TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06585 XX ID T06585 XX DT 10.05.2005 (created); elf. DT 20.08.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA gfi1b XX SY Gfi-1B; GFI1B; Growth factor independence-1B; growth factor independent 1B. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G018220 Gfi1b. XX CL C0001; CH; XX CP high in erythroid precursors and megakaryocytes, high in bone marrow, thymus and spleen [1]; very high in bone marrow and spleen [5] [1] [5]. CN appears to be largely absent from T-cells [1]; granulocytes, myelocytes [4] [1] [4]. EX bone marrow,,,adult; very high; Northern blot; total RNA; [5]. EX spleen,,,adult; very high; Northern blot; total RNA; [5]. XX FF SNAG repression domain, transcriptional repressor [2]; FF gfi1b may also regulate Gfi1 G009648 through the same sequences used by Gfi1 T06593 [2]; FF gfi1b is an additive, distance-independent, active transcriptional repressor which functions by binding to the same DNA sequences as Gfi1 T01921 [5]; FF the gfi1b repressor is involved in regulating the process of hematopoietic cell differentiation and in lymphoid cell oncogenesis [5]; FF the differentiation controlling function and perhaps the oncogenic function may depend at least partially on the ability of the protein to repress the expression of the cyclin-dependent kinase inhibitor p21waf1 G005919 [5]; FF role in stem cell differentiation and erythropoiesis [3]; FF overexpressing gfi1b repressed Socs1 R17076R17077 and Socs3 R17080 but apparently not Socs2 G006744 promoter activity, which showed no effect [6]; XX IN T14315 AML1; Mammalia. IN T10541 E2A; mouse, Mus musculus. IN T02334 FOG; mouse, Mus musculus. IN T00305 GATA-1; mouse, Mus musculus. IN T10217 GATA-1; Mammalia. IN T16151 Tal-1; mouse, Mus musculus. XX MX M01058 V$GFI1B_01. MX M07097 V$GFI1B_02. MX M03825 V$GFI1B_Q6. MX M01067 V$GFI1_Q6. XX BS R16908. BS R16906. BS R16907. BS R16698. XX DR TRANSPATH: MO000054415. DR UniProtKB: O70237; O70237_MOUSE. XX RN [1]; RE0035152. RX PUBMED: 15718298. RA Vassen L., Fiolka K., Mahlmann S., Moroy T. RT Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b. RL Nucleic Acids Res. 33:987-998 (2005). RN [2]; RE0035163. RX PUBMED: 15131254. RA Doan L. L., Porter S. D., Duan Z., Flubacher M. M., Montoya D., Tsichlis P. N., Horwitz M., Gilks C. B., Grimes H. L. RT Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. RL Nucleic Acids Res. 32:2508-2519 (2004). RN [3]; RE0035164. RX PUBMED: 12721361. RA Duan Z., Horwitz M. RT Targets of the transcriptional repressor oncoprotein Gfi-1. RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003). RN [4]; RE0035165. RX PUBMED: 15618011. RA Moroy T. RT The zinc finger transcription factor Growth factor independence 1 (Gfi1). RL Int. J. Biochem. Cell Biol. 37:541-546 (2005). RN [5]; RE0035205. RX PUBMED: 9566867. RA Tong B., Grimes H. L., Yang T. Y., Bear S. E., Qin Z., Du K., El-Deiry W. S., Tsichlis P. N. RT The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. RL Mol. Cell. Biol. 18:2462-2473 (1998). RN [6]; RE0035255. RX PUBMED: 11696536. RA Jegalian A. G., Wu H. RT Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin. RL J. Biol. Chem. 277:2345-2352 (2002). RN [7]; RE0049146. RX PUBMED: 16287841. RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C. RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. RL Mol. Cell. Biol. 25:10235-10250 (2005). XX //