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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08261 XX ID T08261 XX DT 11.11.2005 (created); oke. DT 27.02.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA CAR XX SY CAR-beta; CAR1; constitutive androstane receptor; constitutively active receptor; MB67 (human); mCAR; mCAR1; NR1I3. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004778 Nr1i3. XX CL C0002; CC (rec). XX SZ 358 AA; 40.9 kDa (cDNA) (calc.). XX SQ MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFA SQ GRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQ SQ KELVQILLGAHTRHVGPLFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQ SQ QIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAV SQ HAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMAL SQ ILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS XX SC translated from EMBL #AF009327 XX FT 18 89 SM00399; c4gold. FT 18 93 PS51030; NUCLEAR_REC_DBD_2. FT 19 94 PF00105; Zinc finger, C4 type (two domains). FT 21 86 DBD [1]. FT 162 190 LBD, helix 3 [2]. FT 171 171 interaction with ligand [2]. FT 173 333 SM00430; holi. FT 174 174 interaction with ligand [2]. FT 176 356 PF00104; Ligand-binding domain of nuclear hormon. FT 317 358 AF-2 [1]. FT 322 329 9th heptad/I box [1]. XX IN T04203 FOXO1A; mouse, Mus musculus. IN T01331 RXR-alpha; mouse, Mus musculus. IN T01332 RXR-beta; mouse, Mus musculus. XX MX M07280 V$NR1NR2_Q3. XX BS R19230. BS R19188. XX DR TRANSPATH: MO000056528. DR EMBL: AF009327; DR UniProtKB: O35627-1; XX RN [1]; RE0013646. RX PUBMED: 9295294. RA Choi H. S., Chung M., Tzameli I., Simha D., Lee Y. K., Seol W., Moore D. D. RT Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR RL J. Biol. Chem. 272:23565-23571 (1997). RN [2]; RE0023337. RX PUBMED: 10757780. RA Tzameli I., Pissios P., Schuetz E. G., Moore D. D. RT The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. RL Mol. Cell. Biol. 20:2951-2958 (2000). RN [3]; RE0048304. RX PUBMED: 15340055. RA Kodama S., Koike C., Negishi M., Yamamoto Y. RT Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. RL Mol. Cell. Biol. 24:7931-7940 (2004). XX //