AC T00138
XX
ID T00138
XX
DT 15.10.1992 (created); ewi.
DT 22.09.2014 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA c-Myb
XX
SY c-Myb; MYB; MYB PROTO-ONCOGENE PROTEIN.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G000488 Myb.
XX
CL C0022; trp; 3.5.1.1.1.
XX
SF NMR with third repeat: three alpha-helices, helix 2 and 3 forming a helix-turn-helix motif [27] [6];
SF the turn is 1 AA longer than in the homeo domain or in prokaryotic repressors [27];
SF helix 1 and 2 are nearly parallel, helix 3 nearly perpendicular [27];
SF hydrophobic core of conserved tryptophanes and histidine residues 159 and 184 [27];
SF within the ideal recognition sequence AACTGAC, helix 3 of repeat 3 contacts AAC, helix 3 of repeat 2 GAC, both through the major groove [27];
SF repeat 1 contributes to the overall stability [30];
SF slightly acidic trans-activation domain [13];
SF inhibitory C-terminal domain, acting in is and in trans [13];
SF inhibition involves the leucine zipper [19] [14];
XX
CP pluripotent hematopoietic stem cells [33].
XX
FF regulation of transcription of c-myb gene involves premature termination within the first intron [12];
FF transcriptional activator [25] [7] [9];
FF product of a proto-oncogene involved in hemopoiesis, growth regulation and differentiation;
FF c-Myb-transfected embryonal stem cells express the surface receptors c-kit, flt-3 and CD34 (in contrast to GATA-2-transfected ones T01302) [32];
FF c-Myb and GATA-2 T01302 act independently of each other on hematopoiesis [32];
XX
IN T00138 c-Myb; mouse, Mus musculus.
IN T01318 CBP; mouse, Mus musculus.
IN T01649 HES-1; mouse, Mus musculus.
XX
MX M00004 V$CMYB_01.
MX M01821 V$CMYB_Q5.
MX M02883 V$MYB_03.
MX M02779 V$MYB_05.
MX M07219 V$MYB_07.
MX M00773 V$MYB_Q3.
MX M07299 V$MYB_Q4.
MX M00913 V$MYB_Q5_01.
MX M08890 V$MYB_Q5_02.
MX M00183 V$MYB_Q6.
XX
BS R02603.
BS R02604.
BS R04922.
BS R73933.
BS R73867.
BS R15378.
BS R15415.
BS R62847.
BS R64062.
BS R73948.
BS R58365.
BS R31093.
BS R31095.
BS R38136.
BS R73986.
BS R58919.
BS R42392.
BS R02206.
BS R03185.
BS R73950.
BS R01847.
BS R01848.
XX
DR TRANSPATH: MO000009620.
DR TRANSCOMPEL: C00003.
DR TRANSCOMPEL: C00135.
DR TRANSCOMPEL: C00176.
DR TRANSCOMPEL: C00181.
DR TRANSCOMPEL: C00229.
DR TRANSCOMPEL: C00230.
DR TRANSCOMPEL: C00246.
DR UniProtKB: P06876;
DR PDB: 1IDY.
DR PDB: 1IDZ.
DR PDB: 1MBE.
DR PDB: 1MBF.
DR PDB: 1MBG.
DR PDB: 1MBH.
DR PDB: 1MBJ.
DR PDB: 1MBK.
DR PDB: 1MSE.
DR PDB: 1MSF.
XX
RN [1]; RE0000112.
RX PUBMED: 2688896.
RA Ness S. A., Marknell A., Graf T.
RT The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
RL Cell 59:1115-1125 (1989).
RN [2]; RE0000202.
RX PUBMED: 1709592.
RA Mucenski M. L., McLain K., Kier A. B., Swerdlow S. H., Schreiner C. M., Miller Th. A., Pietryga D. W., Scott jr W. J., Potter S. S.
RT A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
RL Cell 65:677-689 (1991).
RN [3]; RE0000435.
RX PUBMED: 2403925.
RA Howe K. M., Reakes C. F. L., Watson R. J.
RT Characterization of the sequence-specific interaction of mouse c-myb protein with DNA
RL EMBO J. 9:161-169 (1990).
RN [4]; RE0000580.
RX PUBMED: 2037048.
RA Carr M. D., Mott R. F.
RT The transcriptional control proteins c-Myb and v-Myb contain a basic region DNA binding motif
RL FEBS Lett. 282:293-294 (1991).
RN [5]; RE0000684.
RX PUBMED: 2279697.
RA Luescher B., Eisenman R. N.
RT New light on Myc and Myb. part II. Myb
RL Genes Dev. 4:2235-2241 (1990).
RN [6]; RE0000931.
RX PUBMED: 2246275.
RA Kanei-Ishii Ch., Sarai A., Sawazaki T., Nakagoshi H., He D.-N., Ogata K., Nishimura Y., Ishii Sh.
RT The Tryptophan cluster: A hypothetical structure of the DNA-binding domain of the myb protooncogene product
RL J. Biol. Chem. 265:19990-19995 (1990).
