AC T02482
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ID T02482
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DT 15.06.1998 (created); ewi.
DT 03.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TIF2
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SY glucocorticoid receptor interacting protein 1; GRIP1; NCoA-2; NCOA2; nuclear receptor coactivator 2; SRC-2; TIF2; transcriptional intermediary factor 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005150 Ncoa2.
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CL C0010; bHLH; 1.2.5.3.2.
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SF interacts with the hormone-binding domain of nuclear receptors in a ligand-dependent manner [1];
SF NR-box 2 and 3 important for interaction with ERR3 T04644 [3];
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FF coactivator specifically of nuclear receptor AF-2 function [2];
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IN T01795 AhR; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T00041 AR; mouse, Mus musculus.
IN T01797 arnt; mouse, Mus musculus.
IN T15118 CBP; Mammalia.
IN T00259 ER-alpha; mouse, Mus musculus.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09602 ER; Mammalia.
IN T04644 ERR3-isoform1; mouse, Mus musculus.
IN T04647 ERR3-isoform2; mouse, Mus musculus.
IN T01686 GCN5; human, Homo sapiens.
IN T00335 GR; mouse, Mus musculus.
IN T00511 MR; rat, Rattus norvegicus.
IN T01327 NR1B1; mouse, Mus musculus.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T08551 SF-1; mouse, Mus musculus.
IN T01173 T3R-alpha2; mouse, Mus musculus.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T00883 VDR; mouse, Mus musculus.
IN T05150 ZAC-1b; mouse, Mus musculus.
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DR TRANSPATH: MO000026463.
DR UniProtKB: Q61026; NCOA2_MOUSE.
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RN [1]; RE0006903.
RX PUBMED: 8643509.
RA Hong H., Kohli K., Trivedi A., Johnsson D. L., Stallcup M. R.
RT GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
RL Proc. Natl. Acad. Sci. USA 93:4948-4952 (1996).
RN [2]; RE0006906.
RX PUBMED: 9111344.
RA Hong H., Kohli K., Garabedian M. J., Stallcup M. R.
RT GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
RL Mol. Cell. Biol. 17:2735-2744 (1997).
RN [3]; RE0016449.
RX PUBMED: 10428842.
RA Hong H., Yang L., Stallcup M. R.
RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
RL J. Biol. Chem. 274:22618-22626 (1999).
RN [4]; RE0030488.
RX PUBMED: 12507421.
RA Picard F., Gehin M., Annicotte J., Rocchi S., Champy M. F., O'Malley B. W., Chambon P., Auwerx J.
RT SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
RL Cell 111:931-41 (2002).
RN [5]; RE0035771.
RX PUBMED: 10809234.
RA Anafi M., Yang Y. F., Barlev N. A., Govindan M. V., Berger S. L., Butt T. R., Walfish P. G.
RT GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor.
RL Mol. Endocrinol. 14:718-732 (2000).
RN [6]; RE0055872.
RX PUBMED: 17882261.
RA Yue W. W., Hassler M., Roe S. M., Thompson-Vale V., Pearl L. H.
RT Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.
RL EMBO J. 26:4402-4412 (2007).
RN [7]; RE0065548.
RX PUBMED: 19574399.
RA Chen J., An B. S., Cheng L., Hammond G. L., Leung P. C.
RT Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
RL Endocrinology 150:4583-4593 (2009).
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