AC T09409
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ID T09409
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DT 13.06.2005 (created); oke.
DT 15.04.2016 (updated); hna.
CO Copyright (C), QIAGEN.
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FA C/EBPbeta
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SY CCAAT/enhancer binding protein (C/EBP), beta; CEBPB; CRP2; IL-6DBP; LAP; NF-IL6; NF-M; Nfil6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005928 Cebpb.
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CL C0008; bZIP; 1.1.8.1.2.
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CP basal layer of epidermis, transitional layer between basal and suprabasal layers of epidermis [15]; Nucleus of WEHI 3BD cells [2]; 3T3L-1 cells treated with Forskolin [16]; macrophage, macrophage + LPS, macrophage + LPS + PD98059, macrophage + LPS + Ro318220 [6]; RAW264.7, RAW264.7 + LPS + IFNgamma, RAW264.7 + LPS + IFNgamma + alpha-MSH [4].
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FF The affinity of C/EBPbeta binding to Nupr1 G042247 promoter is less than C/EBPalpha [5];
FF induced by diabetes [14];
FF Gluconeogenesis, and PEPCK G000782 expression are lower in C/EBPbeta-/- mice during streptozotocin-induced diabetes [14];
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IN T08444 ATF-4; mouse, Mus musculus.
IN T09623 ATF-6; human, Homo sapiens.
IN T15118 CBP; Mammalia.
IN T19612 DRIP205; mouse, Mus musculus.
IN T02532 GATA-4; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T25617 sin3a; mouse, Mus musculus.
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MX M00109 V$CEBPB_01.
MX M00117 V$CEBPB_02.
MX M07413 V$CEBPB_07.
MX M07315 V$CEBPB_Q3.
MX M01896 V$CEBPB_Q6.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
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BS R24880.
BS R27493.
BS R22149.
BS R39946.
BS R40463.
BS R69689.
BS R56143.
BS R27492.
BS R32278.
BS R31416.
BS R59374.
BS R23181.
BS R14487.
BS R13567.
BS R37773.
BS R24918.
BS R21594.
BS R08091.
BS R29715.
BS R42260.
BS R42264.
BS R32324.
BS R35995.
BS R60521.
BS R60218.
BS R60219.
BS R20543.
BS R57602.
BS R25422.
BS R65829.
BS R65831.
BS R65964.
BS R63353.
BS R40806.
BS R40797.
BS R03135.
BS R28460.
BS R67420.
BS R60822.
BS R37804.
BS R37806.
BS R35383.
BS R70469.
BS R26449.
BS R33469.
BS R41320.
BS R40802.
BS R28687.
BS R21771.
BS R35701.
BS R67676.
BS R67677.
BS R58406.
BS R29490.
BS R63552.
BS R26269.
BS R14479.
BS R65033.
BS R64703.
BS R23524.
BS R64704.
BS R40796.
BS R36284.
BS R21343.
BS R21344.
BS R26887.
BS R20515.
BS R40798.
BS R29228.
BS R60839.
BS R26872.
BS R21754.
BS R21755.
BS R08130.
BS R64701.
BS R28302.
BS R20505.
BS R29474.
BS R41330.
BS R37680.
BS R59014.
BS R19656.
BS R27604.
BS R62242.
BS R62250.
BS R13172.
BS R39010.
BS R62741.
BS R62742.
BS R26718.
BS R67929.
BS R67930.
BS R66625.
BS R66626.
BS R13310.
BS R42044.
BS R67116.
BS R29343.
BS R29564.
BS R33248.
BS R33249.
BS R63925.
BS R62440.
BS R64705.
BS R72787.
BS R72788.
BS R63821.
BS R40265.
BS R71285.
BS R21352.
BS R72417.
BS R31420.
BS R20960.
BS R21278.
BS R30715.
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DR TRANSPATH: MO000056021.
DR TRANSCOMPEL: C00554.
DR TRANSCOMPEL: C00565.
DR TRANSCOMPEL: C00575.
DR TRANSCOMPEL: C00625.
DR UniProtKB: P28033;
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RN [1]; RE0028650.
RX PUBMED: 11012671.
RA Jung N., Yi Y. W., Kim D., Shong M., Hong S. S., Lee H. S., Bae I.
RT Regulation of Gadd45gamma expression by C/EBP.
RL Eur. J. Biochem. 267:6180-7 (2000).
RN [2]; RE0034223.
RX PUBMED: 8855267.
RA Ford A. M., Bennett C. A., Healy L. E., Towatari M., Greaves M. F., Enver T.
RT Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification.
RL Proc. Natl. Acad. Sci. USA 93:10838-43 (1996).
RN [3]; RE0036087.
RX PUBMED: 12239105.
RA Tremblay J. J., Hamel F., Viger R. S.
RT Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.
RL Endocrinology 143:3935-3945 (2002).
RN [4]; RE0038533.
RX PUBMED: 10844594.
RA Gupta A. K., Diaz R. A., Higham S., Kone B. C.
RT alpha-MSH inhibits induction of C/EBPbeta-DNA binding activity and NOS2 gene transcription in macrophages
RL Kidney Int. 57:2239-48 (2000).
RN [5]; RE0041442.