RN [7]; RE0000977.
RX PUBMED: 2154480.
RA Nakagoshi H., Nagase T., Kanei-Ishii C., Ueno Y., Ishii S.
RT Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription
RL J. Biol. Chem. 265:3479-3483 (1990).
RN [8]; RE0001185.
RX PUBMED: 1727489.
RA Dasgupta P., Reddy C. D., Saikumar P., Reddy E. P.
RT The cellular proto-oncogene product Myb acts as transcriptional activator of the long terminal repeat of human T-lymphotropic virus type I
RL J. Virol. 66:270-276 (1992).
RN [9]; RE0001835.
RX PUBMED: 3185713.
RA Biedenkapp H., Borgmeyer U., Sippel A., Klempnauer K.-H.
RT Viral myb oncogene encodes a sequence-specific DNA-binding activity
RL Nature 335:835-837 (1988).
RN [10]; RE0002147.
RX PUBMED: 1861984.
RA Howe K. M., Watson R. J.
RT Nucleotide preferences in sequence-specific recognition of DNA by c-myb protein
RL Nucleic Acids Res. 19:3913-3919 (1991).
RN [11]; RE0002238.
RX PUBMED: 1992438.
RA Punyammalee B., Crabell M., de Lannoy C., Perbal B., Glansdorff N.
RT Two c-myb proteins differing by their aminotermini exhibit different transcriptional transactivation activities
RL Oncogene 6:11-19 (1991).
RN [12]; RE0002379.
RX PUBMED: 2678098.
RA Reddy C. D., Reddy E. P.
RT Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression
RL Proc. Natl. Acad. Sci. USA 86:7326-7330 (1989).
RN [13]; RE0002390.
RX PUBMED: 2668947.
RA Sakura H., Kanei-Ishii C., Nagase T., Nakagoshi H., Gonda T. J.
RT Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene
RL Proc. Natl. Acad. Sci. USA 86:5758-5762 (1989).
RN [14]; RE0002433.
RX PUBMED: 1557416.
RA Kanei-Ishii C., MacMillan E. M., Nomura T., Sarai A., Ramsay R. G., Aimoto S., Ishii S., Gonda Th. J.
RT Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure
RL Proc. Natl. Acad. Sci. USA 89:3088-3092 (1992).
RN [15]; RE0002435.
RX PUBMED: 2236054.
RA Saikumar P., Murali R., Reddy E. P.
RT Role of tryptophan repeats and flanking amino acids in Myb-DNA interaction
RL Proc. Natl. Acad. Sci. USA 87:8452-8456 (1990).
RN [16]; RE0002437.
RX PUBMED: 1741383.
RA Dudek H., Tantravahi R. V., Rao V. N., Reddy E. Sh., Reddy E. P.
RT Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter
RL Proc. Natl. Acad. Sci. USA 89:1291-1295 (1992).
RN [17]; RE0002669.
RX PUBMED: 2665077.
RA Gewirtz A. M., Anfossi G., Venturelli D., Valpreda S., Sims R., Calabretta B.
RT G1/S Transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb
RL Science 245:180-183 (1989).
RN [18]; RE0003209.
RX PUBMED: 1347906.
RA Siu G., Wurster A. L., Lipsick J. S., Hedrick S. M.
RT Expression of the CD4 gene requires a Myb transcription factor
RL Mol. Cell. Biol. 12:1592-1604 (1992).
RN [19]; RE0003488.
RX PUBMED: 8408047.
RA Nomura T., Sakai N., Sarai A., Sudo T., Kanei-Ishii C., Ramsay R. G., Favier D., Gonda T. J., Ishii S.
RT Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper
RL J. Biol. Chem. 268:21914-21923 (1993).
RN [20]; RE0003555.
RX PUBMED: 3016644.
RA Lavu S., Reddy E. P.
RT Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences
RL Nucleic Acids Res. 14:5309-5320 (1986).
RN [21]; RE0003556.
RX PUBMED: 3010282.
RA Bender T. P., Kuehl W. M.
RT Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogenity
RL Proc. Natl. Acad. Sci. USA 83:3204-3208 (1986).
RN [22]; RE0003557.
RX PUBMED: 3608990.
RA Watson R. J., Dyson P. J., McMahon J.
RT Multiple c-myb transcript cap sites are variously utilized in cells of mouse haemopoietic origin
RL EMBO J. 6:1643-1651 (1987).
RN [23]; RE0003558.
RX PUBMED: 2481264.
RA Sobieszczuk P. W., Gonda T. J., Dunn A. R.
RT Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene
RL Nucleic Acids Res. 17:9593-9611 (1989).
RN [24]; RE0003559.
RX PUBMED: 2998780.
RA Gonda T. J., Gough N. M., Dunn A. R., de Blaquire J.
RT Nucleotide sequence of cDNA clones of the murine myb proto-oncogene
RL EMBO J. 4:2003-2008 (1985).
RN [25]; RE0003560.
RX PUBMED: 2536148.
RA Nishina Y., Nakagoshi H., Imamoto F., Gonda T. J., Ishii S.
