AC T02241
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ID T02241
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DT 27.10.1997 (created); ili.
DT 30.04.2013 (updated); prb.
CO Copyright (C), QIAGEN.
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FA PEBP2alphaB2
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SY AML1; CBFA2; PEBP2alphaB.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005053 Runx1.
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CL C0029; runt.
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SZ 387 AA; 41.3 kDa (cDNA) (calc.).
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SQ MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGPALASKLRSGDRSMVEVLADHPG
SQ ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA
SQ TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNAR
SQ QIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFG
SQ DPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQ
SQ AGPFQTGSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDV
SQ VETEGSHSNSPTNMPPARLEEAVWRPY
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SC translated from EMBL #D26532
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FT 48 182 
PF00853; Runt domain.
FT 50 178 
PS51062; RUNT.
FT 66 373 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 260 289 
putative nuclear matrix targeting signal [4].
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SF splice variant: PEBP2alphaB1 T02235, in which N178 is replaced by R and contains an insertion of 64 AA at position 179 [1];
SF similar to chicken factor T02253 [3];
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CP T lymphocytes [2].
EX skeleton of forelimb,,,Theiler Stage 26; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [5].
EX skeleton of hindlimb,,,Theiler Stage 26; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [5].
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FF activator;
FF less active than PEBP2alphaB1, but binds to DNA two to three times more strongly [1];
FF binds to DNA through PEBP2 site [1];
FF expression is tissue type dependent [2];
FF believed to be involved in T-cell-specific gene expression [2];
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IN T01065 PEBP2beta-isoform2; mouse, Mus musculus.
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MX M00271 V$AML1_01.
MX M01658 V$AML1_Q4.
MX M07242 V$AML1_Q4_01.
MX M08865 V$AML1_Q4_02.
MX M02084 V$AML1_Q5.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
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BS R01222.
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DR TRANSPATH: MO000026249.
DR EMBL: D26532;
DR UniProtKB: Q03347-2;
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RN [1]; RE0006065.
RX PUBMED: 8164679.
RA Bae S., Ogawa E., Maruyama M., Oka H., Satake M., Shigesada K., Jenkins N. A., Gilbert D. J., Copelands N. G., Ito Y.
RT PEBP2alphaB / mouse AML1 consists of multiple isoforms that possess differential transactivation potentials
RL Mol. Biol. Cell 14:3242-3252 (1994).
RN [2]; RE0006071.
RX PUBMED: 7862157.
RA Satake M., Nomura S., Yamaguchi-Iwai Y., Takahama Y., Hashimoto Y., Niki M., Kitamura Y., Ito Y.
RT Expression of the Runt domain-encoding PEBP2alpha genes in T cells during thymic development
RL Mol. Cell. Biol. 15:1662-1670 (1995).
RN [3]; RE0006085.
RX PUBMED: 8601397.
RA Castagnola P., Gennari M., Gaggero A., Rossi F., Daga A., Corsetti M. T., Calabi F., Cancedda R.
RT Expression of runtB is modulated during chondrocyte differentiation
RL Exp. Cell Res. 223:215-226 (1996).
RN [4]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
RN [5]; RE0035530.
RX PUBMED: 9794229.
RA Sato M., Morii E., Komori T., Kawahata H., Sugimoto M., Terai K., Shimizu H., Yasui T., Ogihara H., Yasui N., Ochi T., Kitamura Y., Ito Y., Nomura S.
RT Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues.
RL Oncogene 17:1517-1525 (1998).
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