kerkhoven R. M., Zhu L., Carlee L., Voorhoeve P. M., Bernards R. RT E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo RL Genes Dev. 8:2680-2690 (1994). RN [2]; RE0010381. RX PUBMED: 7705662. RA Vairo G., Livingston D. M., Ginsberg D. RT Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth supression by different retinoblastoma protein family members RL Genes Dev. 9:869-881 (1995). RN [3]; RE0023953. RX PUBMED: 12150994. RA Chen C. R., Kang Y., Siegel P. M., Massague J. RT E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. RL Cell 110:19-32 (2002). RN [4]; RE0026750. RX PUBMED: 10982822. RA Wu L., Goodwin E. C., Naeger L. K., Vigo E., Galaktionov K., Helin K., DiMaio D. RT E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. RL Mol. Cell. Biol. 20:7059-67 (2000). RN [5]; RE0031299. RX PUBMED: 12411495. RA Schlisio S., Halperin T., Vidal M., Nevins J. R. RT Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. RL EMBO J. 21:5775-86 (2002). RN [6]; RE0037492. RX PUBMED: 11313936. RA O'Connor R. J., Schaley J. E., Feeney G., Hearing P. RT The p107 tumor suppressor induces stable E2F DNA binding to repress target promoters RL Oncogene 20:1882-91 (2001). RN [7]; RE0037754. RX PUBMED: 12198120. RA Kobayashi M., Taniura H., Yoshikawa K. RT Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells RL J. Biol. Chem. 277:42128-35 (2002). RN [8]; RE0039011. RX PUBMED: 11418595. RA Lang S. E., McMahon S. B., Cole M. D., Hearing P. RT E2F transcriptional activation requires TRRAP and GCN5 cofactors RL J. Biol. Chem. 276:32627-34 (2001). RN [9]; RE0044175. RX PUBMED: 9438389. RA Strom D. K., Cleveland J. L., Chellappan S., Nip J., Hiebert S. W. RT E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation RL Cell Growth Differ. 9:59-69 (1998). RN [10]; RE0047166. RX PUBMED: 15195143. RA Yoshida K., Inoue I. RT Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor RL Oncogene 23:6250-60 (2004). RN [11]; RE0047542. RX PUBMED: 9724731. RA Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., Trouche D. RT The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. RL Proc. Natl. Acad. Sci. USA 95:10493-10498 (1998). RN [12]; RE0048082. RX PUBMED: 9244350. RA Wang H., Shao N., Ding Q. M., Cui J., Reddy E. S., Rao V. N. RT BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. RL Oncogene 15:143-157 (1997). XX //