AC T08261
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ID T08261
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DT 11.11.2005 (created); oke.
DT 27.02.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA CAR
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SY CAR-beta; CAR1; constitutive androstane receptor; constitutively active receptor; MB67 (human); mCAR; mCAR1; NR1I3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004778 Nr1i3.
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CL C0002; CC (rec).
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SZ 358 AA; 40.9 kDa (cDNA) (calc.).
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SQ MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFA
SQ GRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQ
SQ KELVQILLGAHTRHVGPLFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQ
SQ QIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAV
SQ HAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMAL
SQ ILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
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SC translated from EMBL #AF009327
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FT 18 89 
SM00399; c4gold.
FT 18 93 
PS51030; NUCLEAR_REC_DBD_2.
FT 19 94 
PF00105; Zinc finger, C4 type (two domains).
FT 21 86 
DBD [1].
FT 162 190 
LBD, helix 3 [2].
FT 171 171 
interaction with ligand [2].
FT 173 333 
SM00430; holi.
FT 174 174 
interaction with ligand [2].
FT 176 356 
PF00104; Ligand-binding domain of nuclear hormon.
FT 317 358 
AF-2 [1].
FT 322 329 9th heptad/I box [1].
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IN T04203 FOXO1A; mouse, Mus musculus.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01332 RXR-beta; mouse, Mus musculus.
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MX M07280 V$NR1NR2_Q3.
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BS R19230.
BS R19188.
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DR TRANSPATH: MO000056528.
DR EMBL: AF009327;
DR UniProtKB: O35627-1;
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RN [1]; RE0013646.
RX PUBMED: 9295294.
RA Choi H. S., Chung M., Tzameli I., Simha D., Lee Y. K., Seol W., Moore D. D.
RT Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
RL J. Biol. Chem. 272:23565-23571 (1997).
RN [2]; RE0023337.
RX PUBMED: 10757780.
RA Tzameli I., Pissios P., Schuetz E. G., Moore D. D.
RT The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.
RL Mol. Cell. Biol. 20:2951-2958 (2000).
RN [3]; RE0048304.
RX PUBMED: 15340055.
RA Kodama S., Koike C., Negishi M., Yamamoto Y.
RT Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
RL Mol. Cell. Biol. 24:7931-7940 (2004).
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