AC T01797
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ID T01797
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DT 07.05.1996 (created); ewi.
DT 04.06.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA arnt
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SY Ah receptor nuclear translocator; Arnt; aryl hydrocarbon receptor nuclear translocator; HIF-1beta; hypoxia-inducible factor 1beta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005183 Arnt.
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CL C0010; bHLH; 1.2.5.2.1.
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SF the basic region contacts DNA, the HLH domain mediates dimerization [2];
SF the PAS domain reveals some homology to Drosophila melanogaster Per and Sim [1];
SF it augments hetero-, but not homodimerization and is essential for arnt function in vivo [2] [4];
SF arnt does not form homodimers [2];
SF in heterodimeric complexes with either AhR or Sim, arnt recognizes the 3'-half-site sequence GTG [1];
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CP (liver).
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FF promotes release of ligand-complexed AhR from hsp90 [3];
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IN T05429 AhR repressor-isoform1; mouse, Mus musculus.
IN T00018 AhR; mouse, Mus musculus.
IN T01795 AhR; human, Homo sapiens.
IN T04666 HIF-1alpha; mouse, Mus musculus.
IN T02719 HIF2A; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T19235 sim2; mouse, Mus musculus.
IN T00750 Sim; fruit fly, Drosophila melanogaster.
IN T04632 SRC-1; human, Homo sapiens.
IN T02482 TIF2; mouse, Mus musculus.
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MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M08868 V$ARNTLIKE_Q6.
MX M00236 V$ARNT_01.
MX M00539 V$ARNT_02.
MX M03812 V$ARNT_Q6.
MX M08800 V$ARNT_Q6_01.
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BS R13350.
BS R03219.
BS R40707.
BS R62189.
BS R00272.
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DR TRANSPATH: MO000025934.
DR UniProtKB: P53762;
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RN [1]; RE0003789.
RX PUBMED: 7592839.
RA Swanson H. I., Chan W. K., Bradfield C. A.
RT DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins
RL J. Biol. Chem. 270:26292-26302 (1995).
RN [2]; RE0004039.
RX PUBMED: 8065918.
RA Carver L. A., Hogenesch J. B., Bradfield C. A.
RT Tissue specific expression of the rat Ah-receptor and ARNT mRNAs
RL Nucleic Acids Res. 22:3038-3044 (1994).
RN [3]; RE0004050.
RX PUBMED: 8139547.
RA McGuire J., Whitelaw M., Pongratz I., Gustafsson J. A., Poellinger L.
RT A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor
RL Mol. Cell. Biol. 14:2438-2446 (1994).
RN [4]; RE0005820.
RX PUBMED: 7628454.
RA Lindebro M. C., Poellinger L., Whitelaw M. L.
RT Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex
RL EMBO J. 14:3528-3539 (1995).
RN [5]; RE0063464.
RX PUBMED: 16484282.
RA Metz R. P., Kwak H. I., Gustafson T., Laffin B., Porter W. W.
RT Differential transcriptional regulation by mouse single-minded 2s.
RL J. Biol. Chem. 281:10839-10848 (2006).
RN [6]; RE0066620.
RX PUBMED: 17826745.
RA Friedman E. R., Fan C. M.
RT Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.
RL Biochem. Biophys. Res. Commun. 363:113-118 (2007).
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