
AC   T10541
XX
ID   T10541
XX
DT   28.08.2002 (created); spi.
DT   19.04.2016 (updated); nes.
CO   Copyright (C), QIAGEN.
XX
FA   E2A
XX
SY   a1; ALF2; E12; E2A; E47; ME2; Pan1; PAN2; TCF3; Tcfe2a; transcription factor E2a; VDIR.
XX
OS   mouse, Mus musculus
OC   eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE   G005705 Tcf3.
XX
CL   C0010; bHLH; 1.2.1.0.1.
XX
IN   T00305 GATA-1; mouse, Mus musculus.
IN   T06585 gfi1b; mouse, Mus musculus.
IN   T09638 Hand2; mouse, Mus musculus.
XX
MX   M00693 V$E12_Q6.
MX   M00804 V$E2A_Q2.
MX   M00973 V$E2A_Q6.
MX   M02088 V$E2A_Q6_01.
MX   M07353 V$E2A_Q6_02.
MX   M00002 V$E47_01.
MX   M00071 V$E47_02.
MX   M07477 V$E47_05.
MX   M01034 V$EBOX_Q6_01.
MX   M00222 V$HAND1E47_01.
MX   M00929 V$MYOD_Q6_01.
MX   M00066 V$TAL1ALPHAE47_01.
MX   M00065 V$TAL1BETAE47_01.
MX   M02823 V$TCFE2A_03.
MX   M02927 V$TCFE2A_04.
XX
BS   R36488.
BS   R70639.
BS   R70650.
BS   R70651.
BS   R70652.
BS   R70653.
BS   R70654.
BS   R70655.
BS   R70656.
BS   R70657.
BS   R70658.
BS   R70659.
BS   R70660.
BS   R70661.
BS   R38867.
BS   R36489.
BS   R28952.
BS   R38766.
BS   R72698.
BS   R72828.
BS   R72830.
BS   R60665.
BS   R72762.
BS   R73037.
BS   R00860.
BS   R26276.
BS   R30631.
BS   R33394.
BS   R26767.
BS   R63063.
BS   R26270.
BS   R26272.
XX
DR   TRANSPATH: MO000032519.
DR   UniProtKB: P15806;
XX
RN   [1]; RE0035992.
RX   PUBMED: 14592976.
RA   Nie L., Xu M., Vladimirova A., Sun X. H.
RT   Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
RL   EMBO J. 22:5780-5792 (2003).
RN   [2]; RE0048975.
RX   PUBMED: 11812799.
RA   Dai Y. S., Cserjesi P.
RT   The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.
RL   J. Biol. Chem. 277:12604-12612 (2002).
RN   [3]; RE0049144.
RX   PUBMED: 15456869.
RA   Huang Z., Nie L., Xu M., Sun X. H.
RT   Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.
RL   Mol. Cell. Biol. 24:8951-8962 (2004).
RN   [4]; RE0049146.
RX   PUBMED: 16287841.
RA   Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C.
RT   ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
RL   Mol. Cell. Biol. 25:10235-10250 (2005).
RN   [5]; RE0049178.
RX   PUBMED: 15314159.
RA   Schlaeger T. M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S. H., Vyas P., Porcher C.
RT   Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
RL   Mol. Cell. Biol. 24:7491-7502 (2004).
XX
//