AC T01579
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ID T01579
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DT 24.11.1995 (created); ewi.
DT 10.07.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA STAT5A
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SY mammary gland factor; MGF; MPF; signal transducer and activator of transcription 5 A; signal transducer and activator of transcription 5A; Signal Transducer and Activator of Transcription 5alpha; STAT5A; STF-IL-3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006767 Stat5a.
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CL C0039; STAT; 6.2.1.0.5.
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SF highly related to STAT5B, but encoded by a different gene [3];
SF transactivation domain is necessary for interactions with Oct-1 [10];
SF Oct-1 binding motif is conserved in several different proteins, STAT5A, OBF-1, SNAP190 [10];
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CP high in lactating mammary gland, thymus spleen; moderate in bone marrow, heart, kidney, lung [2] [3]; HC11, HC11+DFO, HC11+hypoxia [24]; Increased expression in mammary tissues during pregnancy [25]; Bone marrow derived macrophages treated with CSF [26].
CN brain, intestine, liver [2] [3].
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FF IFN-gamma/LPS treatment of RAW 264.7 results in drastic reduction in STAT5a in cytosol to the level of almost total absence [16];
FF STAT5A1*6;
FF an active mutant form of STAT5A facilitates IL6 production in MD cells and thereby induces macrophage differentiation of parental M1 cells [27];
FF STAT5A1*6;
FF an active mutant form of STAT5A induces the activation of STAT3 through mechanisms other than forming heterodimers with STAT3 [27];
FF activator;
FF mediates response to several cytokines and hormones, in particular to IL-2, IL-5, GM-CSF, erythropoietin, prolactin [1] [3] [11];
FF activated by IL-10 and IL-3 [6];
FF SHP-2 is present in the STAT5A-DNA-binding complex of the rat beta-casein promoter evidenced by antibody supershift [7];
FF both forms of STAT5A - glycosylated and non-glycosylated - bind to the CSN2 promoter, however, only the glycosylated form will activate transcription during PRL stimulation [8];
FF PRL stimulates Jak2 and in turn STAT5A, which then can activate TNFSF11 expression [9];
FF PRL induces STAT5A-mediated expression of Glycam1 [11];
FF STAT5A binds to the GAS2-GAS1 elements as homotetramer [11];
FF STAT5A activates Socs3 promoter [12];
FF STAT5 up-regulates the transcript levels of target genes through at least two mechanisms, one through direct binding and activation and one through down-regulation of transcriptional repressors such as Gfi-1B T06585 [12];
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IN T00335 GR; mouse, Mus musculus.
IN T05076 GR; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T00944 STAT5B; mouse, Mus musculus.
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MX M00457 V$STAT5A_01.
MX M00460 V$STAT5A_02.
MX M00493 V$STAT5A_03.
MX M00499 V$STAT5A_04.
MX M07311 V$STAT5A_Q4.
MX M01890 V$STAT5A_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
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BS R17090.
BS R14619.
BS R14236.
BS R14614.
BS R11115.
BS R24153.
BS R11154.
BS R11155.
BS R15744.
BS R15839.
BS R25764.
BS R59492.
BS R59494.
BS R59495.
BS R38340.
BS R17078.
BS R17079.
BS R61629.
BS R61632.
BS R61634.
BS R03322.
BS R04917.
BS R15743.
BS R19622.
BS R04650.
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DR TRANSPATH: MO000013127.
DR TRANSCOMPEL: C00298.
DR TRANSCOMPEL: C00312.
DR TRANSCOMPEL: C00313.
DR TRANSCOMPEL: C00424.
DR TRANSCOMPEL: C00426.
DR UniProtKB: P42230;
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RN [1]; RE0003483.
RX PUBMED: 7760829.
RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N.
RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis
RL Mol. Cell. Biol. 15:3336-3343 (1995).
RN [2]; RE0003485.
RX PUBMED: 7537213.
RA Azam M., Erdjument-Bromage H., Kreider B. L., Xia M., Quelle F., Basu R., Saris C., Tempst P., Ihle J. N., Schindler C.
RT Interleukin-3 signals through multiple isoforms of Stat5
RL EMBO J. 14:1402-1411 (1995).
RN [3]; RE0003486.
RX PUBMED: 7720707.
RA Mui A. L.-F., Wakao H., OFarrell A.-M., Harada N., Miyajima A.
RT Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
RL EMBO J. 14:1166-1175 (1995).
RN [4]; RE0006063.
RX PUBMED: 9009201.
RA Liu X., Robinson G. W., Wagner K.-U., Garrett L., Wynshaw-Boris A., Hennighausen L.
