AC T02532
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ID T02532
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DT 09.12.1998 (created); ewi.
DT 26.12.2014 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA GATA-4
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SY GATA-binding factor 4.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004484 Gata4.
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CL C0004; CC; 2.2.1.1.4.
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SF the C-terminal zinc finger plus the adjacent basic domain (251-324) are necessary and sufficient for DNA-binding [5];
SF the region around the C-terminal zinc finger (251-324) also contains a nuclear localization signal [5];
SF N- and C-terminal sequences are required for transcriptional activation [5];
SF efficient binding of GATA-4 T02532 to PSA4 R15275 requires the region adjacent to the basic domain as well as both zinc fingers but not to PS13 R15276 [9];
SF DNA bending by GATA-4 T02532 shows differences in conformation between the complexes formed on PSA4 R15275 and PS13 R15276 [9];
XX
CP parietal endoderm, visceral endoderm, embryonic mesoderm at mouse embryonic day (E) 7,5 [7]; heart, primitive endoderm, proximal and distal gut, ovary, testis, liver in embryonic and fetal mice [9] [7] [9]; Goblet cells in small intestine. [18]; testis, MA-10 cells [14].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; none; Northern blot; total RNA; [1].
EX descending aorta,,,fetal; none; RNA-in situ hybridization (not further specified); RNA (undefined); [20].
EX heart,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX heart,,,Theiler Stage 25; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; detectable; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [1].
EX large intestine,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lung,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX outflow tract of heart,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX ovary,,,adult; detectable; Northern blot; total RNA; [1].
EX parietal endoderm,,,Theiler Stage 6; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX primitive seminiferous tubules,primordial germ cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX pulmonary artery,,,fetal; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [20].
EX seminal vesicle,,,adult; none; Northern blot; total RNA; [1].
EX septum transversum,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX small intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; none; Northern blot; total RNA; [1].
EX testis (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),stromal cell,,Theiler Stage 22; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX thymus,,,adult; none; Northern blot; total RNA; [1].
EX trophectoderm,,,Theiler Stage 6; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX uterus,,,adult; none; Northern blot; total RNA; [1].
EX visceral endoderm,,,Theiler Stage 10; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX visceral yolk sac,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
XX
FF expressed at time and place of heart development [2];
FF required for cardiac muscle-specific gene expression in DMSO-treated P19 cells [3];
FF ectopic expression can rescue erythroid differentiation of GATA-1 T00305 deficient murine embryonic stem cells [4];
FF coimmunoprecipitation experiments demonstrate that Nkx2.5 T01675 and Gata4 associate intracellularly, helix III of the homeodomain of Nkx2.5 is required to interact with Gata4 and the carboxyl-terminal zinc finger of Gata4 is necessary to associate with Nkx2.5 [10];
FF Gata 4 can activate ANF promoter and coexpression of Nkx2.5 and Gata4 shows synergistically activation [10];
FF Nkx2.5 T01675 and Gata4 synergistically transactivate the human but not the rat DIO2 promoter [11];
XX
IN T09409 C/EBPbeta; mouse, Mus musculus.
IN T01675 CSX; mouse, Mus musculus.
IN T16154 EZH2; mouse, Mus musculus.
IN T18923 ZFPM2-isoform1; mouse, Mus musculus.
IN T18922 ZFPM2; mouse, Mus musculus.
XX
MX M07096 V$GATA4_03.
MX M00632 V$GATA4_Q3.
MX M03549 V$GATA4_Q5_01.
MX M00789 V$GATA_Q6.
XX
BS R23675.
BS R19518.
BS R19520.
BS R19597.
BS R32657.
BS R16087.
BS R16089.
BS R30056.
BS R02969.
BS R32658.
BS R18691.
BS R41247.
BS R41248.
BS R15276.
BS R32045.
BS R38359.
BS R08264.
BS R28705.
BS R19766.
BS R20200.
BS R20201.
BS R20204.
BS R40123.
BS R35557.
BS R35558.
BS R35559.
BS R40462.
BS R23092.
BS R32079.
BS R32131.
BS R32133.
BS R59415.
BS R15859.
BS R61607.
BS R27447.
BS R27448.
BS R27450.
BS R28700.
BS R22291.
BS R08150.
BS R20755.
BS R20756.
BS R37952.
BS R13027.
BS R08287.
XX
DR TRANSPATH: MO000026512.
DR UniProtKB: Q08369;
XX
RN [1]; RE0007092.
RX PUBMED: 8455608.
RA Arceci R. J., King A. A., Simon M. C., Orkin S. H., Wilson D. B.
RT Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
RL Mol. Cell. Biol. 13:2235-2246 (1993).
RN [2]; RE0009877.
RX PUBMED: 7935467.
RA Ip H. S., Wilson D. B., Heikinheimo M., Tang Z., Ting C.-N., Simon M. C., Leiden J. M., Parmacek M. S.
