AC T01617
AS T00440.
XX
ID T01617
XX
DT 26.01.1996 (created); ewi.
DT 30.06.2016 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA RBPJK
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SY C-promoter binding factor 1; CBF1; CSL; IGKJRB; IGKJRB1; RBP-J; RBP-J kappa; RBPJK; RBPSUH; recombination signal-binding protein of Jkappa.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004493 Rbpj.
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HO Su(H) (Drosophila).
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CL C0020; Rel; 6.1.4.1.1.
XX
FF transcriptional repressor [2];
FF binds to the recombination signal for V(D)J rearrangements [5];
FF previously reported binding to V(D)J recombination signal was not observed [2];
FF involved in Notch signaling pathway and in this context activation of Hey2 T05083 [6];
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IN T04203 FOXO1A; mouse, Mus musculus.
IN T17721 Notch1; mouse, Mus musculus.
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MX M01112 V$RBPJK_01.
MX M01111 V$RBPJK_Q4.
XX
BS R02591.
BS R02592.
BS R28245.
BS R42448.
BS R25016.
BS R42449.
BS R41154.
BS R40914.
BS R62416.
BS R62421.
BS R59852.
BS R59856.
BS R68764.
BS R68765.
BS R68766.
BS R68767.
BS R68768.
BS R68770.
BS R72217.
BS R72221.
BS R41325.
BS R37649.
BS R19594.
XX
DR TRANSPATH: MO000025806.
DR TRANSCOMPEL: C00460.
DR UniProtKB: P31266;
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RN [1]; RE0002064.
RX PUBMED: 2668878.
RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky P.
RT Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells
RL Nucleic Acids Res. 17:5245 (1989).
RN [2]; RE0003605.
RX PUBMED: 7958912.
RA Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilsky P., Schweisguth F., Israel A.
RT Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-Jkappa, by direct protein-protein interaction with Drosophila Hairless
RL Genes Dev. 8:2491-2503 (1994).
RN [3]; RE0003607.
RX PUBMED: 8406481.
RA Amakawa R., Jing W., Ozawa K., Matsunami N., Hamaguchi Y., Matsuda F., Kawaichi M., Honjo T.
RT Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue
RL Genomics 17:306-315 (1993).
RN [4]; RE0003608.
RX PUBMED: 1740450.
RA Kawaichi M., Oka C., Shibayama S., Koromilas A. E., Matsunami N., Honjo T., Hamaguchi Y.
RT Genomic organization of mouse Jkappa recombination signal binding protein (RBP-Jkappa) gene
RL J. Biol. Chem. 267:4016-4022 (1992).
RN [5]; RE0003609.
RX PUBMED: 2556644.
RA Matsunami N., Hamaguchi Y., Yamamoto Y., Kuze K., Kangawa K., Matsuo H., Kawaichi M., Honjo T.
RT A protein binding to the J(K) recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif
RL Nature 342:934-937 (1989).
RN [6]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [7]; RE0055918.
RX PUBMED: 17717603.
RA Kitamura T., Kitamura Y. I., Funahashi Y., Shawber C. J., Castrillon D. H., Kollipara R., DePinho R. A., Kitajewski J., Accili D.
RT A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
RL J. Clin. Invest. 117:2477-2485 (2007).
RN [8]; RE0063439.
RX PUBMED: 18411251.
RA Kim M. Y., Park J. H., Mo J. S., Ann E. J., Han S. O., Baek S. H., Kim K. J., Im S. Y., Park J. W., Choi E. J., Park H. S.
RT Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide.
RL J. Cell Sci. 121:1466-1476 (2008).
RN [9]; RE0068123.
RX PUBMED: 20118921.
RA Ishitani T., Hirao T., Suzuki M., Isoda M., Ishitani S., Harigaya K., Kitagawa M., Matsumoto K., Itoh M.
RT Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
RL Nat. Cell Biol. 12:278-285 (2010).
XX
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