AC T00944
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ID T00944
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DT 22.06.1993 (created); ewi.
DT 11.05.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA STAT5B
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SY mammary gland factor; MGF; signal transducer and activator of transcription 5 A; signal transducer and activator of transcription 5B; STAT5B; STF-IL-3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006768 Stat5b.
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CL C0039; STAT; 6.2.1.0.6.
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SF highly related to STAT5A, but encoded by a different gene [4];
SF DNA-binding depends on phosphorylation by casein kinase II (in vitro) [1];
SF tyrosine 699 phosphorylation most likely by Jak2 [3];
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CP high in lactating mammary gland, thymus spleen; moderate in bone marrow, heart, kidney, lung [3] [4]; in pancreatic beta cells level is higher than that of STAT5A [8] [3] [4] [8]; CommaD cells [18]; Bone marrow derived macrophages treated with CSF [19].
CN very low or undetectable in brain, intestine, liver [3] [4].
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FF IFN-gamma/LPS treatment of RAW 264.7 results in marked reduction in the STAT5b protein level in nucleus, and drastic reduction in cytosol to the level of almost total absence [12];
FF binding activity of MGF increases at the end of pregnancy, strong during lactation, decreases upon withdrawal of the pups;
FF mediates response to several cytokines and hormones, in particular to IL-2, IL-5, GM-CSF, erythropoietin [2] [4];
FF mediates response to growth hormone in pancreatic beta-cells [8];
FF needs to be Tyr-phosphorylated and activated by Hck and Abl for binding to the Fc gamma RI promoter [7];
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IN T00335 GR; mouse, Mus musculus.
IN T01579 STAT5A; mouse, Mus musculus.
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MX M00459 V$STAT5B_01.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
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BS R14619.
BS R14236.
BS R15672.
BS R11115.
BS R30840.
BS R24153.
BS R35575.
BS R15296.
BS R73122.
BS R59492.
BS R59494.
BS R59495.
BS R03322.
BS R04917.
BS R19622.
BS R04650.
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DR TRANSPATH: MO000013134.
DR UniProtKB: P42232;
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RN [1]; RE0002516.
RX PUBMED: 1557422.
RA Schmitt-Ney M., Happ B., Ball R. K., Groner B.
RT Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein
RL Proc. Natl. Acad. Sci. USA 89:3130-3134 (1992).
RN [2]; RE0003483.
RX PUBMED: 7760829.
RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N.
RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis
RL Mol. Cell. Biol. 15:3336-3343 (1995).
RN [3]; RE0003485.
RX PUBMED: 7537213.
RA Azam M., Erdjument-Bromage H., Kreider B. L., Xia M., Quelle F., Basu R., Saris C., Tempst P., Ihle J. N., Schindler C.
RT Interleukin-3 signals through multiple isoforms of Stat5
RL EMBO J. 14:1402-1411 (1995).
RN [4]; RE0003486.
RX PUBMED: 7720707.
RA Mui A. L.-F., Wakao H., OFarrell A.-M., Harada N., Miyajima A.
RT Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
RL EMBO J. 14:1166-1175 (1995).
RN [5]; RE0006063.
RX PUBMED: 9009201.
RA Liu X., Robinson G. W., Wagner K.-U., Garrett L., Wynshaw-Boris A., Hennighausen L.
RT Stat5a is mandatory for adult mammary gland development and lactogenesis
RL Genes Dev. 11:179-186 (1997).
RN [6]; RE0010933.
RX PUBMED: 7568026.
RA Liu X., Robinson G. W., Gouilleux F., Groner B., Hennighausen L.
RT Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
RL Proc. Natl. Acad. Sci. USA 92:8831-8835 (1995).
RN [7]; RE0023476.
RX PUBMED: 12411494.
RA Klejman A., Schreiner S. J., Nieborowska-Skorska M., Slupianek A., Wilson M., Smithgall T. E., Skorski T.
RT The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
RL EMBO J. 21:5766-5774 (2002).
