AC T02327
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ID T02327
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DT 15.01.1998 (created); ewi.
DT 07.06.2016 (updated); nes.
CO Copyright (C), QIAGEN.
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FA DEC1
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SY basic helix-loop-helix domain containing, class B2; basic helix-loop-helix family, member e40; BHLHB2; BHLHE40; C130042M06Rik; Clast5; CR8; DEC1; Sharp2; stimulated with RA 13; Stra13; Stra14.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005824 Bhlhe40.
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CL C0010; bHLH; 1.2.4.1.12.
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SF no heterodimerization with E12;
SF homodimers or heterodimers with MASH-1 do not bind to E-box elements interacting with E12/MASH-1 dimers [1];
SF basic domain important for repression [2];
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CP neuroectoderm; adult brain, female genital tract, heart, kidney, liver, lung, spleen [1].
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FF repressor of activated transcription [1];
FF may be involved in repressing mesodermal/endodermal differentiation or in inducing neuronal differentiation, at least of P19 cells [1];
FF transcripts increase during embryogenesis from 9.5d to 12.5d p.c. [1];
FF induced by retinoic acid (RA) [1];
FF Dec2 is expressed in the suprachiasmatic nucleus in a circadian fashion, with a peak in the subjective day [3];
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IN T02327 DEC1; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T01619 MASH-1; mouse, Mus musculus.
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MX M02845 V$BHLHB2_04.
MX M07078 V$BHLHE40_05.
MX M03572 V$DEC1_Q2.
MX M08870 V$DEC1_Q3.
MX M00997 V$DEC_Q1.
MX M08872 V$DEC_Q3.
MX M01034 V$EBOX_Q6_01.
MX M08885 V$HAIRYLIKE_Q3.
MX M00985 V$STRA13_01.
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BS R73544.
BS R73543.
BS R73521.
BS R73538.
BS R73541.
BS R63914.
BS R73546.
BS R73542.
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DR TRANSPATH: MO000026324.
DR UniProtKB: O35185; BHB2_MOUSE.
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RN [1]; RE0005874.
RX PUBMED: 9284045.
RA Boudjelal M., Taneja R., Matsubara S., Bouillet P., Dolle P., Chambon P.
RT Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells
RL Genes Dev. 11:2052-2065 (1997).
RN [2]; RE0023863.
RX PUBMED: 12297495.
RA St-Pierre B., Flock G., Zacksenhaus E., Egan S. E.
RT Stra13 homodimers repress transcription through class B E-box elements.
RL J. Biol. Chem. 277:46544-46551 (2002).
RN [3]; RE0023876.
RX PUBMED: 12397359.
RA Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K.
RT Dec1 and Dec2 are regulators of the mammalian molecular clock.
RL Nature 419:841-844 (2002).
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