AC T05083
XX
ID T05083
XX
DT 11.04.2002 (created); mas.
DT 23.11.2006 (updated); lyn.
CO Copyright (C), QIAGEN.
XX
FA Hey2
XX
SY basic helix-loop-helix factor 1; CHF1; gridlock; hairy and enhancer of split related-2; hairy-related transcription factor 2; HERP1; Hes-related repressor protein 1; HRT2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004057 Hey2.
XX
HO Hairy (Drosophila).
XX
CL C0010; bHLH; 1.2.4.1.9.
XX
SF deviation from conserved 4-amino-acid code WRPW of Hairy family members: here YQPW (pos. 329-332) [1];
SF belongs to Hairy-related bHLH subfamily (T05077, T05082) with conserved C-terminal motif TE(I/V)GAF [1];
SF basic region (pos. 49-61) but not C terminal region YQPW TE(I/V)GAF (pos. 329-339) necessary for negative autoregulation and binding to E-box motif (CACGTG) [2];
XX
EX aortic arch,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX aortic arch,,,Theiler Stage 23; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX aortic sac,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX aortic sac,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX aortic sac,,,Theiler Stage 23; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX atrium of heart (right and left),,,Theiler Stage 12; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX atrium of heart (right and left),,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX atrium of heart (right and left),,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX atrium of heart (right and left),,,Theiler Stage 23; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; low; Northern blot; total RNA; [4].
EX caudal portion of somites,,,Theiler Stage 13; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX caudal portion of somites,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX caudal portion of somites,,,Theiler Stage 15; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX caudal portion of somites,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX caudal presomitic mesoderm,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cervical somites,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cochlear epithelium,hair cell of internal ear,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cochlear ganglion of cochlear nerve,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cochlear ganglion of cochlear nerve,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX compact myocardial outer layer of ventricle,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX compact myocardial outer layer of ventricle,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX compact zone of ventricle,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cranial sensory ganglion,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cranial sensory ganglion,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cranial sensory ganglion,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX cushion mesenchyme of outlflow tract of heart,,,Theiler Stage 17; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX dermomyotome,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX dermomyotome,,,Theiler Stage 17; none; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX dorsal aorta,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX dorsal aorta,,,Theiler Stage 23; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX dorsal root ganglion,,,Theiler Stage 23; high; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 13; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 14; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX first pharyngeal arch,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX first pharyngeal arch,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX footplate,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX fourth pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX fourth pharyngeal arch,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX ganglion of sympathetic trunk,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX glomerular epithelium,,,Theiler Stage 23; none; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX granular layer of cerebellar cortex,glial cell of central nervous system,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX granular layer of cerebellar cortex,neuron,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX handplate,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX heart,,,Theiler Stage 23; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; high; Northern blot; total RNA; [4].
EX intermediate ganglia,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX junction between mesencephalon and rhombencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; low; Northern blot; total RNA; [4].
EX lens fibers,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX liver,,,adult; none; Northern blot; total RNA; [4].
EX lung,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lung,,,adult; none; Northern blot; total RNA; [4].
EX mandibular process,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX maxillary process,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mesenchyme of hylar vasculature,,,Theiler Stage 23; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX mesenchyme of olfactory bulb,,,Theiler Stage 23; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX mesenchyme surrounding the neural tube,,,Theiler Stage 17; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 20; high; Northern blot; total RNA; [4].
EX muscles,,,adult; very low; Northern blot; total RNA; [4].
EX nasal process,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX neural layer of retina,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX olfactory epithelium,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX olfactory organ,olfactory neuon,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 21; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX otic placode,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX otic placode,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX otic placode,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX otic placode,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX outer cortical plate of the neopallial cortex,,,Theiler Stage 24; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ovary,,,adult; medium; Northern blot; total RNA; [4].
EX paraxial mesoderm,,,Theiler Stage 17; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX posterior branches of primitive heart tube,,,Theiler Stage 12; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX posterior branches of primitive heart tube,,,Theiler Stage 13; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX pre-aortic abdominal sympathetic ganglion,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX presomitic mesoderm (PSM),,,Theiler Stage 13; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX primitive heart tube,,,Theiler Stage 12; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX primitive heart tube,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX pulmonary artery,,,Theiler Stage 23; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rostral presomitic mesoderm,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX rostral presomitic mesoderm,,,Theiler Stage 15; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rostral presomitic mesoderm,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX sclerotome,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX sclerotome,,,Theiler Stage 17; none; RNA-in situ hybridization (radioactive); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX second pharyngeal arch,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX somite 08,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite 09,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite 10,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite 11,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite 12,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX somite,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX somite,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal nerves,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal nerves,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal nerves,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal nerves,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX spinal nerves,,,Theiler Stage 21; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX sympathetic ganglia,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX sympathetic trunk,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX telencephalon,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX telencephalon,,,Theiler Stage 21; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX testis (right and left),,,adult; low; Northern blot; total RNA; [4].
EX third pharyngeal arch,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX third pharyngeal arch,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX trabeculae carneae,,,Theiler Stage 17; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX trigeminal ganglion [V],,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX trigeminal ganglion [V],,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX upper rhombic lip,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ventricle of heart (right and left),,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ventricle of heart (right and left),,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX ventricle of heart (right and left),,,Theiler Stage 15; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX ventricle of heart (right and left),,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX ventricle of heart (right and left),,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX vomeronasal epithelium,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX whisker follicle,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
XX
FF maybe repressor [2];
FF expression positively regulated by Notch signaling (via the Su(H)/RBPJ pathway) [2];
FF negative autoregulation: downregulates expression of its own gene induced by Notch signaling pathway [2];
FF negative autoregulation seems to be independent of HDAC (histone deacetylase) in contrast to distant related H/E(spl) family member Stra13 (compare to T02327) that shows HDAC-dependence [2];
XX
MX M08885 V$HAIRYLIKE_Q3.
XX
DR TRANSPATH: MO000031272.
DR UniProtKB: Q9QUS4;
XX
RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [3]; RE0017199.
RX PUBMED: 10415358.
RA Leimeister C., Externbrink A., Klamt B., Gessler M.
RT Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis
RL Mech. Dev. 85:173-177 (1999).
RN [4]; RE0017656.
RX PUBMED: 10860664.
RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
RL Genomics 66:195-203 (2000).
XX
//