AC T04273
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ID T04273
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DT 30.01.2001 (created); dkl.
DT 05.02.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Smad2
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SY HMAD-2; MADH2; Smad-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002384 Smad2.
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CL C0041; SMAD; 7.1.1.1.2.
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SF +/- mutants are viable, healthy and fertile [2];
SF MH2 domain contains a central beta sandwich, with a three helix bundle (H3, H4, H5) and a single strand (B1�) on one end, and a loop-helix region (L1, L2, L3, H1) on the other end [3];
SF specific interaction of five AAs (N381, W368, Y366, I341, F346) with SARA [3];
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CP variety of cell types; pituitary gonadotropes [7].
EX mouse, Mus musculus,,,embryo; detectable; subcellular extraction of proteins; [4].
EX mouse, Mus musculus,,,embryo; detectable; subcellular extraction of proteins; [4].
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FF SB-431542 decreases the TGF-beta induced phosphorylation of Smad2 in AKR-2B cells [9];
FF activates gene transcription in response to activin;
FF required for early embryonic development, and its loss results in early postimplantation lethality [2];
FF is required for egg cylinder elongation, for gastrulation and for mesoderm induction [2];
FF it is proposed that Smad2 and Smad4 function cooperatively in egg cylinder formation [2];
FF -/- mutant embryos at E6.5 were smaller with a pronounced reduction in the extraembryonic portion of the egg cylinders and did not contain extraembryonic ecto- or endoderm [2];
FF at E7.5 -/- mutant embryos do not contain headfold and primitive streak [2];
FF in pituitary gonadotropes, is located in cytoplasm under basal conditions and translocated into the nucleus after stimulation with activin [7];
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IN T17460 IRF-3; Mammalia.
IN T31925 Oligo1; Mammalia.
IN T02235 PEBP2alphaB1; mouse, Mus musculus.
IN T06379 PML; mouse, Mus musculus.
IN T04864 SIP1; mouse, Mus musculus.
IN T04254 Smad1; mouse, Mus musculus.
IN T34106 Smad1{p}; mouse, Mus musculus.
IN T05067 Smad4; mouse, Mus musculus.
IN T13998 Smad4; Mammalia.
IN T04759 STAT1; human, Homo sapiens.
IN T20152 Trim33; mouse, Mus musculus.
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MX M03580 V$SMAD2_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R23469.
BS R66072.
BS R30936.
BS R33295.
BS R33294.
BS R10063.
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DR TRANSPATH: MO000020648.
DR TRANSCOMPEL: C00241.
DR UniProtKB: Q62432; SMA2_MOUSE.
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RN [1]; RE0015115.
RX PUBMED: 10767528.
RA Dick A., Mayr T., Bauer H., Meier A., Hammerschmidt M.
RT Cloning and characterization of zebrafish smad2, smad3 and smad4
RL Gene 246:69-80 (2000).
RN [2]; RE0015684.
RX PUBMED: 9689088.
RA Weinstein M., Yang X., Li C., Xu X., Gotay J., Deng C. X.
RT Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
RL Proc. Natl. Acad. Sci. USA 95:9378-9383 (1998).
RN [3]; RE0016216.
RX PUBMED: 10615055.
RA Wu G., Chen Y. G., Ozdamar B., Gyuricza C. A., Chong P. A., Wrana J. L., Massague J., Shi Y.
RT Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
RL Science 287:92-97 (2000).
RN [4]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
RN [5]; RE0020663.
RX PUBMED: 10224135.
RA Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T.
RT Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
RL J. Biol. Chem. 274:13637-13642 (1999).
RN [6]; RE0022866.
RX PUBMED: 11927558.
RA Goumans M. J., Valdimarsdottir G., Itoh S., Rosendahl A., Sideras P., ten Dijke P.
RT Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors.
RL EMBO J. 21:1743-1753 (2002).
RN [7]; RE0023194.
RX PUBMED: 12145309.
RA Norwitz E. R., Xu S., Xu J., Spiryda L. B., Park J. S., Jeong K. H., McGee E. A., Kaiser U. B.
