AC T17460
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ID T17460
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DT 10.03.2005 (created); nvo.
DT 02.03.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA IRF-3
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SY Interferon Regulatory Factor 3; IRF-3; IRF3.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T15118 CBP; Mammalia.
IN T02936 FOXO1A; human, Homo sapiens.
IN T17460 IRF-3; Mammalia.
IN T23091 p300; Mammalia.
IN T19338 RFP; human, Homo sapiens.
IN T04273 Smad2; mouse, Mus musculus.
IN T09072 Smad3; mouse, Mus musculus.
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MX M01279 V$IRF3_Q3.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R14453.
BS R14452.
BS R14454.
BS R25968.
BS R26722.
BS R14802.
BS R66431.
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DR TRANSPATH: MO000047983.
DR TRANSCOMPEL: C00463.
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RN [1]; RE0016765.
RX PUBMED: 10938111.
RA Lin R., Genin P., Mamane Y., Hiscott J.
RT Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
RL Mol. Cell. Biol. 20:6342-6353 (2000).
RN [2]; RE0024005.
RX PUBMED: 14739303.
RA Han K. J., Su X., Xu L. G., Bin L. H., Zhang J., Shu H. B.
RT Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways.
RL J. Biol. Chem. 279:15652-15661 (2004).
RN [3]; RE0039482.
RX PUBMED: 11854279.
RA Malakhova O., Malakhov M., Hetherington C., Zhang D. E.
RT Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3
RL J. Biol. Chem. 277:14703-11 (2002).
RN [4]; RE0040343.
RX PUBMED: 10805757.
RA Kumar K. P., McBride K. M., Weaver B. K., Dingwall C., Reich N. C.
RT Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1
RL Mol. Cell. Biol. 20:4159-68 (2000).
RN [5]; RE0041914.
RX PUBMED: 15251447.
RA Zhang J., Xu L. G., Han K. J., Wei X., Shu H. B.
RT PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
RL FEBS Lett. 570:97-101 (2004).
RN [6]; RE0044092.
RX PUBMED: 11867762.
RA Karpova A. Y., Trost M., Murray J. M., Cantley L. C., Howley P. M.
RT Interferon regulatory factor-3 is an in vivo target of DNA-PK
RL Proc. Natl. Acad. Sci. USA 99:2818-23 (2002).
RN [7]; RE0050030.
RX PUBMED: 17460044.
RA Arimoto K., Takahashi H., Hishiki T., Konishi H., Fujita T., Shimotohno K.
RT Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
RL Proc. Natl. Acad. Sci. USA 104:7500-7505 (2007).
RN [8]; RE0053730.
RX PUBMED: 16153868.
RA Xu L. G., Wang Y. Y., Han K. J., Li L. Y., Zhai Z., Shu H. B.
RT VISA is an adapter protein required for virus-triggered IFN-beta signaling.
RL Mol. Cell 19:727-740 (2005).
RN [9]; RE0054266.
RX PUBMED: 15367631.
RA tenOever B. R., Sharma S., Zou W., Sun Q., Grandvaux N., Julkunen I., Hemmi H., Yamamoto M., Akira S., Yeh W. C., Lin R., Hiscott J.
RT Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
RL J. Virol. 78:10636-10649 (2004).
RN [10]; RE0054898.
RX PUBMED: 17823124.
RA Gatot J. S., Gioia R., Chau T. L., Patrascu F., Warnier M., Close P., Chapelle J. P., Muraille E., Brown K., Siebenlist U., Piette J., Dejardin E., Chariot A.
RT Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
RL J. Biol. Chem. 282:31131-31146 (2007).
RN [11]; RE0054945.
RX PUBMED: 15611223.
RA Sasai M., Oshiumi H., Matsumoto M., Inoue N., Fujita F., Nakanishi M., Seya T.
RT Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation.
RL J. Immunol. 174:27-30 (2005).
RN [12]; RE0054990.
RX PUBMED: 16281057.
RA Huang J., Liu T., Xu L. G., Chen D., Zhai Z., Shu H. B.
RT SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
RL EMBO J. 24:4018-4028 (2005).
RN [13]; RE0055029.
RX PUBMED: 18641315.
RA Higgs R., Ni Gabhann J., Ben Larbi N., Breen E. P., Fitzgerald K. A., Jefferies C. A.
RT The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.
RL J. Immunol. 181:1780-1786 (2008).
RN [14]; RE0055057.
RX PUBMED: 15502848.
RA Sarkar S. N., Peters K. L., Elco C. P., Sakamoto S., Pal S., Sen G. C.
RT Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.
RL Nat. Struct. Mol. Biol. 11:1060-1067 (2004).
RN [15]; RE0055079.
RX PUBMED: 16699525.
RA Saitoh T., Tun-Kyi A., Ryo A., Yamamoto M., Finn G., Fujita T., Akira S., Yamamoto N., Lu K. P., Yamaoka S.
RT Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
RL Nat. Immunol. 7:598-605 (2006).
RN [16]; RE0055095.
RX PUBMED: 18818394.
RA Liu X., Yao M., Li N., Wang C., Zheng Y., Cao X.
RT CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.
RL Blood 112:4961-4970 (2008).
RN [17]; RE0055118.
RX PUBMED: 16393995.
RA Zha J., Han K. J., Xu L. G., He W., Zhou Q., Chen D., Zhai Z., Shu H. B.
RT The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.
RL J. Immunol. 176:1072-1080 (2006).
RN [18]; RE0064916.
RX PUBMED: 15695821.
RA Schoenemeyer A., Barnes B. J., Mancl M. E., Latz E., Goutagny N., Pitha P. M., Fitzgerald K. A., Golenbock D. T.
RT The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
RL J. Biol. Chem. 280:17005-17012 (2005).
RN [19]; RE0065024.
RX PUBMED: 19893624.
RA Nakhaei P., Mesplede T., Solis M., Sun Q., Zhao T., Yang L., Chuang T. H., Ware C. F., Lin R., Hiscott J.
RT The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
RL PLoS Pathog. 5:e1000650 (2009).
RN [20]; RE0066125.
RX PUBMED: 17785777.
RA Osterlund P. I., Pietila T. E., Veckman V., Kotenko S. V., Julkunen I.
RT IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes.
RL J. Immunol. 179:3434-3442 (2007).
RN [21]; RE0068522.
RX PUBMED: 18849341.
RA Sanada T., Takaesu G., Mashima R., Yoshida R., Kobayashi T., Yoshimura A.
RT FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
RL J. Biol. Chem. 283:33858-33864 (2008).
RN [22]; RE0068604.
RX PUBMED: 18375758.
RA Wang Z., Choi M. K., Ban T., Yanai H., Negishi H., Lu Y., Tamura T., Takaoka A., Nishikura K., Taniguchi T.
RT Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
RL Proc. Natl. Acad. Sci. USA 105:5477-5482 (2008).
RN [23]; RE0069876.
RX PUBMED: 17618271.
RA Takaoka A., Wang Z., Choi M. K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., Taniguchi T.
RT DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
RL Nature 448:501-505 (2007).
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