TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00335 XX ID T00335 XX DT 15.10.1992 (created); ewi. DT 29.05.2016 (updated); mom. CO Copyright (C), QIAGEN. XX FA GR XX SY glucocorticoid receptor; GR; GRL; GRL1; NR3C1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005283 Nr3c1. XX CL C0002; CC (rec); XX SF the first zinc finger of the DBD binds specifically to the GRE, the second enhances the affinity [4]; SF essential for GRE/ERE discrimination: knuckle of the 1st zinc finger (GS vs. EG); SF ligand-binding domain (LBD) contains a long helix, H9, with 30 residues, and exhibits slight deformation when the receptor binds its cognate ligands (cortisol) [15]; SF LBD has a 12-residue C-terminal extension (residues 772-783) that is essential for hormone binding and which is fixed in position by interaction with certain residues of antiparallel beta-sheets S3 (pos. 680-682) and S4 (pos. 775-777) [15]; XX IN T00029 AP-1; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T00335 GR; mouse, Mus musculus. IN T23418 HDAC1; mouse, Mus musculus. IN T09997 Hsp90; mouse, Mus musculus. IN T17766 MR (NR3C2); mouse, Mus musculus. IN T10542 p300; mouse, Mus musculus. IN T08131 Pbx1; mouse, Mus musculus. IN T25617 sin3a; mouse, Mus musculus. IN T04597 SKIP; human, Homo sapiens. IN T01579 STAT5A; mouse, Mus musculus. IN T00944 STAT5B; mouse, Mus musculus. IN T19335 TIF1a-short; human, Homo sapiens. IN T02482 TIF2; mouse, Mus musculus. XX MX M00205 V$GRE_C. MX M00955 V$GR_01. MX M08998 V$GR_02. MX M07355 V$GR_Q4. MX M00192 V$GR_Q6. MX M00921 V$GR_Q6_01. MX M01836 V$GR_Q6_02. MX M00960 V$PR_Q2. XX BS R27057. BS R31352. BS R02163. BS R12350. BS R28967. BS R65243. BS R65245. BS R01146. BS R01147. BS R02043. BS R64477. BS R40896. BS R72230. BS R62851. BS R31298. BS R31299. BS R56945. BS R01312. BS R01313. BS R28966. BS R71762. BS R71763. BS R55907. BS R55911. BS R71296. BS R63012. BS R62375. BS R64576. BS R65086. BS R65088. BS R65089. BS R65092. BS R65093. BS R66529. BS R65797. BS R66067. BS R62133. BS R38648. BS R73285. BS R73287. BS R01645. BS R74043. BS R74044. BS R14392. XX DR TRANSPATH: MO000021666. DR TRANSCOMPEL: C00298. DR TRANSCOMPEL: C00518. DR UniProtKB: P06537; XX RN [1]; RE0001316. RX PUBMED: 3561410. RA Speck N. A., Baltimore D. RT Six distinct nuclear factors interact with the 75-base-pair repeat of the moloney murine leukemia virus enhancer RL Mol. Cell. Biol. 7:1101-1110 (1987). RN [2]; RE0001831. RX PUBMED: 2867473. RA Hollenberg S. M., Weinberger C., Ong E. S., Cerelli G., Oro A., Lebo R., Thompson E. B., Rosenfeld G. M., Evans R. M. RT Primary structure and expression of a functional human glucocorticoid receptor cDNA RL Nature 318:635-641 (1985). RN [3]; RE0002752. RX PUBMED: 2157044. RA Gorska-Flipot I., Jolicoeur P. RT DNA-Binding Proteins That Interact with the Long Terminal Repeat of Radiation Leukemia Virus RL J. Virol. 64:1566-1572 (1990). RN [4]; RE0002790. RX PUBMED: 2500250. RA Danielsen M., Hinck L., Ringold G. M. RT Two amino acids within the knuckle of the first zinc finger specificy DNA response element activation by the glucocorticoid receptor RL Cell 57:1131-1138 (1989). RN [5]; RE0002811. RX PUBMED: 2376573. RA Housley P. R., Sanchez E. R., Danielsen M., Ringold G. M., Pratt W. B. RT Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain RL J. Biol. Chem. 265:12778-12781 (1990). RN [6]; RE0002812. RX PUBMED: 2243084. RA Sanchez E. R., Hirst M., Scherrer L. C., Tang H.