AC T03543
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ID T03543
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DT 10.07.2000 (created); rio.
CO Copyright (C), QIAGEN.
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FA pag-3
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SY pattern of gene expression of mec-7 3.
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OS Caenorhabditis elegans
OC eukaryota; animalia; metazoa; nematoda; secernentea; rhabditia; rhabditida; rhabditina; rhabditoidea; rhabditidae
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HO Gfi-1 (rat) T01921.
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CL C0001; CH.
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SZ 336 AA; 38.2 kDa (cDNA) (calc.).
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SQ MSTEHVSNVYSVESLLSNVEKSSVSPTESIEDRNEFMITEDVMSSWQRMAATISLQQKLL
SQ MMQQTMPRPPPVNILGNFPFGFLNAPMFWQQYLRSMAMGIIPQNPESPSASVWNRTPTPP
SQ VEIKPFHCQKCTKLFSTIAALEQHQQVHVSDKQFECKQCGKTFKRSSTLSTHLLIHSDTR
SQ PYPCEYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGFKPFAC
SQ DVCGRTFQRKVDRRRHRESHHPGHPEECVSASQISSDLSPKGYMTPPTSNGYLDSSDEFL
SQ NVFRLPAELLAIKAEMGEEMEEADDEEEKVLNLSVS
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SC translated from EMBL #U63996
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FT 126 148 
PF00096; zf-C2H2.
FT 126 148 
SM00355; c2h2final6.
FT 126 153 
PS50157; ZINC_FINGER_C2H2_2.
FT 154 176 
PF00096; zf-C2H2.
FT 154 176 
SM00355; c2h2final6.
FT 154 181 
PS50157; ZINC_FINGER_C2H2_2.
FT 182 204 
PF00096; zf-C2H2.
FT 182 204 
SM00355; c2h2final6.
FT 182 209 
PS50157; ZINC_FINGER_C2H2_2.
FT 210 232 
PF00096; zf-C2H2.
FT 210 232 SM00355; c2h2final6.
FT 210 237 PS50157; ZINC_FINGER_C2H2_2.
FT 238 260 PF00096; zf-C2H2.
FT 238 260 SM00355; c2h2final6.
FT 238 265 PS50157; ZINC_FINGER_C2H2_2.
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SF pag-3 mutants display misexpression of touch neuron genes in the BDU neurons and have motility defects (lethargic behavior, reverse kinker) [3];
SF chromosomal location: right arm of the X-chromosome between unc-3 and und unc-7 [2];
SF high similarity in sequence, structure, expression and function to pag-3 T03544 of C. briggsae [1];
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CP (embryos, L1-L3 larvae:) BDU neurons, all 6 touch neurons, 11 of 12 VA motor neurons, all 11 VB motor neurons, 2 AVF interneurons [2].
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FF pag-3 may negatively regulate the expression of mec-2, -4, -7, -9 and its own expression in touch neurons [2];
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DR TRANSPATH: MO000027477.
DR EMBL: U63996;
DR EMBL: Z83227;
DR UniProtKB: G5EDE1;
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RN [1]; RE0014756.
RX PUBMED: 10675614.
RA Aamodt E., Shen L., Marra M., Schein J., Rose B., McDermott J. B.
RT Conservation of sequence and function of the pag-3 genes from C. elegans and C. briggsae
RL Gene 243:67-74 (2000).
RN [2]; RE0014758.
RX PUBMED: 9169852.
RA Jia Y., Xie G., McDermott J. B., Aamodt E.
RT The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1
RL Development 124:2063-2073 (1997).
RN [3]; RE0014760.
RX PUBMED: 8770591.
RA Jia Y., Xie G., Aamodt E.
RT pag-3, a Caenorhabditis elegans gene involved in touch neuron gene expression and coordinated movement
RL Genetics 142:141-147 (1996).
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