AC T02235
XX
ID T02235
XX
DT 27.10.1997 (created); ili.
DT 09.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA PEBP2alphaB1
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SY AML1; AML1b; CBFA2; CCAAT Binding Factor alpha2; PEBP2alphaB.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005053 Runx1.
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CL C0029; runt; 6.4.1.0.2.2.
XX
SZ 451 AA; 48.6 kDa (cDNA) (calc.).
XX
SQ MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGPALASKLRSGDRSMVEVLADHPG
SQ ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
SQ TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR
SQ QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM
SQ QDARQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDL
SQ TAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGS
SQ SQAQAGPFQTGSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPS
SQ QSDVVETEGSHSNSPTNMPPARLEEAVWRPY
XX
SC Swiss-Prot#Q03347-1
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FT 48 182 
PF00853; Runt domain.
FT 50 178 
PS51062; RUNT.
FT 66 437 
PF00478; IMP dehydrogenase / GMP reductase domain.
XX
SF sequence necessary for DNA-binding and splice variants: PEBP2alphaB2 T02241, in which R178 is replaced by N and AA 179-242 are missed [1];
SF association with PEBP2beta subunit protein is with in the runt domain [1];
SF enhanced transcription is mediated by the C-terminus [1];
SF runt domain comprise predominantly beta-strands [2];
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EX skeleton of forelimb,,,Theiler Stage 26; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX skeleton of hindlimb,,,Theiler Stage 26; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
XX
FF Binding of Runx1 to the promoter region of INK4b is disrupted by chimeric protein CBFbeta-SMMHC [4];
FF activator;
FF associates with PEBP2beta protein to form a heterodimer [1];
FF binds to PEBP2 site [1];
FF stimulates transcription through PEBP2 site about 40-fold [1];
XX
IN T27820 BAF57; mouse, Mus musculus.
IN T16150 BRG1; mouse, Mus musculus.
IN T16138 DEC1; Mammalia.
IN T10058 Fli-1; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T01302 GATA-2; mouse, Mus musculus.
IN T02259 PEBP2beta-isoform1; human, Homo sapiens.
IN T01065 PEBP2beta-isoform2; mouse, Mus musculus.
IN T01064 PEBP2beta; mouse, Mus musculus.
IN T06379 PML; mouse, Mus musculus.
IN T25617 sin3a; mouse, Mus musculus.
IN T04273 Smad2; mouse, Mus musculus.
IN T16151 Tal-1; mouse, Mus musculus.
XX
MX M00271 V$AML1_01.
MX M01658 V$AML1_Q4.
MX M07242 V$AML1_Q4_01.
MX M08865 V$AML1_Q4_02.
MX M02084 V$AML1_Q5.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
XX
BS R04444.
BS R29095.
BS R73946.
BS R01140.
BS R73963.
BS R04644.
BS R73956.
BS R01222.
XX
DR TRANSPATH: MO000026245.
DR TRANSCOMPEL: C00173.
DR TRANSCOMPEL: C00184.
DR TRANSCOMPEL: C00185.
DR TRANSCOMPEL: C00196.
DR EMBL: D13802;
DR UniProtKB: Q03347-1;
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RN [1]; RE0006065.
RX PUBMED: 8164679.
RA Bae S., Ogawa E., Maruyama M., Oka H., Satake M., Shigesada K., Jenkins N. A., Gilbert D. J., Copelands N. G., Ito Y.
RT PEBP2alphaB / mouse AML1 consists of multiple isoforms that possess differential transactivation potentials
RL Mol. Biol. Cell 14:3242-3252 (1994).
RN [2]; RE0006077.
RX PUBMED: 8824275.
RA Crute B. E., Lewis A. F., Wu Z., Bushweller J. H., Speck N. A.
RT Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain
RL J. Biol. Chem. 271:26251-26260 (1996).
RN [3]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
RN [4]; RE0052106.
RX PUBMED: 17283131.
RA Markus J., Garin M. T., Bies J., Galili N., Raza A., Thirman M. J., Le Beau M. M., Rowley J. D., Liu P. P., Wolff L.
RT Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).
RL Cancer Res. 67:992-1000 (2007).
RN [5]; RE0070227.
RX PUBMED: 21057086.
RA Miyazaki K., Miyazaki M., Guo Y., Yamasaki N., Kanno M., Honda Z., Oda H., Kawamoto H., Honda H.
RT The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.
RL J. Immunol. 185:7330-7339 (2010).
RN [6]; RE0035530.
RX PUBMED: 9794229.
RA Sato M., Morii E., Komori T., Kawahata H., Sugimoto M., Terai K., Shimizu H., Yasui T., Ogihara H., Yasui N., Ochi T., Kitamura Y., Ito Y., Nomura S.
RT Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues.
RL Oncogene 17:1517-1525 (1998).
XX
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