TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01921 XX ID T01921 XX DT 25.09.1996 (created); ewi. DT 25.07.2007 (updated); apk. CO Copyright (C), QIAGEN. XX FA Gfi1 XX SY GFI1; growth factor independence 1; growth factor independent 1. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009648 Gfi1. XX HO pag-3 (C. elegans) T03543. XX CL C0001; CH; XX SF contains novel zinc-finger motif; XX CP adult thymus, splenocytes, spleen, testis, bone marrow, lymphopoietic thymus [1]. XX FF repressor [1]; FF Gfi1 zinc fingers 3, 4 and 5 are required whereas zinc fingers 1, 2 and 6 are dispensable for DNA binding [1]; FF SNAG 20 amino-acid, N-terminal repression domain [3]; FF position- and orientation-independent active transcriptional repressor [5]; FF Gfi1 releases cells from a G1 block induced by IL-2 withdrawal and is targeted by proviral integration in a number of tumor systems [5]; FF role in stem cell differentiation and in granulocytic differentiation [4]; XX MX M00250 V$GFI1_01. MX M01067 V$GFI1_Q6. MX M02010 V$GFI1_Q6_01. XX BS R16972. BS R16974. BS R04921. BS R16772. BS R16773. BS R17057. XX DR TRANSPATH: MO000026035. DR UniProtKB: Q07120; XX RN [1]; RE0004467. RX PUBMED: 8754800. RA Zweidler-McKay P. A., Grimes H. L., Flubacher M. M., Tsichlis P. N. RT Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor RL Mol. Cell. Biol. 16:4024-4034 (1996). RN [2]; RE0014758. RX PUBMED: 9169852. RA Jia Y., Xie G., McDermott J. B., Aamodt E. RT The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1 RL Development 124:2063-2073 (1997). RN [3]; RE0035163. RX PUBMED: 15131254. RA Doan L. L., Porter S. D., Duan Z., Flubacher M. M., Montoya D., Tsichlis P. N., Horwitz M., Gilks C. B., Grimes H. L. RT Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. RL Nucleic Acids Res. 32:2508-2519 (2004). RN [4]; RE0035164. RX PUBMED: 12721361. RA Duan Z., Horwitz M. RT Targets of the transcriptional repressor oncoprotein Gfi-1. RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003). RN [5]; RE0035172. RX PUBMED: 8887656. RA Grimes H. L., Chan T. O., Zweidler-McKay P. A., Tong B., Tsichlis P. N. RT The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. RL Mol. Cell. Biol. 16:6263-6272 (1996). XX //