AC T00750
XX
ID T00750
XX
DT 20.10.1992 (created); ewi.
CO Copyright (C), QIAGEN.
XX
FA Sim
XX
SY Sim; Single-minded.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL C0010; bHLH.
XX
SZ 673 AA; 73.6 kDa (cDNA) (calc.).
XX
SQ MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGL
SQ GEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG
SQ NSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEI
SQ EKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHS
SQ LPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMA
SQ MRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSERE
SQ VKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQ
SQ AQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPP
SQ TNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTAS
SQ SAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANS
SQ NSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHL
SQ MEQQHLQYQYATW
XX
SC Swiss-Prot#P05709-2
XX
FT 1 54 
PS50888; HLH.
FT 2 54 
PF00010; Helix-loop-helix DNA-binding domain.
FT 6 59 
SM00353; finulus.
FT 25 321 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 76 148 
PS50112; PAS.
FT 78 144 
SM00091; pas_2.
FT 78 191 
PF00989; PAS fold.
FT 244 310 
SM00091; pas_2.
FT 257 312 
PS50112; PAS.
FT 316 359 
SM00086; pac_2.
XX
SF PAS domain of homology between per, arnt, and sim [3];
SF mediates dimerization of Sim with Per (periodic) which regulates the circadian rhythm [2];
SF in a heterodimeric complex with (human) Arnt, Sim recognizes the 5'-half-site sequence GTRC [4];
XX
FF master regulator of CNS midline development [1];
XX
IN T01346 arnt-isoform1; human, Homo sapiens.
IN T01797 arnt; mouse, Mus musculus.
XX
DR TRANSPATH: MO000025150.
DR EMBL: M19020;
DR UniProtKB: P05709-2;
DR FLYBASE: FBgn0004666; sim.
XX
RN [1]; RE0000203.
RX PUBMED: 1760843.
RA Nambu J. R., Lewis J. O., Wharton jr K. A., Crews St. T.
RT The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
RL Cell 67:1157-1167 (1991).
RN [2]; RE0003625.
RX PUBMED: 8391649.
RA Huang Z. J., Edery I., Rosbash M.
RT PAS is a dimerization domain common to Drosophila Period and several transcription factors
RL Nature 364:259-262 (1993).
RN [3]; RE0003626.
RX PUBMED: 3345560.
RA Crews S. T., Thomas J. B., Goodman C. S.
RT The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
RL Cell 52:143-151 (1988).
RN [4]; RE0003789.
RX PUBMED: 7592839.
RA Swanson H. I., Chan W. K., Bradfield C. A.
RT DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins
RL J. Biol. Chem. 270:26292-26302 (1995).
XX
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