-Y., Welsh M. J., Harmon J. M., Simons jr S. S., Ringold G. M., Pratt W. B. RT Hormone-free mouse glucocorticoid receptors overexpressed in chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90 RL J. Biol. Chem. 265:20123-20130 (1990). RN [7]; RE0002813. RX PUBMED: 2266108. RA Sanchez E. R. RT Hsp56: A novel heat shock protein associated with untransformed steroid receptor complexes RL J. Biol. Chem. 265:22067-22070 (1990). RN [8]; RE0003691. RX PUBMED: 3780669. RA Danielsen M., Northrop P., Ringold G. M. RT The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins RL EMBO J. 5:2513-2522 (1986). RN [9]; RE0003697. RX PUBMED: 6351915. RA Gehring U., Hotz A. RT Photoaffinity labeling and partial proteolysis of wild-type and variant glucocorticoid receptors RL Biochemistry 22:4013-4018 (1983). RN [10]; RE0003701. RX PUBMED: 1761557. RA Rexin M., Busch M., Gehring U. RT Protein components of the nonactivated glucocorticoid receptor RL J. Biol. Chem. 266:24601-24604 (1991). RN [11]; RE0003702. RX PUBMED: 3900074. RA Sanchez E. R., Toft D. O., Schlesinger M. J., Pratt W. B. RT Evidence that the 90-kDa-phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein RL J. Biol. Chem. 260:12398-12401 (1985). RN [12]; RE0003711. RX PUBMED: 8132510. RA Chen D., Stallup M. R. RT The hormone-binding role of the 2 cysteins near the C-terminus of the mouse glucocorticoid receptor RL J. Biol. Chem. 269:7914-7918 (1994). RN [13]; RE0016574. RX PUBMED: 2119054. RA Diamond M. I., Miner J. N., Yoshinaga S. K., Yamamoto K. R. RT Transcription factor interactions: selectors of positive or negative regulation form a single DNA element. RL Science 249:1266-1272 (1990). RN [14]; RE0017308. RX PUBMED: 9115274. RA Thenot S., Henriquet C., Rochefort H., Cavailles V. RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 RL J. Biol. Chem. 272:12062-12068 (1997). RN [15]; RE0017682. RX PUBMED: 11579225. RA Dey R., Roychowdhury P., Mukherjee C. RT Homology modelling of the ligand-binding domain of glucocorticoid receptor: binding site interactions with cortisol and corticosterone. RL Protein Eng. 14:565-571 (2001). RN [16]; RE0042412. RX PUBMED: 9528750. RA Cella N., Groner B., Hynes N. E. RT Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells RL Mol. Cell. Biol. 18:1783-92 (1998). RN [17]; RE0047167. RX PUBMED: 15137909. RA Huang S. M., Cheng Y. S. RT Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1 RL Biochem. J. 382:111-9 (2004). RN [18]; RE0047660. RX PUBMED: 12727880. RA Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J. RT Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. RL EMBO J. 22:2135-2145 (2003). RN [19]; RE0047783. RX PUBMED: 15485845. RA Harrell J. M., Murphy P. J., Morishima Y., Chen H., Mansfield J. F., Galigniana M. D., Pratt W. B. RT Evidence for glucocorticoid receptor transport on microtubules by dynein. RL J. Biol. Chem. 279:54647-54654 (2004). RN [20]; RE0047786. RX PUBMED: 12487626. RA Subramaniam N., Campion J., Rafter I., Okret S. RT Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1. RL Biochem. J. 370:1087-1095 (2003). RN [21]; RE0047997. RX PUBMED: 15870285. RA Ki S. H., Cho I. J., Choi D. W., Kim S. G. RT Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. RL Mol. Cell. Biol. 25:4150-4165 (2005). RN [22]; RE0066762. RX PUBMED: 19638349. RA Stow L. R., Gumz M. L., Lynch I. J., Greenlee M. M., Rudin A., Cain B. D., Wingo C. S. RT Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1). RL J. Biol. Chem. 284:30087-30096 (2009). XX //