AC T04203
XX
ID T04203
XX
DT 19.01.2001 (created); rio.
DT 11.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA FOXO1A
XX
SY FKHR.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002641 Foxo1.
XX
CL C0023; fork head; 3.3.1.15.1.
XX
SF 91% amino acid identity to human FOXO1A T02936, 100% identity within the fork head domain [2];
XX
CP (E15.5:) adipose tissue, (adult:) highest levels in ovaries and uterus, kidney, skeletal muscle, brown and white adipose tissue, spleen, liver [2] [3]; expression began to increase after 6h of food deprivation, had a peak between 12h and 24h, and returned to the basal level by 24h of refeeding [20].
XX
IN T08464 C/EBPalpha; mouse, Mus musculus.
IN T08261 CAR; mouse, Mus musculus.
IN T05252 HDAC5; human, Homo sapiens.
IN T01617 RBPJK; mouse, Mus musculus.
IN T10351 RORgamma; mouse, Mus musculus.
XX
MX M07286 V$FOXO1A_Q3.
MX M03823 V$FOXO1A_Q5.
MX M00473 V$FOXO1_01.
MX M00474 V$FOXO1_02.
MX M01968 V$FOXO1_03.
MX M01969 V$FOXO1_04.
MX M07094 V$FOXO1_08.
MX M01216 V$FOXO1_Q5.
XX
BS R09923.
BS R60880.
BS R69976.
BS R38256.
BS R38258.
BS R65104.
BS R26328.
BS R73200.
BS R59738.
BS R59739.
BS R59740.
BS R31044.
BS R24868.
BS R68226.
BS R63102.
BS R65074.
BS R33060.
BS R33061.
BS R33062.
BS R62551.
BS R65102.
BS R65103.
BS R64956.
BS R64958.
BS R64959.
XX
DR TRANSPATH: MO000021888.
DR TRANSCOMPEL: C00518.
DR UniProtKB: Q9R1E0;
XX
RN [1]; RE0015570.
RA Biggs W. H., Cavenee W. K., Arden K. C.
RT Identification and Characterization of Murine Members of the FKHR Subclass of Winged-Helix Transcription Factors
RL direct submission (EMBL) : ().
RN [2]; RE0016820.
RX PUBMED: 11353388.
RA Biggs W. H. 3rd, Cavenee W. K., Arden K. C.
RT Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
RL Mamm. Genome 12:416-425 (2001).
RN [3]; RE0016824.
RX PUBMED: 10880363.
RA Furuyama T., Nakazawa T., Nakano I., Mori N.
RT Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
RL Biochem. J. 349:629-634 (2000).
RN [4]; RE0048304.
RX PUBMED: 15340055.
RA Kodama S., Koike C., Negishi M., Yamamoto Y.
RT Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
RL Mol. Cell. Biol. 24:7931-7940 (2004).
RN [5]; RE0048309.
RX PUBMED: 15668399.
RA Huang H., Regan K. M., Wang F., Wang D., Smith D. I., van Deursen J. M., Tindall D. J.
RT Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
RL Proc. Natl. Acad. Sci. USA 102:1649-1654 (2005).
RN [6]; RE0049748.
RX PUBMED: 16216880.
RA Oriente F., Andreozzi F., Romano C., Perruolo G., Perfetti A., Fiory F., Miele C., Beguinot F., Formisano P.
RT Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.
RL J. Biol. Chem. 280:40642-40649 (2005).
RN [7]; RE0055918.
RX PUBMED: 17717603.
RA Kitamura T., Kitamura Y. I., Funahashi Y., Shawber C. J., Castrillon D. H., Kollipara R., DePinho R. A., Kitajewski J., Accili D.
RT A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
RL J. Clin. Invest. 117:2477-2485 (2007).
RN [8]; RE0055955.
RX PUBMED: 10347145.
RA Nakae J., Park B. C., Accili D.
RT Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.
RL J. Biol. Chem. 274:15982-15985 (1999).
RN [9]; RE0056059.
RX PUBMED: 18356527.
RA Yuan Z., Becker E. B., Merlo P., Yamada T., DiBacco S., Konishi Y., Schaefer E. M., Bonni A.
RT Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
RL Science 319:1665-1668 (2008).
RN [10]; RE0060049.
RX PUBMED: 15817464.
RA Kim S. J., Winter K., Nian C., Tsuneoka M., Koda Y., McIntosh C. H.
RT Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression.
RL J. Biol. Chem. 280:22297-22307 (2005).
RN [11]; RE0060808.
RX PUBMED: 16644730.
RA Rhee S. H., Kim H., Moyer M. P., Pothoulakis C.
RT Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells.
RL J. Biol. Chem. 281:18560-18568 (2006).
RN [12]; RE0063403.
RX PUBMED: 19237543.
RA Shin D. J., Osborne T. F.
RT FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.
RL J. Biol. Chem. 284:11110-11120 (2009).
RN [13]; RE0065655.
RX PUBMED: 19196834.
RA Liu Z., Rudd M. D., Hernandez-Gonzalez I., Gonzalez-Robayna I., Fan H. Y., Zeleznik A. J., Richards J. S.
RT FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells.
RL Mol. Endocrinol. 23:649-661 (2009).
RN [14]; RE0067543.
RX PUBMED: 17015685.
RA Charvet C., Canonigo A. J., Becart S., Maurer U., Miletic A. V., Swat W., Deckert M., Altman A.
RT Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
RL J. Immunol. 177:5024-5031 (2006).
RN [15]; RE0067774.
RX PUBMED: 17077083.
RA Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
RT Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
RL J. Biol. Chem. 281:40242-40251 (2006).
RN [16]; RE0068651.
RX PUBMED: 19696026.
RA Sengupta A., Molkentin J. D., Yutzey K. E.
RT FoxO transcription factors promote autophagy in cardiomyocytes.
RL J. Biol. Chem. 284:28319-28331 (2009).
RN [17]; RE0070024.
RX PUBMED: 19841191.
RA Escribano C., Delgado-Martin C., Rodriguez-Fernandez J. L.
RT CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
RL J. Immunol. 183:6282-6295 (2009).
RN [18]; RE0071224.
RX PUBMED: 21957439.
RA Arndt B., Krieger T., Kalinski T., Thielitz A., Reinhold D., Roessner A., Schraven B., Simeoni L.
RT The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling.
RL PLoS ONE 6:e23761 (2011).
RN [19]; RE0071445.
RX PUBMED: 21148297.
RA Chen X. W., Leto D., Xiong T., Yu G., Cheng A., Decker S., Saltiel A. R.
RT A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action.
RL Mol. Biol. Cell 22:141-152 (2011).
RN [20]; RE0035532.
RX PUBMED: 12820900.
RA Furuyama T., Kitayama K., Yamashita H., Mori N.
RT Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.
RL Biochem. J. 375:365-371 (2003).
XX
//