AC T00511
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ID T00511
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DT 26.01.1993 (created); hse.
DT 08.12.2011 (updated); pch.
CO Copyright (C), QIAGEN.
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FA MR
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SY MCR; mineralcorticoid receptor; mineralocorticoid receptor; mineralocorticosteroid receptor; MLR; MR; NR3C2; nuclear receptor subfamily 3, group C, member 2.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014466 Nr3c2.
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CL C0002; CC (rec); 2.1.1.1.2.
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SF the DBD exhibits 94% homology with that of GR [2];
SF binds glucocorticoids and mineralcorticoids with equal affinity [2];
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FF activator, may mediate mineralocorticoid as well as glucocorticoid-induced transcription [2];
FF mineralocorticoids (aldosterone) are the physiological ligand in tissues where glucocorticoids are modified to non-binding analogs by 11beta-hydroxysteroid dehydrogenase [4];
FF ether aminophosphoglycerides have been suggested to stabilize ligand binding, but to inhibit receptor activation [3];
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IN T00992 Hsp90; human, Homo sapiens.
IN T00511 MR; rat, Rattus norvegicus.
IN T02482 TIF2; mouse, Mus musculus.
IN T05150 ZAC-1b; mouse, Mus musculus.
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BS R02203.
BS R37435.
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DR TRANSPATH: MO000021450.
DR UniProtKB: P22199; MCR_RAT.
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RN [1]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [2]; RE0002637.
RX PUBMED: 3037703.
RA Arriza J. L., Weinberger C., Cerelli G., Glaser T. M., Handelin B. L., Housman D. E., Evans R. M.
RT Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
RL Science 237:268-275 (1987).
RN [3]; RE0003718.
RX PUBMED: 1310618.
RA Schulman G., Bodine P. V., Litwack G.
RT Modulators of the glucocorticoid receptor also regulate mineralocorticoid receptor function.
RL Biochemistry 31:1734-1741 (1992).
RN [4]; RE0003723.
RX PUBMED: 2845584.
RA Funder J. W., Pearce P. T., Smith R., Smith A.I.
RT Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
RL Science 242:583-585 (1988).
RN [5]; RE0003725.
RX PUBMED: 1646819.
RA Ikeda U., Hyman R., Smith T. W., Medford R. M.
RT Aldosterone-mediated regulation of Na+,K+-ATPase gene expression in adult and neonatal rat cardiocytes
RL J. Biol. Chem. 266:12058-12066 (1991).
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