RN [8]; RE0024498.
RX PUBMED: 12586844.
RA Friedrichsen B. N., Richter H. E., Hansen J. A., Rhodes C. J., Nielsen J. H., Billestrup N., Moldrup A.
RT Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
RL Mol. Endocrinol. 17:945-958 (2003).
RN [9]; RE0029733.
RX PUBMED: 10026141.
RA Al-Shami A., Naccache P. H.
RT Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase.
RL J. Biol. Chem. 274:5333-8 (1999).
RN [10]; RE0042419.
RX PUBMED: 12429742.
RA Kloth M. T., Laughlin K. K., Biscardi J. S., Boerner J. L., Parsons S. J., Silva C. M.
RT STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
RL J. Biol. Chem. 278:1671-9 (2003).
RN [11]; RE0047437.
RX PUBMED: 16199887.
RA Tannahill G. M., Elliott J., Barry A. C., Hibbert L., Cacalano N. A., Johnston J. A.
RT SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.
RL Mol. Cell. Biol. 25:9115-9126 (2005).
RN [12]; RE0050406.
RX PUBMED: 16886906.
RA Starzynski R. R., Goncalves A. S., Muzeau F., Tyrolczyk Z., Smuda E., Drapier J. C., Beaumont C., Lipinski P.
RT STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.
RL Biochem. J. 400:367-375 (2006).
RN [13]; RE0050972.
RX PUBMED: 16155412.
RA Joung Y. H., Lim E. J., Lee M. Y., Park J. H., Ye S. K., Park E. U., Kim S. Y., Zhang Z., Lee K. J., Park D. K., Park T., Moon W. K., Yang Y. M.
RT Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
RL Exp. Mol. Med. 37:353-364 (2005).
RN [14]; RE0051815.
RX PUBMED: 11133161.
RA Gallego M. I., Binart N., Robinson G. W., Okagaki R., Coschigano K. T., Perry J., Kopchick J. J., Oka T., Kelly P. A., Hennighausen L.
RT Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
RL Dev. Biol. 229:163-175 (2001).
RN [15]; RE0051994.
RX PUBMED: 11981045.
RA Nevalainen M. T., Xie J., Bubendorf L., Wagner K. U., Rui H.
RT Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium.
RL Mol. Endocrinol. 16:1108-1124 (2002).
RN [16]; RE0052366.
RX PUBMED: 16754961.
RA Akhtar N., Streuli C. H.
RT Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia.
RL J. Cell Biol. 173:781-793 (2006).
RN [17]; RE0052420.
RX PUBMED: 8961260.
RA Liu X., Robinson G. W., Hennighausen L.
RT Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.
RL Mol. Endocrinol. 10:1496-1506 (1996).
RN [18]; RE0052702.
RX PUBMED: 11369441.
RA Wheeler T. T., Broadhurst M. K., Sadowski H. B., Farr V. C., Prosser C. G.
RT Stat5 phosphorylation status and DNA-binding activity in the bovine and murine mammary glands.
RL Mol. Cell. Endocrinol. 176:39-48 (2001).
RN [19]; RE0052744.
RX PUBMED: 9292509.
RA Feldman G. M., Rosenthal L. A., Liu X., Hayes M. P., Wynshaw-Boris A., Leonard W. J., Hennighausen L., Finbloom D. S.
RT STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression.
RL Blood 90:1768-1776 (1997).
RN [20]; RE0053210.
RX PUBMED: 9630227.
RA Teglund S., McKay C., Schuetz E., van Deursen J. M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., Ihle J. N.
RT Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.
RL Cell 93:841-850 (1998).
RN [21]; RE0054272.
RX PUBMED: 11604235.
RA Yamashita H., Nevalainen M. T., Xu J., LeBaron M. J., Wagner K. U., Erwin R. A., Harmon J. M., Hennighausen L., Kirken R. A., Rui H.
RT Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.
RL Mol. Cell. Endocrinol. 183:151-163 (2001).
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