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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T05149 XX ID T05149 XX DT 17.06.2002 (created); mas. DT 17.06.2013 (updated); mkl. CO Copyright (C), QIAGEN. XX FA ZAC-isoform1 XX SY DJ468K18.3; lost on transformation; LOT-1; LOT1; PLAGL1; Pleiomorphic Adenoma Gene-like 1; Zac 1; Zac Delta 2 Protein; Zinc Finger Protein DJ468K18.3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004489 PLAGL1; HGNC: PLAGL1. XX CL C0034; zin; 2.3.3.25.3.1. XX SZ 463 AA; 50.8 kDa (cDNA) (calc.). XX SQ MATFPCQLCGKTFLTLEKFTIHNYSHSRERPYKCVQPDCGKAFVSRYKLMRHMATHSPQK SQ SHQCAHCEKTFNRKDHLKNHLQTHDPNKMAFGCEECGKKYNTMLGYKRHLALHAASSGDL SQ TCGVCALELGSTEVLLDHLKAHAEEKPPSGTKEKKHQCDHCERCFYTRKDVRRHLVVHTG SQ CKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMKESLQTGDLLSTFHTISPSFQLKAAALP SQ PFPLGASAQNGLASSLPAEVHSLTLSPPEQAAQPMQPLPESLASLHPSVSPGSPPPPLPN SQ HKYNTTSTSYSPLASLPLKADTKGFCNISLFEDLPLQEPQSPQKLNPGFDLAKGNAGKVN SQ LPKELPADAVNLTIPASLDLSPLLGFWQLPPPATQNTFGNSTLALGPGESLPHRLSCLGQ SQ QQQEPPLAMGTVSLGQLPLPPIPHVFSAGTGSAILPHFHHAFR XX SC translated from EMBL #AJ006354 XX FT 4 26 PF00096; zf-C2H2. FT 4 26 SM00355; c2h2final6. FT 4 31 PS50157; ZINC_FINGER_C2H2_2. FT 32 56 PF00096; zf-C2H2. FT 32 56 SM00355; c2h2final6. FT 32 61 PS50157; ZINC_FINGER_C2H2_2. FT 62 84 PF00096; zf-C2H2. FT 62 84 SM00355; c2h2final6. FT 62 89 PS50157; ZINC_FINGER_C2H2_2. FT 91 113 PF00096; zf-C2H2. FT 91 113 SM00355; c2h2final6. FT 91 118 PS50157; ZINC_FINGER_C2H2_2. FT 120 142 SM00355; c2h2final6. FT 120 147 PS50157; ZINC_FINGER_C2H2_2. FT 156 178 PF00096; zf-C2H2. FT 156 178 SM00355; c2h2final6. FT 156 183 PS50157; ZINC_FINGER_C2H2_2. FT 184 207 PF00096; zf-C2H2. FT 184 207 SM00355; c2h2final6. FT 184 212 PS50157; ZINC_FINGER_C2H2_2. XX SF ZAC-isoform1 (EMBL #AJ006354) and LOT-1 (EMBL #U72621) are identical except in one residue at pos. 81 (L versus F); SF >55% amino acid identity in with mouse homolog T05150 between pos. 1 and 425; SF human protein sequence (463 aa) shorter than sequence of mouse ortholog T05150 (704 aa) with two major differences: a proline-repeat (pos. 278-279: 104 aa) and Glutamate-cluster (pos.422-423: 127 aa) missing compared to mouse homolog [2]; XX EX adrenal gland (right and left),,,adult; very high; Northern blot; RNA (undefined); [2]. EX amygdaloid body,,,adult; very low; Northern blot; RNA (undefined); [2]. EX aorta,,,adult; high; Northern blot; RNA (undefined); [2]. EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; RNA (undefined); [2]. EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; RNA (undefined); [2]. EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; RNA (undefined); [2]. EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; RNA (undefined); [2]. EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; RNA (undefined); [2]. EX bone marrow,,,adult; medium; Northern blot; RNA (undefined); [2]. EX brain,,,adult; low; Northern blot; RNA (undefined); [2]. EX caudate nucleus,,,adult; very low; Northern blot; RNA (undefined); [2]. EX cerebellum,,,adult; very low; Northern blot; RNA (undefined); [2]. EX cerebral cortex of cerebral hemisphere,,,adult; low; Northern blot; RNA (undefined); [2]. EX cerebral cortex,,,adult; low; Northern blot; RNA (undefined); [2]. EX colon,,,adult; high; Northern blot; RNA (undefined); [2]. EX frontal lobe of medial and inferior surfaces,,,adult; very low; Northern blot; RNA (undefined); [2]. EX frontal lobe of superolateral face,,,adult; very low; Northern blot; RNA (undefined); [2]. EX heart,,,adult; high; Northern blot; RNA (undefined); [2]. EX hippocampus,,,adult; very low; Northern blot; RNA (undefined); [2]. EX kidney (right and left),,,adult; very high; Northern blot; RNA (undefined); [2]. EX liver,,,adult; low; Northern blot; RNA (undefined); [2]. EX lung (right and left),,,adult; high; Northern