RT Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene.
RL J. Biol. Chem. 277:37469-37478 (2002).
RN [8]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [9]; RE0052119.
RX PUBMED: 16314499.
RA Zhu Q., Pearson-White S., Luo K.
RT Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.
RL Mol. Cell. Biol. 25:10731-10744 (2005).
RN [10]; RE0052975.
RX PUBMED: 16120603.
RA Grimm S. L., Contreras A., Barcellos-Hoff M. H., Rosen J. M.
RT Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice.
RL J. Biol. Chem. 280:36301-36309 (2005).
RN [11]; RE0068150.
RX PUBMED: 16543948.
RA Dillon S., Agrawal S., Banerjee K., Letterio J., Denning T. L., Oswald-Richter K., Kasprowicz D. J., Kellar K., Pare J., Van Dyke T., Ziegler S., Unutmaz D., Pulendran B.
RT Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
RL J. Clin. Invest. 116:916-928 (2006).
RN [12]; RE0069543.
RX PUBMED: 18758450.
RA Sorrentino A., Thakur N., Grimsby S., Marcusson A., von Bulow V., Schuster N., Zhang S., Heldin C. H., Landstrom M.
RT The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
RL Nat. Cell Biol. 10:1199-1207 (2008).
RN [13]; RE0071379.
RX PUBMED: 21493862.
RA Holm T. M., Habashi J. P., Doyle J. J., Bedja D., Chen Y., van Erp C., Lindsay M. E., Kim D., Schoenhoff F., Cohn R. D., Loeys B. L., Thomas C. J., Patnaik S., Marugan J. J., Judge D. P., Dietz H. C.
RT Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
RL Science 332:358-361 (2011).
RN [14]; RE0071644.
RX PUBMED: 21493863.
RA Habashi J. P., Doyle J. J., Holm T. M., Aziz H., Schoenhoff F., Bedja D., Chen Y., Modiri A. N., Judge D. P., Dietz H. C.
RT Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
RL Science 332:361-365 (2011).
RN [15]; RE0071947.
RX PUBMED: 21454615.
RA Hong M., Wilkes M. C., Penheiter S. G., Gupta S. K., Edens M., Leof E. B.
RT Non-Smad transforming growth factor-beta signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.
RL J. Biol. Chem. 286:17841-17850 (2011).
RN [16]; RE0072631.
RX PUBMED: 18669633.
RA Ding Q., Gladson C. L., Wu H., Hayasaka H., Olman M. A.
RT Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner.
RL J. Biol. Chem. 283:26839-26849 (2008).
RN [17]; RE0072946.
RX PUBMED: 21858106.
RA Moltzer E., te Riet L., Swagemakers S. M., van Heijningen P. M., Vermeij M., van Veghel R., Bouhuizen A. M., van Esch J. H., Lankhorst S., Ramnath N. W., de Waard M. C., Duncker D. J., van der Spek P. J., Rouwet E. V., Danser A. H., Essers J.
RT Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.
RL PLoS ONE 6:e23411 (2011).
RN [18]; RE0072995.
RX PUBMED: 17293478.
RA Hanada K., Vermeij M., Garinis G. A., de Waard M. C., Kunen M. G., Myers L., Maas A., Duncker D. J., Meijers C., Dietz H. C., Kanaar R., Essers J.
RT Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice.
RL Circ. Res. 100:738-746 (2007).
RN [19]; RE0073043.
RX PUBMED: 22203668.
RA Cabello-Verrugio C., Santander C., Cofre C., Acuna M. J., Melo F., Brandan E.
RT The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-beta-dependent Signaling, and Inhibits TGF-beta-dependent Fibrotic Response in Skeletal Muscles.
RL J. Biol. Chem. 287:6773-6787 (2012).
RN [20]; RE0073082.
RX PUBMED: 18337748.
RA Rudini N., Felici A., Giampietro C., Lampugnani M., Corada M., Swirsding K., Garre M., Liebner S., Letarte M., ten Dijke P., Dejana E.
RT VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
RL EMBO J. 27:993-1004 (2008).
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