AC T25617
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ID T25617
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DT 06.06.2002 (created); spi.
DT 09.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA sin3a
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SY Histone deacetylase complex subunit Sin3a; mSin3A; paired amphipathic helix protein Sin3a; Sin3; Sin3a; Transcriptional corepressor Sin3a.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014387 Sin3a.
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IN T34290 Alien; human, Homo sapiens.
IN T06598 AML-1; mouse, Mus musculus.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T09409 C/EBPbeta; mouse, Mus musculus.
IN T01676 EKLF; mouse, Mus musculus.
IN T17417 ESET; mouse, Mus musculus.
IN T00335 GR; mouse, Mus musculus.
IN T17631 HDAC1; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T09068 Hey2; mouse, Mus musculus.
IN T08969 nanog; mouse, Mus musculus.
IN T00671 p53; human, Homo sapiens.
IN T08892 p54NRB-isoform1; human, Homo sapiens.
IN T02235 PEBP2alphaB1; mouse, Mus musculus.
IN T28663 PR B; Mammalia.
IN T08891 PSF-isoform1; human, Homo sapiens.
IN T05934 REST; mouse, Mus musculus.
IN T15014 SNA; human, Homo sapiens.
IN T01799 Tal-1; mouse, Mus musculus.
IN T16151 Tal-1; mouse, Mus musculus.
IN T18813 TIP5; mouse, Mus musculus.
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DR TRANSPATH: MO000031929.
DR UniProtKB: Q60520;
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RN [1]; RE0026627.
RX PUBMED: 10933397.
RA Youn H. D., Liu J. O.
RT Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.
RL Immunity 13:85-94 (2000).
RN [2]; RE0035566.
RX PUBMED: 10688671.
RA Huang S., Brandt S. J.
RT mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
RL Mol. Cell. Biol. 20:2248-2259 (2000).
RN [3]; RE0037094.
RX PUBMED: 12198165.
RA Zhou Y., Santoro R., Grummt I.
RT The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
RL EMBO J. 21:4632-40 (2002).
RN [4]; RE0038190.
RX PUBMED: 11909966.
RA Alland L., David G., Shen-Li H., Potes J., Muhle R., Lee H. C., Hou H. Jr, Chen K., DePinho R. A.
RT Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
RL Mol. Cell. Biol. 22:2743-50 (2002).
RN [5]; RE0047249.
RX PUBMED: 12398767.
RA Yang L., Mei Q., Zielinska-Kwiatkowska A., Matsui Y., Blackburn M. L., Benedetti D., Krumm A. A., Taborsky G. J. Jr, Chansky H. A.
RT An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B
RL Biochem. J. 369:651-7 (2003).
RN [6]; RE0047638.
RX PUBMED: 11960997.
RA David G., Neptune M. A., DePinho R. A.
RT SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
RL J. Biol. Chem. 277:23658-23663 (2002).
RN [7]; RE0047660.
RX PUBMED: 12727880.
RA Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J.
RT Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.
RL EMBO J. 22:2135-2145 (2003).
RN [8]; RE0047677.
RX PUBMED: 11259580.
RA Mathur M., Tucker P. W., Samuels H. H.
RT PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
RL Mol. Cell. Biol. 21:2298-2311 (2001).
RN [9]; RE0047704.
RX PUBMED: 10207062.
RA Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S. P., Renkawitz R., Baniahmad A.
RT Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.
RL Mol. Cell. Biol. 19:3383-3394 (1999).
RN [10]; RE0047781.
RX PUBMED: 12697811.
RA Zika E., Greer S. F., Zhu X. S., Ting J. P.
RT Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.
RL Mol. Cell. Biol. 23:3091-3102 (2003).
RN [11]; RE0047821.
RX PUBMED: 11287616.
RA Chen X., Bieker J. J.
RT Unanticipated repression function linked to erythroid Kruppel-like factor.
RL Mol. Cell. Biol. 21:3118-3125 (2001).
RN [12]; RE0048042.
RX PUBMED: 15542849.
RA Chen X., Bieker J. J.
RT Stage-specific repression by the EKLF transcriptional activator.
RL Mol. Cell. Biol. 24:10416-10424 (2004).
RN [13]; RE0048203.
RX PUBMED: 10688661.
RA Roopra A., Sharling L., Wood I. C., Briggs T., Bachfischer U., Paquette A. J., Buckley N. J.
RT Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex.
RL Mol. Cell. Biol. 20:2147-2157 (2000).
RN [14]; RE0048851.
RX PUBMED: 11486045.
RA Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H. Y., Chung G., Kedes L., Hamamori Y.
RT HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
RL Mol. Cell. Biol. 21:6080-6089 (2001).
RN [15]; RE0049146.
RX PUBMED: 16287841.
RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C.
RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
RL Mol. Cell. Biol. 25:10235-10250 (2005).
RN [16]; RE0064487.
RX PUBMED: 17371839.
RA Lim S., Luo M., Koh M., Yang M., bin Abdul Kadir M. N., Tan J. H., Ye Z., Wang W., Melamed P.
RT Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.
RL Mol. Cell. Biol. 27:4105-4120 (2007).
RN [17]; RE0070143.
RX PUBMED: 19923321.
RA MacPherson M. R., Molina P., Souchelnytskyi S., Wernstedt C., Martin-Perez J., Portillo F., Cano A.
RT Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.
RL Mol. Biol. Cell 21:244-253 (2010).
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