
AC   T08464
XX
ID   T08464
XX
DT   23.01.2006 (created); jag.
DT   15.04.2016 (updated); hna.
CO   Copyright (C), QIAGEN.
XX
FA   C/EBPalpha
XX
SY   BPc; C/EBP; C/EBP alpha; C/EBPalpha; C/EBPalpha(p42); CBP; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein alpha; CEBPA; EBP20; p42(C/EBPalpha); p42C/EBPalpha.
XX
OS   mouse, Mus musculus
OC   eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE   G000490 Cebpa.
XX
CL   C0008; bZIP; 1.1.8.1.1.
XX
FF   The affinity of C/EBPalpha binding to Nupr1 G042247 promoter is higher than C/EBPbeta [5];
XX
IN   T08464 C/EBPalpha; mouse, Mus musculus.
IN   T04203 FOXO1A; mouse, Mus musculus.
IN   T01302 GATA-2; mouse, Mus musculus.
IN   T16993 MIBP1; mouse, Mus musculus.
IN   T08563 NF-YA; Mammalia.
IN   T22189 RECC1; mouse, Mus musculus.
IN   T10505 TTF-1; Mammalia.
XX
MX   M00116 V$CEBPA_01.
MX   M07412 V$CEBPA_04.
MX   M07037 V$CEBPA_Q4.
MX   M01866 V$CEBPA_Q6.
MX   M00159 V$CEBP_01.
MX   M00201 V$CEBP_C.
MX   M00190 V$CEBP_Q2.
MX   M00912 V$CEBP_Q2_01.
MX   M00770 V$CEBP_Q3.
MX   M00249 V$CHOP_01.
XX
BS   R39946.
BS   R57365.
BS   R57366.
BS   R32278.
BS   R36013.
BS   R38277.
BS   R20520.
BS   R29866.
BS   R29867.
BS   R29868.
BS   R23180.
BS   R37773.
BS   R20524.
BS   R31971.
BS   R39907.
BS   R39908.
BS   R42260.
BS   R42264.
BS   R32324.
BS   R60521.
BS   R20625.
BS   R41835.
BS   R03135.
BS   R28460.
BS   R28369.
BS   R28370.
BS   R61577.
BS   R37804.
BS   R37806.
BS   R62515.
BS   R73123.
BS   R64373.
BS   R33469.
BS   R62523.
BS   R62525.
BS   R37049.
BS   R67676.
BS   R67677.
BS   R23524.
BS   R36284.
BS   R26887.
BS   R20515.
BS   R26872.
BS   R21754.
BS   R66204.
BS   R29474.
BS   R62741.
BS   R62742.
BS   R67929.
BS   R67930.
BS   R33702.
BS   R33703.
BS   R33709.
BS   R33705.
BS   R23087.
BS   R64700.
BS   R63925.
BS   R66205.
BS   R66209.
BS   R39451.
BS   R64245.
BS   R72787.
BS   R72788.
BS   R67816.
BS   R60860.
BS   R21609.
BS   R00097.
BS   R34581.
XX
DR   TRANSPATH: MO000058349.
DR   TRANSCOMPEL: C00456.
DR   TRANSCOMPEL: C00585.
DR   UniProtKB: P53566;
XX
RN   [1]; RE0025710.
RX   PUBMED: 11867521.
RA   Wang H., Goode T., Iakova P., Albrecht J. H., Timchenko N. A.
RT   C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.
RL   EMBO J. 21:930-41 (2002).
RN   [2]; RE0032033.
RX   PUBMED: 12757710.
RA   Iakova P., Awad S. S., Timchenko N. A.
RT   Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.
RL   Cell 113:495-506 (2003).
RN   [3]; RE0035887.
RX   PUBMED: 14701740.
RA   Ross S. E., Radomska H. S., Wu B., Zhang P., Winnay J. N., Bajnok L., Wright W. S., Schaufele F., Tenen D. G., MacDougald O. A.
RT   Phosphorylation of C/EBPalpha inhibits granulopoiesis.
RL   Mol. Cell. Biol. 24:675-686 (2004).
RN   [4]; RE0036169.
RX   PUBMED: 15632071.
RA   Tong Q., Tsai J., Tan G., Dalgin G., Hotamisligil G. S.
RT   Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.
RL   Mol. Cell. Biol. 25:706-715 (2005).
RN   [5]; RE0041442.
RX   PUBMED: 10510303.
RA   Vasseur S., Mallo G. V., Garcia-Montero A., Ortiz E. M., Fiedler F., Canepa E., Moreno S., Iovanna J. L.
RT   Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter
RL   Biochem. J. 343:377-83 (1999).
RN   [6]; RE0042688.
RX   PUBMED: 11684017.
RA   Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A.
RT   C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
RL   Mol. Cell 8:817-28 (2001).
RN   [7]; RE0047660.
RX   PUBMED: 12727880.
RA   Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J.
RT   Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.
RL   EMBO J. 22:2135-2145 (2003).
RN   [8]; RE0048262.
RX   PUBMED: 16210377.
RA   Singh R., Artaza J. N., Taylor W. E., Braga M., Yuan X., Gonzalez-Cadavid N. F., Bhasin S.
RT   Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors.
RL   Endocrinology 147:141-154 (2006).
RN   [9]; RE0048349.
RX   PUBMED: 11356826.
RA   Hong S., Park S. J., Kong H. J., Shuman J. D., Cheong J.
RT   Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells.
RL   J. Biol. Chem. 276:28098-28105 (2001).
RN   [10]; RE0048488.
RX   PUBMED: 15691842.
RA   Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT   The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL   J. Biol. Chem. 280:13600-13605 (2005).
RN   [11]; RE0048515.
RX   PUBMED: 16644732.
RA   McFie P. J., Wang G. L., Timchenko N. A., Wilson H. L., Hu X., Roesler W. J.
RT   Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.
RL   J. Biol. Chem. 281:18069-18080 (2006).
RN   [12]; RE0048532.
RX   PUBMED: 16595692.
RA   Xu Y., Zhou Y. L., Luo W., Zhu Q. S., Levy D., MacDougald O. A., Snead M. l.
RT   NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene.
RL   J. Biol. Chem. 281:16090-16098 (2006).
RN   [13]; RE0050196.
RX   PUBMED: 15987634.
RA   Bouaboula M., Hilairet S., Marchand J., Fajas L., Le Fur G., Casellas P.
RT   Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation.
RL   Eur. J. Pharmacol. 517:174-181 (2005).
RN   [14]; RE0053554.
RX   PUBMED: 16807249.
RA   Qiao L., MacDougald O. A., Shao J.
RT   CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.
RL   J. Biol. Chem. 281:24390-24397 (2006).
RN   [15]; RE0065384.
RX   PUBMED: 15930175.
RA   Hogan J. C., Stephens J. M.
RT   Effects of leukemia inhibitory factor on 3T3-L1 adipocytes.
RL   J. Endocrinol. 185:485-496 (2005).
XX
//