AC T05150
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ID T05150
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DT 18.06.2002 (created); mas.
DT 21.10.2008 (updated); jag.
CO Copyright (C), QIAGEN.
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FA ZAC-1b
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SY DJ468K18.3; lost on transformation; LOT-1; LOT1; PLAGL1; Pleiomorphic Adenoma Gene-like 1; Zac 1; Zinc Finger Protein DJ468K18.3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004490 Plagl1.
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CL C0034; zin.
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SZ 704 AA; 79.2 kDa (calc.), >100 kDa (SDS) [2]
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SQ MAPFRCQKCGKSFVTLEKFTIHNYSHSRERPFKCSKAECGKAFVSKYKLMRHMATHSPQK
SQ IHQCTHCEKTFNRKDHLKNHLQTHDPNKISYACDDCGKKYHTMLGYKRHLALHSASNGDL
SQ TCGVCTLELGSTEVLLDHLKSHAEEKANQAPREKKYQCDHCDRCFYTRKDVRRHLVVHTG
SQ CKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMQENMQAGDYQSNFQLIAPSTSFQIKVDP
SQ MPPFQLGAAPENGLDGGLPPEVHGLVLAAPEEAPQPMPPLEPLEPLEPLEPLEPMQSLEP
SQ LQPLEPMQPLEPMQPLEPMQPLEPLEPLEPMQPLEPMQPLEPMQPMLPMQPMQPMQPMQP
SQ MLPMQPMLPMQPMQPMQPMLPMPEPSFTLHPGVVPTSPPPIILQEHKYNPVPTSYAPFVG
SQ MPVKADGKAFCNVGFFEEFPLQEPQAPLKFNPCFEMPMEGFGKVTLSKELLVDAVNIAIP
SQ ASLEISSLLGFWQLPPPTPQNGFVNSTIPVGPGEPLPHRITCLAQQQPPPLPPPPPLPLP
SQ QPLPVPQPLPQPQMQPQFQLQIQPQMQPQMQLQPLQLQLPQLLPQLQPQQQPDPEPEPEP
SQ EPEPEPEPEPEPEPEPEPEPEPEPEEEQEEAEEEAEEGAEEGAEPEAQAEEEEEEEEAEE
SQ PQPEEAQIAVSAVNLGQPPLPPTPHIFTAGSNTAILPHFHHAFR
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SC translated from EMBL #AF147785
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FT 4 26 
PF00096; zf-C2H2.
FT 4 26 
SM00355; c2h2final6.
FT 4 31 
PS50157; ZINC_FINGER_C2H2_2.
FT 32 56 
PF00096; zf-C2H2.
FT 32 56 
SM00355; c2h2final6.
FT 32 61 
PS50157; ZINC_FINGER_C2H2_2.
FT 62 84 
PF00096; zf-C2H2.
FT 62 84 
SM00355; c2h2final6.
FT 62 89 
PS50157; ZINC_FINGER_C2H2_2.
FT 91 113 
PF00096; zf-C2H2.
FT 91 113 SM00355; c2h2final6.
FT 91 118 PS50157; ZINC_FINGER_C2H2_2.
FT 120 142 SM00355; c2h2final6.
FT 156 178 PF00096; zf-C2H2.
FT 156 178 SM00355; c2h2final6.
FT 156 183 PS50157; ZINC_FINGER_C2H2_2.
FT 184 207 PF00096; zf-C2H2.
FT 184 207 SM00355; c2h2final6.
FT 184 212 PS50157; ZINC_FINGER_C2H2_2.
FT 280 383 missing in human ortholog T05149 [1].
FT 280 383 prolin-repeats [1].
FT 527 653 glutamate-clusters [1].
FT 527 653 missing in human ortholog T05149 [1].
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SF protein sequence (704 aa) longer than sequence of human ortholog T05149 (463 aa) with two major differences: presence of a Proline-repeat (pos. 280-383) and a Glutamate-cluster (pos.527-653) [1];
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FF coactivator and corepressor for nuclear receptors (depends on type of nuclear receptor, promoter context, and cellular context) [2];
FF physical interaction with several nuclear receptors and coactivators shown [2];
FF enhances AR T00040 function synergistically with coactivator GRIP/TIF2 T02482 [2];
FF either coactivation or repression of ER T00261 function in dependence of analyzed promoter (transcriptional repression with MMTV-ERE and activation with EREII-LUC/GL45 reporter gene) [2];
FF normally enhances GRIP1/TIF2 T02482 and CBP T02214 activity;
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IN T00040 AR; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T15118 CBP; Mammalia.
IN T00261 ER-alpha; human, Homo sapiens.
IN T00511 MR; rat, Rattus norvegicus.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T02482 TIF2; mouse, Mus musculus.
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DR TRANSPATH: MO000032985.
DR EMBL: AF147785;
DR UniProtKB: Q9JLQ4;
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RN [1]; RE0017856.
RX PUBMED: 9671765.
RA Varrault A., Ciani E., Apiou F., Bilanges B., Hoffmann A., Pantaloni C., Bockaert J., Spengler D., Journot L.
RT hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
RL Proc. Natl. Acad. Sci. USA 95:8835-8840 (1998).
RN [2]; RE0017857.
RX PUBMED: 10669760.
RA Huang S. M., Stallcup M. R.
RT Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors
RL Mol. Cell. Biol. 20:1855-1867 (2000).
RN [3]; RE0054280.
RX PUBMED: 17336575.
RA Chang Y. L., Huang C. J., Chan J. Y., Liu P. Y., Chang H. P., Huang S. M.
RT Regulation of nuclear receptor and coactivator functions by the carboxyl terminus of ubiquitin-conjugating enzyme 9.
RL Int. J. Biochem. Cell Biol. 39:1035-1046 (2007).
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