blot; RNA (undefined); [2]. EX lymph node,,,adult; high; Northern blot; RNA (undefined); [2]. EX major salivary glands,,,adult; medium; Northern blot; RNA (undefined); [2]. EX mammary gland,,,adult; high; Northern blot; RNA (undefined); [2]. EX minor salivary glands,,,adult; medium; Northern blot; RNA (undefined); [2]. EX muscles,,,adult; low; Northern blot; RNA (undefined); [2]. EX myelencephalon,,,adult; very low; Northern blot; RNA (undefined); [2]. EX occipital lobe of medial and inferior surfaces,,,adult; low; Northern blot; RNA (undefined); [2]. EX occipital lobe of superolateral face,,,adult; low; Northern blot; RNA (undefined); [2]. EX ovary (right and left),,,adult; high; Northern blot; RNA (undefined); [2]. EX pancreas,,,adult; high; Northern blot; RNA (undefined); [2]. EX pituitary gland of diencephalon,,,adult; very high; Northern blot; RNA (undefined); [2]. EX placenta,,,adult; very high; Northern blot; RNA (undefined); [2]. EX prostate gland,,,adult; high; Northern blot; RNA (undefined); [2]. EX putamen,,,adult; very low; Northern blot; RNA (undefined); [2]. EX small intestine,,,adult; high; Northern blot; RNA (undefined); [2]. EX spinal cord,,,adult; low; Northern blot; RNA (undefined); [2]. EX spleen,,,adult; high; Northern blot; RNA (undefined); [2]. EX stomach,,,adult; high; Northern blot; RNA (undefined); [2]. EX substantia nigra,,,adult; very low; Northern blot; RNA (undefined); [2]. EX subthalamic nucleus,,,adult; very low; Northern blot; RNA (undefined); [2]. EX temporal lobe of medial and inferior surfaces,,,adult; very low; Northern blot; RNA (undefined); [2]. EX temporal lobe of superolateral face,,,adult; very low; Northern blot; RNA (undefined); [2]. EX testis (right and left),,,adult; medium; Northern blot; RNA (undefined); [2]. EX thalamus,,,adult; low; Northern blot; RNA (undefined); [2]. EX thymus,,,adult; medium; Northern blot; RNA (undefined); [2]. EX thyroid gland,,,adult; high; Northern blot; RNA (undefined); [2]. EX trachea,,,adult; high; Northern blot; RNA (undefined); [2]. EX urinary bladder,,,adult; high; Northern blot; RNA (undefined); [2]. EX uterus,,,adult; high; Northern blot; RNA (undefined); [2]. XX FF activator (in transactivation experiments) [2]; FF can induce cell cycle arrest in G1 (in SaOS-2 cell) [2]; FF antiproliferative: can inhibit growth of tumor cells (in SaOS-2 cells) and good candidate for tumor suppressor, intracellular location: mainly in cell nucleus (of SaOS-2 cells) [2] [3]; FF can induce apoptosis (of SaOS2-cells) [2]; FF expression seems to be primarily mediated via EGF receptor or a related pathway [4]; XX IN T23091 p300; Mammalia. XX BS R12715. XX DR TRANSPATH: MO000032984. DR EMBL: AJ006354; DR EMBL: U72621; DR UniProtKB: Q9UM63-1; XX RN [1]; RE0017855. RX PUBMED: 12031496. RA Rodriguez-Henche N., Jamen F., Leroy C., Bockaert J., Brabet P. RT Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1 RL Biochim. Biophys. Acta 1576:157-162 (2002). RN [2]; RE0017856. RX PUBMED: 9671765. RA Varrault A., Ciani E., Apiou F., Bilanges B., Hoffmann A., Pantaloni C., Bockaert J., Spengler D., Journot L. RT hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer RL Proc. Natl. Acad. Sci. USA 95:8835-8840 (1998). RN [3]; RE0017859. RX PUBMED: 9150364. RA Abdollahi A., Roberts D., Godwin A. K., Schultz D. C., Sonoda G., Testa J. R., Hamilton T. C. RT Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors RL Oncogene 14:1973-1979 (1997). RN [4]; RE0017860. RX PUBMED: 10597250. RA Abdollahi A., Bao R., Hamilton T. C. RT LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein RL Oncogene 18:6477-6487 (1999). RN [5]; RE0049195. RX PUBMED: 16809786. RA Hoffmann A., Barz T., Spengler D. RT Multitasking C2H2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity. RL Mol. Cell. Biol. 26:5544-5557 (2006). XX //