TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01797 XX ID T01797 XX DT 07.05.1996 (created); ewi. DT 04.06.2014 (updated); asv. CO Copyright (C), QIAGEN. XX FA arnt XX SY Ah receptor nuclear translocator; Arnt; aryl hydrocarbon receptor nuclear translocator; HIF-1beta; hypoxia-inducible factor 1beta. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005183 Arnt. XX CL C0010; bHLH; XX SF the basic region contacts DNA, the HLH domain mediates dimerization [2]; SF the PAS domain reveals some homology to Drosophila melanogaster Per and Sim [1]; SF it augments hetero-, but not homodimerization and is essential for arnt function in vivo [2] [4]; SF arnt does not form homodimers [2]; SF in heterodimeric complexes with either AhR or Sim, arnt recognizes the 3'-half-site sequence GTG [1]; XX CP (liver). XX FF promotes release of ligand-complexed AhR from hsp90 [3]; XX IN T05429 AhR repressor-isoform1; mouse, Mus musculus. IN T00018 AhR; mouse, Mus musculus. IN T01795 AhR; human, Homo sapiens. IN T04666 HIF-1alpha; mouse, Mus musculus. IN T02719 HIF2A; mouse, Mus musculus. IN T10542 p300; mouse, Mus musculus. IN T19235 sim2; mouse, Mus musculus. IN T00750 Sim; fruit fly, Drosophila melanogaster. IN T04632 SRC-1; human, Homo sapiens. IN T02482 TIF2; mouse, Mus musculus. XX MX M00235 V$AHRARNT_01. MX M00237 V$AHRARNT_02. MX M00976 V$AHRHIF_Q6. MX M08868 V$ARNTLIKE_Q6. MX M00236 V$ARNT_01. MX M00539 V$ARNT_02. MX M03812 V$ARNT_Q6. MX M08800 V$ARNT_Q6_01. XX BS R13350. BS R03219. BS R40707. BS R62189. BS R00272. XX DR TRANSPATH: MO000025934. DR UniProtKB: P53762; XX RN [1]; RE0003789. RX PUBMED: 7592839. RA Swanson H. I., Chan W. K., Bradfield C. A. RT DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins RL J. Biol. Chem. 270:26292-26302 (1995). RN [2]; RE0004039. RX PUBMED: 8065918. RA Carver L. A., Hogenesch J. B., Bradfield C. A. RT Tissue specific expression of the rat Ah-receptor and ARNT mRNAs RL Nucleic Acids Res. 22:3038-3044 (1994). RN [3]; RE0004050. RX PUBMED: 8139547. RA McGuire J., Whitelaw M., Pongratz I., Gustafsson J. A., Poellinger L. RT A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor RL Mol. Cell. Biol. 14:2438-2446 (1994). RN [4]; RE0005820. RX PUBMED: 7628454. RA Lindebro M. C., Poellinger L., Whitelaw M. L. RT Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex RL EMBO J. 14:3528-3539 (1995). RN [5]; RE0063464. RX PUBMED: 16484282. RA Metz R. P., Kwak H. I., Gustafson T., Laffin B., Porter W. W. RT Differential transcriptional regulation by mouse single-minded 2s. RL J. Biol. Chem. 281:10839-10848 (2006). RN [6]; RE0066620. RX PUBMED: 17826745. RA Friedman E. R., Fan C. M. RT Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription. RL Biochem. Biophys. Res. Commun. 363:113-118 (2007). XX //