RT The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells
RL Mol. Cell. Biol. 14:7517-7526 (1994).
RN [3]; RE0010631.
RX PUBMED: 7623805.
RA Grepin C., Robitaille L., Antakly T., Nemer M.
RT Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation
RL Mol. Cell. Biol. 15:4095-4102 (1995).
RN [4]; RE0013446.
RX PUBMED: 7823931.
RA Blobel G. A., Simon M. C., Orkin S. H.
RT Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins.
RL Mol. Cell. Biol. 15:626-633 (1995).
RN [5]; RE0013540.
RX PUBMED: 9079680.
RA Morrisey E. E., Ip H. S., Tang Z., Parmacek M. S.
RT GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily.
RL J. Biol. Chem. 272:8515-8524 (1997).
RN [6]; RE0021481.
RX PUBMED: 11382772.
RA Morisco C., Seta K., Hardt S. E., Lee Y., Vatner S. F., Sadoshima J.
RT Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes
RL J. Biol. Chem. 276:28586-28597 (2001).
RN [7]; RE0024427.
RX PUBMED: 15082719.
RA Murakami A., Shen H., Ishida S., Dickson C.
RT SOX7 and GATA-4 are competitive activators of Fgf-3 transcription.
RL J. Biol. Chem. 279:28564-28573 (2004).
RN [8]; RE0024471.
RX PUBMED: 10358083.
RA Murakami A., Thurlow J., Dickson C.
RT Retinoic acid-regulated expression of fibroblast growth factor 3 requires the interaction between a novel transcription factor and GATA-4.
RL J. Biol. Chem. 274:17242-17248 (1999).
RN [9]; RE0024473.
RX PUBMED: 11842118.
RA Murakami A., Ishida S., Dickson C.
RT GATA-4 interacts distinctively with negative and positive regulatory elements in the Fgf-3 promoter.
RL Nucleic Acids Res. 30:1056-1064 (2002).
RN [10]; RE0025078.
RX PUBMED: 9584153.
RA Lee Y., Shioi T., Kasahara H., Jobe S. M., Wiese R. J., Markham B. E., Izumo S.
RT The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.
RL Mol. Cell. Biol. 18:3120-3129 (1998).
RN [11]; RE0025173.
RX PUBMED: 12775767.
RA Dentice M., Morisco C., Vitale M., Rossi G., Fenzi G., Salvatore D.
RT The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors.
RL Mol. Endocrinol. 17:1508-1521 (2003).
RN [12]; RE0025457.
RX PUBMED: 12411391.
RA Bueno O. F., Molkentin J. D.
RT Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death.
RL Circ. Res. 91:776-781 (2002).
RN [13]; RE0025458.
RX PUBMED: 11585926.
RA Liang Q., Wiese R. J., Bueno O. F., Dai Y. S., Markham B. E., Molkentin J. D.
RT The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.
RL Mol. Cell. Biol. 21:7460-7469 (2001).
RN [14]; RE0027116.
RX PUBMED: 9514155.
RA Feng Z. M., Wu A. Z., Chen C. L.
RT Testicular GATA-1 factor up-regulates the promoter activity of rat inhibin alpha-subunit gene in MA-10 Leydig tumor cells.
RL Mol. Endocrinol. 12:378-90 (1998).
RN [15]; RE0036087.
RX PUBMED: 12239105.
RA Tremblay J. J., Hamel F., Viger R. S.
RT Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.
RL Endocrinology 143:3935-3945 (2002).
RN [16]; RE0046950.
RX PUBMED: 9927675.
RA Svensson E. C., Tufts R. L., Polk C. E., Leiden J. M.
RT Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes
RL Proc. Natl. Acad. Sci. USA 96:956-61 (1999).
RN [17]; RE0047105.
RX PUBMED: 15793308.
RA Gianakopoulos P. J., Skerjanc I. S.
RT Hedgehog signaling induces cardiomyogenesis in P19 cells
RL J. Biol. Chem. 280:21022-8 (2005).
RN [18]; RE0048853.
RX PUBMED: 15541382.
RA van der Sluis M., Melis M. H., Jonckheere N., Ducourouble M. P., Buller H. A., Renes I., Einerhand A. W., Van Seuningen I.
RT The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
RL Biochem. Biophys. Res. Commun. 325:952-960 (2004).
RN [19]; RE0051652.
RX PUBMED: 11382775.
RA Huggins G. S., Bacani C. J., Boltax J., Aikawa R., Leiden J. M.
RT Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter.
RL J. Biol. Chem. 276:28029-28036 (2001).
RN [20]; RE0013564.
RX PUBMED: 8812463.
RA Narita N., Heikinheimo M., Bielinska M., White R. A., Wilson D. B.
RT The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle.
RL Genomics 36:345-348 (1996).
XX
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