TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02327 XX ID T02327 XX DT 15.01.1998 (created); ewi. DT 07.06.2016 (updated); nes. CO Copyright (C), QIAGEN. XX FA DEC1 XX SY basic helix-loop-helix domain containing, class B2; basic helix-loop-helix family, member e40; BHLHB2; BHLHE40; C130042M06Rik; Clast5; CR8; DEC1; Sharp2; stimulated with RA 13; Stra13; Stra14. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005824 Bhlhe40. XX CL C0010; bHLH; XX SF no heterodimerization with E12; SF homodimers or heterodimers with MASH-1 do not bind to E-box elements interacting with E12/MASH-1 dimers [1]; SF basic domain important for repression [2]; XX CP neuroectoderm; adult brain, female genital tract, heart, kidney, liver, lung, spleen [1]. XX FF repressor of activated transcription [1]; FF may be involved in repressing mesodermal/endodermal differentiation or in inducing neuronal differentiation, at least of P19 cells [1]; FF transcripts increase during embryogenesis from 9.5d to 12.5d p.c. [1]; FF induced by retinoic acid (RA) [1]; FF Dec2 is expressed in the suprachiasmatic nucleus in a circadian fashion, with a peak in the subjective day [3]; XX IN T02327 DEC1; mouse, Mus musculus. IN T23418 HDAC1; mouse, Mus musculus. IN T01619 MASH-1; mouse, Mus musculus. XX MX M02845 V$BHLHB2_04. MX M07078 V$BHLHE40_05. MX M03572 V$DEC1_Q2. MX M08870 V$DEC1_Q3. MX M00997 V$DEC_Q1. MX M08872 V$DEC_Q3. MX M01034 V$EBOX_Q6_01. MX M08885 V$HAIRYLIKE_Q3. MX M00985 V$STRA13_01. XX BS R73544. BS R73543. BS R73521. BS R73538. BS R73541. BS R63914. BS R73546. BS R73542. XX DR TRANSPATH: MO000026324. DR UniProtKB: O35185; BHB2_MOUSE. XX RN [1]; RE0005874. RX PUBMED: 9284045. RA Boudjelal M., Taneja R., Matsubara S., Bouillet P., Dolle P., Chambon P. RT Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells RL Genes Dev. 11:2052-2065 (1997). RN [2]; RE0023863. RX PUBMED: 12297495. RA St-Pierre B., Flock G., Zacksenhaus E., Egan S. E. RT Stra13 homodimers repress transcription through class B E-box elements. RL J. Biol. Chem. 277:46544-46551 (2002). RN [3]; RE0023876. RX PUBMED: 12397359. RA Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K. RT Dec1 and Dec2 are regulators of the mammalian molecular clock. RL Nature 419:841-844 (2002). XX //