RT Stat5a is mandatory for adult mammary gland development and lactogenesis
RL Genes Dev. 11:179-186 (1997).
RN [5]; RE0010933.
RX PUBMED: 7568026.
RA Liu X., Robinson G. W., Gouilleux F., Groner B., Hennighausen L.
RT Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
RL Proc. Natl. Acad. Sci. USA 92:8831-8835 (1995).
RN [6]; RE0023360.
RX PUBMED: 8830676.
RA Wehinger J., Gouilleux F., Groner B., Finke J., Mertelsmann R., Weber-Nordt R. M.
RT IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes.
RL FEBS Lett. 394:365-370 (1996).
RN [7]; RE0024707.
RX PUBMED: 12060651.
RA Chughtai N., Schimchowitsch S., Lebrun J. J., Ali S.
RT Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells.
RL J. Biol. Chem. 277:31107-31114 (2002).
RN [8]; RE0024927.
RX PUBMED: 14597631.
RA Gewinner C., Hart G., Zachara N., Cole R., Beisenherz-Huss C., Groner B.
RT The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.
RL J. Biol. Chem. 279:3563-3572 (2004).
RN [9]; RE0024929.
RX PUBMED: 12952963.
RA Srivastava S., Matsuda M., Hou Z., Bailey J. P., Kitazawa R., Herbst M. P., Horseman N. D.
RT Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells.
RL J. Biol. Chem. 278:46171-46178 (2003).
RN [10]; RE0024933.
RX PUBMED: 14645506.
RA Magne S., Caron S., Charon M., Rouyez M. C., Dusanter-Fourt I.
RT STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.
RL Mol. Cell. Biol. 23:8934-8945 (2003).
RN [11]; RE0024936.
RX PUBMED: 12869589.
RA Hou Z., Srivastava S., Mistry M. J., Herbst M. P., Bailey J. P., Horseman N. D.
RT Two tandemly linked interferon-gamma-activated sequence elements in the promoter of glycosylation-dependent cell adhesion molecule 1 gene synergistically respond to prolactin in mouse mammary epithelial cells.
RL Mol. Endocrinol. 17:1910-1920 (2003).
RN [12]; RE0035255.
RX PUBMED: 11696536.
RA Jegalian A. G., Wu H.
RT Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
RL J. Biol. Chem. 277:2345-2352 (2002).
RN [13]; RE0039373.
RX PUBMED: 11413148.
RA Mahajan S., Vassilev A., Sun N., Ozer Z., Mao C., Uckun F. M.
RT Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells
RL J. Biol. Chem. 276:31216-28 (2001).
RN [14]; RE0041352.
RX PUBMED: 11254359.
RA Ilan N., Cheung L., Miller S., Mohsenin A., Tucker A., Madri J. A.
RT Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse
RL Dev. Biol. 232:219-32 (2001).
RN [15]; RE0042412.
RX PUBMED: 9528750.
RA Cella N., Groner B., Hynes N. E.
RT Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells
RL Mol. Cell. Biol. 18:1783-92 (1998).
RN [16]; RE0050406.
RX PUBMED: 16886906.
RA Starzynski R. R., Goncalves A. S., Muzeau F., Tyrolczyk Z., Smuda E., Drapier J. C., Beaumont C., Lipinski P.
RT STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.
RL Biochem. J. 400:367-375 (2006).
RN [17]; RE0051792.
RX PUBMED: 17519353.
RA Sakamoto K., Creamer B. A., Triplett A. A., Wagner K. U.
RT The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
RL Mol. Endocrinol. 21:1877-1892 (2007).
RN [18]; RE0051810.
RX PUBMED: 9516478.
RA Ali S., Ali S.
RT Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways.
RL J. Biol. Chem. 273:7709-7716 (1998).
RN [19]; RE0051815.
RX PUBMED: 11133161.
RA Gallego M. I., Binart N., Robinson G. W., Okagaki R., Coschigano K. T., Perry J., Kopchick J. J., Oka T., Kelly P. A., Hennighausen L.
RT Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
RL Dev. Biol. 229:163-175 (2001).
RN [20]; RE0051994.
RX PUBMED: 11981045.
RA Nevalainen M. T., Xie J., Bubendorf L., Wagner K. U., Rui H.
RT Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium.
RL Mol. Endocrinol. 16:1108-1124 (2002).
RN [21]; RE0052366.
RX PUBMED: 16754961.
RA Akhtar N., Streuli C. H.
RT Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia.
RL J. Cell Biol. 173:781-793 (2006).
RN [22]; RE0052384.
RX PUBMED: 16469767.