RX PUBMED: 10510303.
RA Vasseur S., Mallo G. V., Garcia-Montero A., Ortiz E. M., Fiedler F., Canepa E., Moreno S., Iovanna J. L.
RT Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter
RL Biochem. J. 343:377-83 (1999).
RN [6]; RE0043219.
RX PUBMED: 12234923.
RA Eliopoulos A. G., Dumitru C. D., Wang C. C., Cho J., Tsichlis P. N.
RT Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals
RL EMBO J. 21:4831-40 (2002).
RN [7]; RE0047660.
RX PUBMED: 12727880.
RA Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J.
RT Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.
RL EMBO J. 22:2135-2145 (2003).
RN [8]; RE0047996.
RX PUBMED: 15985551.
RA Tang Q. Q., Gronborg M., Huang H., Kim J. W., Otto T. C., Pandey A., Lane M. D.
RT Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis.
RL Proc. Natl. Acad. Sci. USA 102:9766-9771 (2005).
RN [9]; RE0048226.
RX PUBMED: 10635333.
RA Buck M., Poli V., van der Geer P., Chojkier M., Hunter T.
RT Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.
RL Mol. Cell 4:1087-1092 (1999).
RN [10]; RE0048242.
RX PUBMED: 15644333.
RA Bezy O., Elabd C., Cochet O., Petersen R. K., Kristiansen K., Dani C., Ailhaud G., Amri E. Z.
RT Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation.
RL J. Biol. Chem. 280:11432-11438 (2005).
RN [11]; RE0048262.
RX PUBMED: 16210377.
RA Singh R., Artaza J. N., Taylor W. E., Braga M., Yuan X., Gonzalez-Cadavid N. F., Bhasin S.
RT Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors.
RL Endocrinology 147:141-154 (2006).
RN [12]; RE0048416.
RX PUBMED: 16144835.
RA Kim I. M., Zhou Y., Ramakrishna S., Hughes D. E., Solway J., Costa R. H., Kalinichenko V. V.
RT Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.
RL J. Biol. Chem. 280:37908-37916 (2005).
RN [13]; RE0049611.
RX PUBMED: 17110376.
RA Cesena T. I., Cardinaux J. R., Kwok R., Schwartz J.
RT CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription.
RL J. Biol. Chem. 282:956-967 (2007).
RN [14]; RE0049653.
RX PUBMED: 10224054.
RA Arizmendi C., Liu S., Croniger C., Poli V., Friedman J. E.
RT The transcription factor CCAAT/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.
RL J. Biol. Chem. 274:13033-13040 (1999).
RN [15]; RE0050103.
RX PUBMED: 10588870.
RA Maytin E. V., Lin J. C., Krishnamurthy R., Batchvarova N., Ron D., Mitchell P. J., Habener J. F.
RT Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.
RL Dev. Biol. 216:164-181 (1999).
RN [16]; RE0052047.
RX PUBMED: 16837116.
RA Gout J., Tirard J., Thevenon C., Riou J. P., Begeot M., Naville D.
RT CCAAT/enhancer-binding proteins (C/EBPs) regulate the basal and cAMP-induced transcription of the human 11beta-hydroxysteroid dehydrogenase encoding gene in adipose cells.
RL Biochimie 88:1115-1124 (2006).
RN [17]; RE0053048.
RX PUBMED: 17724128.
RA Yamamoto M., Uematsu S., Okamoto T., Matsuura Y., Sato S., Kumar H., Satoh T., Saitoh T., Takeda K., Ishii K. J., Takeuchi O., Kawai T., Akira S.
RT Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
RL J. Exp. Med. 204:2233-2239 (2007).
RN [18]; RE0063561.
RX PUBMED: 18339625.
RA Li H., Gade P., Nallar S. C., Raha A., Roy S. K., Karra S., Reddy J. K., Reddy S. P., Kalvakolanu D. V.
RT The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma.
RL J. Biol. Chem. 283:13077-13086 (2008).
RN [19]; RE0064596.
RX PUBMED: 17456598.
RA Maitra A., Shen F., Hanel W., Mossman K., Tocker J., Swart D., Gaffen S. L.
RT Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression.
RL Proc. Natl. Acad. Sci. USA 104:7506-7511 (2007).
RN [20]; RE0064819.
RX PUBMED: 19244213.
RA Shen F., Li N., Gade P., Kalvakolanu D. V., Weibley T., Doble B., Woodgett J. R., Wood T. D., Gaffen S. L.
RT IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.
RL Sci. Signal. 2:ra8 (2009).
RN [21]; RE0065417.
RX PUBMED: 19454718.
RA Lu Y. C., Kim I., Lye E., Shen F., Suzuki N., Suzuki S., Gerondakis S., Akira S., Gaffen S. L., Yeh W. C., Ohashi P. S.
RT Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.
RL J. Immunol. 182:7212-7221 (2009).
RN [22]; RE0069441.
RX PUBMED: 15383601.
RA Hu B., Wu Z., Jin H., Hashimoto N., Liu T., Phan S. H.
RT CCAAT/enhancer-binding protein beta isoforms and the regulation of alpha-smooth muscle actin gene expression by IL-1 beta.
RL J. Immunol. 173:4661-4668 (2004).
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