AC T01302
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ID T01302
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DT 21.10.1994 (created); ewi.
DT 13.08.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA GATA-2
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SY GATA-2; NF-E1b (chick).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005726 Gata2.
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CL C0004; CC; 2.2.1.1.2.
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SF all sequences outside the C-terminal zinc finger are partially dispensable for megakaryocytic differentiation [3];
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CP pluripotent hematopoietic stem cells [5].
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FF GATA-2 knock-out mice die by embryonic days 10-11 due to defects in hematopoiesis [6];
FF GATA-2 induces megakaryocytic differentiation [3];
FF GATA-2-transfected embryonal stem cells do not express the surface receptors c-kit, flt-3 and CD34 (in contrast to c-Myb-transfected ones T00138) [4];
FF c-Myb T00138 and GATA-2 act independently of each other on hematopoiesis [4];
FF IL-3 stimulation of hematopoietic progenitor cells (BA/F3 0752) leads to MAP kinase-dependent hyper-phosphorylation of GATA-2 [2];
FF cooperates with PU.1 to provide mast cell differentiation [8];
FF regulator of the vascular development, together with SCL/Tal-1 and Ets factors [9];
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IN T08464 C/EBPalpha; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T02235 PEBP2alphaB1; mouse, Mus musculus.
IN T01516 Pit-1B; rat, Rattus norvegicus.
IN T09976 PU.1; human, Homo sapiens.
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MX M00076 V$GATA2_01.
MX M00348 V$GATA2_02.
MX M00349 V$GATA2_03.
MX M01877 V$GATA2_Q5.
MX M00203 V$GATA_C.
MX M00789 V$GATA_Q6.
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BS R71266.
BS R73536.
BS R71577.
BS R71478.
BS R71479.
BS R71480.
BS R71481.
BS R71482.
BS R33239.
BS R14469.
BS R69239.
BS R03884.
BS R21046.
BS R71259.
BS R23089.
BS R23092.
BS R14425.
BS R20583.
BS R59415.
BS R37952.
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DR TRANSPATH: MO000025566.
DR TRANSCOMPEL: C00519.
DR TRANSCOMPEL: C00603.
DR UniProtKB: O09100;
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RN [1]; RE0001072.
RX PUBMED: 1744088.
RA Zon L. I., Gurish M. F., Stevens R. L., Mather C., Reynolds D. S., Austen K. F., Orkin S. H.
RT GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene
RL J. Biol. Chem. 266:22948-22953 (1991).
RN [2]; RE0011615.
RX PUBMED: 7876160.
RA Towatari M., May G. E., Marais R., Perkins G. R., Marshall C. J., Cowles S., Enver T.
RT Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3
RL J. Biol. Chem. 270:4101-4107 (1995).
RN [3]; RE0013447.
RX PUBMED: 7823932.
RA Visvader J. E., Crossley M., Hill J., Orkin S. H., Adams J. M.
RT The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.
RL Mol. Cell. Biol. 15:634-641 (1995).
RN [4]; RE0013449.
RX PUBMED: 8643572.
RA Melotti P., Calabretta B.
RT The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis.
RL Proc. Natl. Acad. Sci. USA 93:5313-5318 (1996).
RN [5]; RE0013450.
RX PUBMED: 7538677.
RA Orlic D., Anderson S., Biesecker L. G., Sorrentino B. P., Bodine D. M.
RT Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.
RL Proc. Natl. Acad. Sci. USA 92:4601-4605 (1995).
RN [6]; RE0013451.
RX PUBMED: 8078582.
RA Tsai F.-Y., Keller G., Kuo F. C., Weiss M., Chen J., Rosenblatt M., Alt F. W., Orkin S. H.
RT An early haematopoietic defect in mice lacking the transcription factor GATA-2.
RL Nature 371:221-226 (1994).
RN [7]; RE0013568.
RX PUBMED: 9452491.
RA Minegishi N., Ohta J., Suwabe N., Nakauchi H., Ishihara H., Hayashi N., Yamamoto M.
RT Alternative promoters regulate transcription of the mouse GATA-2 gene.
RL J. Biol. Chem. 273:3625-3634 (1998).
RN [8]; RE0023175.
RX PUBMED: 12433372.
RA Walsh J. C., DeKoter R. P., Lee H.- J., Smith E. D., Lancki D. W., Gurish M. F., Friend D. S., Stevens R. L., Anastasi J., Singh H.
RT Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.
RL Immunity 17:665-676 (2002).
RN [9]; RE0023734.
RX PUBMED: 11049987.
RA Kappel A., Schlaeger T. M., Flamme I., Orkin S. H., Risau W., Breier G.
RT Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.
RL Blood 96:3078-3085 (2000).
RN [10]; RE0036169.
RX PUBMED: 15632071.
RA Tong Q., Tsai J., Tan G., Dalgin G., Hotamisligil G. S.
RT Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.
RL Mol. Cell. Biol. 25:706-715 (2005).
RN [11]; RE0048127.
RX PUBMED: 10411939.
RA Zhang P., Behre G., Pan J., Iwama A., Wara-Aswapati N., Radomska H. S., Auron P. E., Tenen D. G., Sun Z.
RT Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
RL Proc. Natl. Acad. Sci. USA 96:8705-8710 (1999).
RN [12]; RE0068516.
RX PUBMED: 20833840.
RA Maeda K., Nishiyama C., Ogawa H., Okumura K.
RT GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
RL J. Immunol. 185:4252-4260 (2010).
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