TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01332 XX ID T01332 XX DT 25.10.1994 (created); ewi. DT 08.12.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA RXR-beta XX SY H2RIIBP; NR2B2; retinoid X receptor beta; RXR-beta. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G008775 Rxrb. XX CL C0002; CC (rec); XX SF 2 mRNA-species (2.8 and 3.4 kb) exist [3]; SF two protein isoforms caused by differential splicing exist with a length of 410 aa and 520 aa; XX CP (embryo:) both isoforms (2.8 kb and 3.4 kb mRNA) expressed on E10.5, E11.5, E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5 [3]; E16.5 (in situ): ubiquitous expression with strong signals in central nervous systems [3] [3]. XX FF natural occurring high affinity ligand (retinoid X) is 9-cis retinoic acid which induces transactivation activity [3]; FF responds to a variety of endogenous retinoids, but again 9-cis retinoic acid is most potent ligand with high transactivation activity (up to 40-fold more active than all-trans retinoic acid) [3]; FF all-trans retinoic acid, which is a low affinity ligand, could serve as a metabolic precursor for a high affinity ligands like 9-cis retinoic acid [3]; FF AF-2 is ligand-inducible and promoter context-dependent; FF modulating function is also promoter context-dependent, but ligand-independent; XX IN T08261 CAR; mouse, Mus musculus. IN T00719 NR1B1-isoform1; human, Homo sapiens. IN T01352 PPARalpha; clawed frog, Xenopus laevis. IN T01330 RAR-gamma1; human, Homo sapiens. IN T00720 RAR-gamma; human, Homo sapiens. IN T01329 RAR-gamma; mouse, Mus musculus. IN T00853 T3R-beta1; rat, Rattus norvegicus. IN T01692 T3R-beta1; chick, Gallus gallus. IN T01693 T3R-beta2; chick, Gallus gallus. IN T00885 VDR; human, Homo sapiens. IN T09401 VDR; mouse, Mus musculus. XX MX M00966 V$DR3_Q4. MX M00965 V$DR4_Q2. MX M07280 V$NR1NR2_Q3. MX M00963 V$T3R_Q6. XX BS R04810. BS R04808. BS R10041. BS R01673. BS R01321. BS R19685. BS R19689. BS R01053. BS R04401. BS R04402. BS R04451. BS R00619. BS R03931. BS R39981. XX DR TRANSPATH: MO000025591. DR UniProtKB: P28704; XX RN [1]; RE0000265. RX PUBMED: 1310259. RA Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewski T., Chen J.-Y., Staub A., Garnier J.-M., Mader S., Chambon P. RT Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently RL Cell 68:377-395 (1992). RN [2]; RE0000270. RX PUBMED: 1326406. RA Nagpal S., Saunders M., Kastner P., Durand B., Nakshatri H., Chambon P. RT Promoter context-and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors RL Cell 70:1007-1019 (1992). RN [3]; RE0000789. RX PUBMED: 1312497. RA Mangelsdorf D. J., Borgmeyer U., Heyman R. A., Zhou J. Y., Ong E. S., Oro A. E., Kakizuka A., Evans R. M. RT Characterization of three RXR genes that mediate the action of 9-cis retinoic acid RL Genes Dev. 6:329-344 (1992). RN [4]; RE0002413. RX PUBMED: 2554307. RA Hamada K., Gleason S., Levi B.-Z., Hirschfeld S., Apella E., Ozato K. RT H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element RL Proc. Natl. Acad. Sci. USA 86:8289-8293 (1989). RN [5]; RE0051983. RX PUBMED: 12529369. RA Barry J. B., Leong G. M., Church W. B., Issa L. L., Eisman J. A., Gardiner E. M. RT Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues. RL J. Biol. Chem. 278:8224-8228 (2003). XX //