RT Trans-activation by the c-myb proto-oncogene
RL Nucleic Acids Res. 17:107-117 (1989).
RN [26]; RE0003562.
RX PUBMED: 2233716.
RA Evans J. L., Moore T. L., Kuehl W. M., Bender T., Ting J. P.-Y.
RT Functional analysis of c-myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myb promoter
RL Mol. Cell. Biol. 10:5747-5752 (1990).
RN [27]; RE0003567.
RX PUBMED: 1631139.
RA Ogata K., Hojo H., Aimoto S., Nakai T., Nakamura H., Sarai A., Ishii S., Nishimura Y.
RT Solution structure of DNA binding unit of myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core
RL Proc. Natl. Acad. Sci. USA 89:6428-6432 (1992).
RN [28]; RE0003568.
RX PUBMED: 2572967.
RA Frampton J., Leutz A., Gibson T., Graf T.
RT DNA-binding domain ancestry
RL Nature 342:134-134 (1989).
RN [29]; RE0003571.
RX PUBMED: 8365401.
RA Jamin N., Gabrielsen O. S., Gilles N., Toma F.
RT Secondary structure of the DNA-binding domain of the c-myb oncoprotein in solution. A multidimensional double and triple heteronuclear NMR study.
RL Eur. J. Biochem. 216:147-154 (1993).
RN [30]; RE0003575.
RX PUBMED: 8415700.
RA Tanikawa J., Yasukawa T., Enari M., Ogata K., Nishimura Y., Ishii S., Sarai A.
RT Recognition of specific DNA sequences by the c-myb protooncogene product: role of the three repeat units in the DNA-binding domain
RL Proc. Natl. Acad. Sci. USA 90:9320-9324 (1993).
RN [31]; RE0011121.
RX PUBMED: 7604007.
RA Aziz N., Miglarese M. R., Hendrickson R. C., Shabanowitz J., Sturgill T. W., Hunt D. F., Bender T. P.
RT Modulation of c-Myb-induced transcription activation by a phophorylation site near the negative regulatory domain
RL Proc. Natl. Acad. Sci. USA 92:6429-6433 (1995).
RN [32]; RE0013449.
RX PUBMED: 8643572.
RA Melotti P., Calabretta B.
RT The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis.
RL Proc. Natl. Acad. Sci. USA 93:5313-5318 (1996).
RN [33]; RE0013450.
RX PUBMED: 7538677.
RA Orlic D., Anderson S., Biesecker L. G., Sorrentino B. P., Bodine D. M.
RT Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.
RL Proc. Natl. Acad. Sci. USA 92:4601-4605 (1995).
RN [34]; RE0019332.
RX PUBMED: 2670562.
RA GONDA T.J., BUCKMASTER C., RAMSAY R.G.
RT Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.
RL EMBO J. 8:1777-1783 (1989).
RN [35]; RE0019366.
RX PUBMED: 3023843.
RA SHEN-ONG G.L.C., MORSE H.C. III POTTER M., MUSHINSKI F.
RT Two modes of c-myb activation in virus-induced mouse myeloid tumors.
RL Mol. Cell. Biol. 6:380-392 (1986).
RN [36]; RE0019367.
RX PUBMED: 3033638.
RA ROSSON D., DUGAN D., REDDY E.P.
RT Aberrant splicing events that are induced by proviral integration: implications for myb oncogene activation.
RL Proc. Natl. Acad. Sci. USA 84:3171-3175 (1987).
RN [37]; RE0019368.
RX PUBMED: 8942977.
RA FURUKAWA K., ODA M., NAKAMURA H.
RT A small engineered protein lacks structural uniqueness by increasing the side-chain conformational entropy.
RL Proc. Natl. Acad. Sci. USA 93:13583-13588 (1996).
RN [38]; RE0019369.
RX PUBMED: 7796266.
RA OGATA K., MORIKAWA S., NAKAMURA H., HOJO H., YOSHIMURA S., ZHANG R., AIMOTO S., AMETANI Y., HIRATA Z., SARAI A., ISHII S., NISHIMURA Y.
RT Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.
RL Nat. Struct. Biol. 2:309-320 (1995).
RN [39]; RE0019370.
RX PUBMED: 1923521.
RA HU Y., RAMSAY R.G., KANEI-ISHII C., ISHII S., GONDA T.J.
RT Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain.
RL Oncogene 6:1549-1553 (1991).
RN [40]; RE0019371.
RX PUBMED: 3014527.
RA WEINSTEIN Y., IHLE J.N., LAVU S., REDDY P.E.
RT Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line.
RL Proc. Natl. Acad. Sci. USA 83:5010-5014 (1986).
RN [41]; RE0025599.
RX PUBMED: 9447996.
RA Tavner F. J., Simpson R., Tashiro S., Favier D., Jenkins N. A., Gilbert D. J., Copeland N. G., MacMillan E. M., Lutwyche J., Keough R. A., Ishii S., Gonda T. J.
RT Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.
RL Mol. Cell. Biol. 18:989-1002 (1998).
XX
//