AC T00018
AS T00194.
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ID T00018
XX
DT 25.01.1993 (created); hse.
DT 16.02.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA AhR
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SY Ah receptor; AhR; aryl hydrocarbon receptor; dioxin receptor; XRE-binding factor.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005185 Ahr.
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CL C0010; bHLH; 1.2.5.1.1.
XX
SF detectable as 6S and 9S form;
SF 95 kDa: ligand-binding subunit;
SF Stokes radius: 7.1 nm [4] [6];
SF dissociation into subunits upon prolonged treatment with 0.4 M KCl sedimenting with 4.9-5.6 S [4];
SF pI(calc.) = 5.98 [16];
SF pI(exp.) = 5.2-5.7 [17];
SF in heterodimeric complexes with Arnt, AhR preferably recognizes the half-site sequence TYGC [12];
SF interacts with hsp90 [5];
SF closely adjacent or overlapping domains for hsp90- and ligand-binding [13] [18];
SF other reports show interaction of hsp90 with the DNA-binding domain [15];
SF hsp90-interaction provides conformation suitable for ligand- and DNA-binding [13] [15] [18];
SF hsp90 represses, ligand-binding derepresses trans-activation domain [18];
SF possibly, another component associates with AhR to a 165-kDa complex [19];
SF transient activation of AhR depends on ligand-binding and a phosphorylation step [3] [11] [9] [14];
SF interaction with Arnt promotes release of ligand-bound AhR from hsp90 [20];
SF Ahr heterodimerizes with Arnt through its PAS domain (homology domain with Drosophila Per and Sim) [21];
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EX dorsal root ganglion,,,Theiler Stage 19; detectable; immunohistochemistry / immunocytochemistry; protein; [27].
EX heart,,,Theiler Stage 19; detectable; immunohistochemistry / immunocytochemistry; protein; [27].
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FF activator, binds to xenobiotic response element [11] [9] [2];
FF DNA-binding can be abolished by phosphatase treatment [3];
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IN T01346 arnt-isoform1; human, Homo sapiens.
IN T01797 arnt; mouse, Mus musculus.
IN T00992 Hsp90; human, Homo sapiens.
IN T09997 Hsp90; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T00595 RelA-p65; mouse, Mus musculus.
IN T04689 SMRT; human, Homo sapiens.
IN T00818 TFIIB; human, Homo sapiens.
XX
MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M00139 V$AHR_01.
MX M00778 V$AHR_Q5.
MX M01855 V$AHR_Q6.
MX M07347 V$AHR_Q6_01.
XX
BS R02656.
BS R04653.
BS R04655.
BS R13350.
BS R29931.
BS R13287.
BS R13240.
BS R38613.
BS R13150.
BS R02649.
BS R02650.
BS R02651.
BS R02652.
BS R02653.
BS R02654.
BS R24735.
BS R31478.
BS R34038.
BS R64064.
BS R64067.
BS R64070.
BS R73395.
BS R73396.
BS R73398.
BS R67422.
BS R13237.
BS R13238.
BS R62505.
BS R25837.
BS R25838.
BS R25839.
BS R71971.
BS R71972.
BS R37454.
BS R34389.
BS R34388.
BS R34387.
BS R34386.
BS R34346.
BS R00267.
BS R00268.
BS R00272.
BS R13284.
BS R13283.
XX
DR TRANSPATH: MO000024646.
DR UniProtKB: P30561;
XX
RN [1]; RE0000433.
RX PUBMED: 2153080.
RA Wilhelmsson A., Cuthill S., Denis M., Wikstroem A.-C., Gustafsson J. A., Poellinger L.
RT The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein
RL EMBO J. 9:69-76 (1990).
RN [2]; RE0000896.
RX PUBMED: 2550446.
RA Denison M. S., Fisher J. M., Whitlock J. P.
RT Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex
RL J. Biol. Chem. 264:16478-16482 (1989).
RN [3]; RE0001030.
RX PUBMED: 1653248.
RA Pongratz I., Stroemstedt P.-E., Mason G. G. F., Poellinger L.
RT Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment
RL J. Biol. Chem. 266:16813-16817 (1991).
RN [4]; RE0001099.
RX PUBMED: 3005314.
RA Denison M. S., Vella L. M., Okeys A. B.
RT Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin
RL J. Biol. Chem. 261:3987-3995 (1986).
RN [5]; RE0001108.
RX PUBMED: 2843537.
RA Perdew G. H.
RT Association of the Ah receptor with the 90-kDa heat shock protein
RL J. Biol. Chem. 263:13802-13806 (1988).
RN [6]; RE0001109.
RX PUBMED: 3029114.
RA Cuthill S., Poellinger L., Gustafsson J.-A.
RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7
RL J. Biol. Chem. 262:3477-3481 (1987).
RN [7]; RE0001231.
RX PUBMED: 2548080.
RA Neuhold L. A., Shirayoshi Y., Ozato K., Jones J. E., Nebert D. W.
RT Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis-Acting Elements during Induction
RL Mol. Cell. Biol. 9:2378-2386 (1989).
RN [8]; RE0001457.
RX PUBMED: 2325638.
RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B.
RT Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene
RL Mol. Cell. Biol. 10:1841-1852 (1990).
RN [9]; RE0002273.
RX PUBMED: 2833743.
RA Denison M. S., Fisher J. M., Whitlock jr J. P.
RT Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional activator
RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988).
