AC T09072
XX
ID T09072
XX
DT 14.06.2006 (created); jag.
DT 05.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA Smad3
XX
SY Smad-3.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002404 Smad3.
XX
CL C0041; SMAD.
XX
SZ 425 AA; 48.1 kDa (cDNA) (calc.).
XX
SQ MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
SQ NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
SQ CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
SQ PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
SQ NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
SQ GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
SQ EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
SQ CSSVS
XX
SC translated from EMBL #AB008192
XX
FT 1 145 
MH1 domain [1].
FT 10 136 
PS51075; MH1.
FT 26 134 
SM00523; dwAneu5.
FT 28 131 
PF03165; MH1 domain.
FT 146 231 
Linker region [1].
FT 226 403 
PF03166; MH2 domain.
FT 230 401 
SM00524; DWB.
FT 232 421 
MH2 domain [1].
FT 232 425 
PS51076; MH2.
FT 422 425 
SSXS motif [1].
XX
IN T17460 IRF-3; Mammalia.
IN T10783 Smad1; Mammalia.
IN T24830 Smad2; Mammalia.
IN T13998 Smad4; Mammalia.
IN T04759 STAT1; human, Homo sapiens.
XX
MX M02794 V$SMAD3_03.
MX M00701 V$SMAD3_Q6.
MX M01888 V$SMAD3_Q6_01.
MX M07429 V$SMAD3_Q6_02.
MX M02898 V$SMAD4_04.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R09967.
BS R25469.
BS R68120.
BS R68122.
BS R37792.
XX
DR TRANSPATH: MO000082956.
DR TRANSCOMPEL: C00557.
DR TRANSCOMPEL: C00574.
DR EMBL: AB008192; AB008192.
DR UniProtKB: Q8BUN5;
XX
RN [1]; RE0015115.
RX PUBMED: 10767528.
RA Dick A., Mayr T., Bauer H., Meier A., Hammerschmidt M.
RT Cloning and characterization of zebrafish smad2, smad3 and smad4
RL Gene 246:69-80 (2000).
RN [2]; RE0015602.
RX PUBMED: 10331191.
RA Kano K., Notani A., Nam S. Y., Fujisawa M., Kurohmaru M., Hayashi Y.
RT Cloning and studies of the mouse cDNA encoding Smad3
RL J. Vet. Med. Sci. 61:213-219 (1999).
RN [3]; RE0015682.
RX PUBMED: 10064594.
RA Yang X., Letterio J. J., Lechleider R. J., Chen L., Hayman R., Gu H., Roberts A. B., Deng D.
RT Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
RL EMBO J. 18:1280-1291 (1999).
RN [4]; RE0015683.
RX PUBMED: 10082515.
RA Datto M. B., Frederick J. P., Pan L., Borton A. J., Zhuang Y., Wang X. F.
RT Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
RL Mol. Cell. Biol. 19:2495-2504 (1999).
RN [5]; RE0023194.
RX PUBMED: 12145309.
RA Norwitz E. R., Xu S., Xu J., Spiryda L. B., Park J. S., Jeong K. H., McGee E. A., Kaiser U. B.
RT Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene.
RL J. Biol. Chem. 277:37469-37478 (2002).
RN [6]; RE0031943.
RX PUBMED: 15241418.
RA Matsuura I., Denissova N. G., Wang G., He D., Long J., Liu F.
RT Cyclin-dependent kinases regulate the antiproliferative function of Smads.
RL Nature 430:226-31 (2004).
XX
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