RA Harris J., Stanford P. M., Sutherland K., Oakes S. R., Naylor M. J., Robertson F. G., Blazek K. D., Kazlauskas M., Hilton H. N., Wittlin S., Alexander W. S., Lindeman G. J., Visvader J. E., Ormandy C. J.
RT Socs2 and elf5 mediate prolactin-induced mammary gland development.
RL Mol. Endocrinol. 20:1177-1187 (2006).
RN [23]; RE0052420.
RX PUBMED: 8961260.
RA Liu X., Robinson G. W., Hennighausen L.
RT Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.
RL Mol. Endocrinol. 10:1496-1506 (1996).
RN [24]; RE0052474.
RX PUBMED: 14646587.
RA Joung Y. H., Park J. H., Park T., Lee C. S., Kim O. H., Ye S. K., Yang U. M., Lee K. J., Yang Y. M.
RT Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells.
RL Exp. Mol. Med. 35:350-357 (2003).
RN [25]; RE0052684.
RX PUBMED: 8906870.
RA Philp J. A., Burdon T. G., Watson C. J.
RT Differential activation of STATs 3 and 5 during mammary gland development.
RL FEBS Lett. 396:77-80 (1996).
RN [26]; RE0052744.
RX PUBMED: 9292509.
RA Feldman G. M., Rosenthal L. A., Liu X., Hayes M. P., Wynshaw-Boris A., Leonard W. J., Hennighausen L., Finbloom D. S.
RT STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression.
RL Blood 90:1768-1776 (1997).
RN [27]; RE0052792.
RX PUBMED: 11564778.
RA Kawashima T., Murata K., Akira S., Tonozuka Y., Minoshima Y., Feng S., Kumagai H., Tsuruga H., Ikeda Y., Asano S., Nosaka T., Kitamura T.
RT STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65.
RL J. Immunol. 167:3652-3660 (2001).
RN [28]; RE0053210.
RX PUBMED: 9630227.
RA Teglund S., McKay C., Schuetz E., van Deursen J. M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., Ihle J. N.
RT Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.
RL Cell 93:841-850 (1998).
RN [29]; RE0054272.
RX PUBMED: 11604235.
RA Yamashita H., Nevalainen M. T., Xu J., LeBaron M. J., Wagner K. U., Erwin R. A., Harmon J. M., Hennighausen L., Kirken R. A., Rui H.
RT Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.
RL Mol. Cell. Endocrinol. 183:151-163 (2001).
RN [30]; RE0064130.
RX PUBMED: 18362173.
RA Flex E., Petrangeli V., Stella L., Chiaretti S., Hornakova T., Knoops L., Ariola C., Fodale V., Clappier E., Paoloni F., Martinelli S., Fragale A., Sanchez M., Tavolaro S., Messina M., Cazzaniga G., Camera A., Pizzolo G., Tornesello A., Vignetti M., Battistini A., Cave H., Gelb B. D., Renauld J. C., Biondi A., Constantinescu S. N., Foa R., Tartaglia M.
RT Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.
RL J. Exp. Med. 205:751-758 (2008).
RN [31]; RE0064740.
RX PUBMED: 17638849.
RA Ramshaw H. S., Guthridge M. A., Stomski F. C., Barry E. F., Ooms L., Mitchell C. A., Begley C. G., Lopez A. F.
RT The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
RL Blood 110:3582-3590 (2007).
RN [32]; RE0064920.
RX PUBMED: 19109256.
RA Chen J., Olsen J., Ford S., Mirza S., Walker A., Murphy J. M., Young I. G.
RT A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.
RL J. Biol. Chem. 284:5763-5773 (2009).
RN [33]; RE0065726.
RX PUBMED: 16698929.
RA Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B. M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J.
RT Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
RL Proc. Natl. Acad. Sci. USA 103:8137-8142 (2006).
RN [34]; RE0065994.
RX PUBMED: 15166220.
RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C.
RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.
RL J. Biol. Chem. 279:32269-32274 (2004).
RN [35]; RE0067594.
RX PUBMED: 16293640.
RA Clarkson R. W., Boland M. P., Kritikou E. A., Lee J. M., Freeman T. C., Tiffen P. G., Watson C. J.
RT The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.
RL Mol. Endocrinol. 20:675-685 (2006).
RN [36]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [37]; RE0072000.
RX PUBMED: 21262971.
RA Arora D., Stopp S., Bohmer S. A., Schons J., Godfrey R., Masson K., Razumovskaya E., Ronnstrand L., Tanzer S., Bauer R., Bohmer F. D., Muller J. P.
RT Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
RL J. Biol. Chem. 286:10918-10929 (2011).
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