RN [10]; RE0002274.
RX PUBMED: 2536161.
RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A.
RT Specific protein-DNA interactions at a xenobiotic-responsive element: Copurification of dioxin receptor and DNA-binding affinity
RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989).
RN [11]; RE0002275.
RX PUBMED: 3413062.
RA Fujisawa-Sehara A., Yamane M., Fuji-Kuriyama Y.
RT A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: Its possible translocation to nucleus
RL Proc. Natl. Acad. Sci. USA 85:5859-5863 (1988).
RN [12]; RE0003789.
RX PUBMED: 7592839.
RA Swanson H. I., Chan W. K., Bradfield C. A.
RT DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins
RL J. Biol. Chem. 270:26292-26302 (1995).
RN [13]; RE0004038.
RX PUBMED: 8223432.
RA Whitelaw M. L., Goettlicher M., Gustafsson J. A., Poelinger L.
RT Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor
RL EMBO J. 12:4169-4179 (1993).
RN [14]; RE0004040.
RX PUBMED: 8065302.
RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B.
RT Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor
RL Mol. Cell. Biol. 14:5653-5660 (1994).
RN [15]; RE0004041.
RX PUBMED: 7823943.
RA Antonsson C., Whitelaw M. L., McGuire J., Gustafsson J. -A., Poellinger L.
RT Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains
RL Mol. Cell. Biol. 15:756-765 (1995).
RN [16]; RE0004043.
RX PUBMED: 1325649.
RA Burbach K. M., Poland A., Bradfield C. A.
RT Cloning of the Ah-receptor cDNA reveals a distinctive-ligand-activated transcription factor
RL Proc. Natl. Acad. Sci. USA 89:8185-8189 (1992).
RN [17]; RE0004044.
RX PUBMED: 2169866.
RA Perdew G. H., Hollenback C. E.
RT Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogenity by two dimensional gel electrophoresis
RL Biochemistry 29:6210-6214 (1990).
RN [18]; RE0004048.
RX PUBMED: 7969169.
RA Whitelaw M. L., Gustafsson J. A., Poellinger L.
RT Identification of transactivation and repression functions of the dioxin receptor and its basic helix-lop-helix/PAS partner Arnt: inductive versus constitutive modes of regulation
RL Mol. Cell. Biol. 14:8343-8355 (1994).
RN [19]; RE0004049.
RX PUBMED: 8163517.
RA de Morais S. M. F., Giannone J. V., Okey A. B.
RT Photoaffinity labeling of Ah receptor with 3-[3H]methylcolanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein
RL J. Biol. Chem. 269:12129-12136 (1994).
RN [20]; RE0004050.
RX PUBMED: 8139547.
RA McGuire J., Whitelaw M., Pongratz I., Gustafsson J. A., Poellinger L.
RT A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor
RL Mol. Cell. Biol. 14:2438-2446 (1994).
RN [21]; RE0005820.
RX PUBMED: 7628454.
RA Lindebro M. C., Poellinger L., Whitelaw M. L.
RT Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex
RL EMBO J. 14:3528-3539 (1995).
RN [22]; RE0008590.
RX PUBMED: 8407937.
RA Matsushita N., Sogawa K., Ema M., Yoshida A., Fujii-Kuriyama Y.
RT A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt
RL J. Biol. Chem. 268:21002- 21006 (1993).
RN [23]; RE0022462.
RX PUBMED: 12409613.
RA Song J., Clagett-Dame M., Peterson R. E., Hahn M. E., Westler W. M., Sicinski R. R., DeLuca H. F.
RT A ligand for the aryl hydrocarbon receptor isolated from lung.
RL Proc. Natl. Acad. Sci. USA 99:14694-14699 (2002).
RN [24]; RE0022474.
RX PUBMED: 11259606.
RA Kazlauskas A., Sundstrom S., Poellinger L., Pongratz I.
RT The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor.
RL Mol. Cell. Biol. 21:2594-2607 (2001).
RN [25]; RE0022504.
RX PUBMED: 10731723.
RA Ikuta T., Tachibana T., Watanabe J., Yoshida M., Yoneda Y., Kawajiri K.
RT Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor.
RL J. Biochem. 127:503-509 (2000).
RN [26]; RE0067592.
RX PUBMED: 20478272.
RA Reyes-Hernandez O. D., Mejia-Garcia A., Sanchez-Ocampo E. M., Cabanas-Cortes M. A., Ramirez P., Chavez-Gonzalez L., Gonzalez F. J., Elizondo G.
RT Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: Implications for p53 ubiquitination.
RL Biochem. Pharmacol. 80:932-940 (2010).
RN [27]; RE0018159.
RX PUBMED: 12215427.
RA Antenos M., Casper R. F., Brown T. J.
RT Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.
RL J. Biol. Chem. 277:44028-44034 (2002).
RN [28]; RE0022536.
RX PUBMED: 10428779.
RA Kumar M. B., Tarpey R. W., Perdew G. H.
RT Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs.
RL J. Biol. Chem. 274:22155-22164 (1999).
RN [29]; RE0022496.
RX PUBMED: 12065584.
RA Berg P., Pongratz I.
RT Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor.
RL J. Biol. Chem. 277:32310-32319 (2002).
RN [30]; RE0022490.
RX PUBMED: 11805120.
RA Kazlauskas A., Poellinger L., Pongratz I.
RT Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90.
RL J. Biol. Chem. 277:11795-11801 (2002).
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