AC T01352
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ID T01352
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DT 26.10.1994 (created); ewi.
DT 28.11.2007 (updated); jag.
CO Copyright (C), QIAGEN.
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FA PPARalpha
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SY NR1C1; peroxisome proliferator-activated receptor alpha; PPARalpha.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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CL C0002; CC (rec).
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SZ 474 AA; 52.9 kDa (cDNA) (calc.).
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SQ MSTIMVDTNSELCILTPLDEDDLESPLSGEFLQDIVDIQDITQTIGDDGSTPFGASEHQF
SQ FGNSPGSIGSVSTDLTDTLSPASSPASITFPAASGSAEDAACKSLNLECRVCSDKASGFH
SQ YGVHACEGCKGFFRRTIRLKLVYDRCERMCKIQKKNRNKCQYCRFEKCLNVGMSHNAIRF
SQ GRMPRSEKAKLKAEVLMCDQDVKDSQMADLLSLARLIYDAYLKNFNMNKVKARAILTGKA
SQ SNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSI
SQ PGFTELDLNDQVTLLKYGVYEAMFAMLASVMNKDGMLVAYGNGFITREFLKSLRKPIGDM
SQ MEPKFEFAMKFNALELDDSDLSLFVAALICCGDRPGLVNIPSIEKMQESIVHVLKLHLQS
SQ NHPDDSFLFPKLLQKMADLRQLVTEHAQLVQTIKKTETDAALHPLLQEIYRDMY
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SC Swiss-Prot#P37232
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FT 106 176 
SM00399; c4gold.
FT 106 180 
PS51030; NUCLEAR_REC_DBD_2.
FT 107 181 
PF00105; Zinc finger, C4 type (two domains).
FT 108 173 
DNA-binding domain [2].
FT 161 424 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 279 474 
ligand-binding domain [2].
FT 284 443 
SM00430; holi.
FT 287 469 
PF00104; Ligand-binding domain of nuclear hormon.
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CP ubiquitous; highest level in oocytes and kidney.
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FF control of peroxisomal beta-oxidation pathway;
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IN T01332 RXR-beta; mouse, Mus musculus.
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MX M00242 V$PPARA_01.
MX M00518 V$PPARA_02.
MX M01282 V$PPARA_Q6.
MX M00763 V$PPARDR1_Q2.
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BS R07669.
BS R07670.
BS R07671.
BS R07672.
BS R07673.
BS R07674.
BS R07675.
BS R04600.
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DR TRANSPATH: MO000025608.
DR EMBL: M84161;
DR UniProtKB: P37232; PPARA_XENLA.
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RN [1]; RE0000272.
RX PUBMED: 1312391.
RA Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.
RT Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
RL Cell 68:879-887 (1992).
RN [2]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
RN [3]; RE0049967.
RX PUBMED: 9113987.
RA Kliewer S. A., Sundseth S. S., Jones S. A., Brown P. J., Wisely G. B., Koble C. S., Devchand P., Wahli W., Willson T. M., Lenhard J. M., Lehmann J. M.
RT Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
RL Proc. Natl. Acad. Sci. USA 94:4318-4323 (1997).
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