TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00018 AS T00194. XX ID T00018 XX DT 25.01.1993 (created); hse. DT 16.02.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA AhR XX SY Ah receptor; AhR; aryl hydrocarbon receptor; dioxin receptor; XRE-binding factor. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005185 Ahr. XX CL C0010; bHLH; XX SF detectable as 6S and 9S form; SF 95 kDa: ligand-binding subunit; SF Stokes radius: 7.1 nm [4] [6]; SF dissociation into subunits upon prolonged treatment with 0.4 M KCl sedimenting with 4.9-5.6 S [4]; SF pI(calc.) = 5.98 [16]; SF pI(exp.) = 5.2-5.7 [17]; SF in heterodimeric complexes with Arnt, AhR preferably recognizes the half-site sequence TYGC [12]; SF interacts with hsp90 [5]; SF closely adjacent or overlapping domains for hsp90- and ligand-binding [13] [18]; SF other reports show interaction of hsp90 with the DNA-binding domain [15]; SF hsp90-interaction provides conformation suitable for ligand- and DNA-binding [13] [15] [18]; SF hsp90 represses, ligand-binding derepresses trans-activation domain [18]; SF possibly, another component associates with AhR to a 165-kDa complex [19]; SF transient activation of AhR depends on ligand-binding and a phosphorylation step [3] [11] [9] [14]; SF interaction with Arnt promotes release of ligand-bound AhR from hsp90 [20]; SF Ahr heterodimerizes with Arnt through its PAS domain (homology domain with Drosophila Per and Sim) [21]; XX EX dorsal root ganglion,,,Theiler Stage 19; detectable; immunohistochemistry / immunocytochemistry; protein; [27]. EX heart,,,Theiler Stage 19; detectable; immunohistochemistry / immunocytochemistry; protein; [27]. XX FF activator, binds to xenobiotic response element [11] [9] [2]; FF DNA-binding can be abolished by phosphatase treatment [3]; XX IN T01346 arnt-isoform1; human, Homo sapiens. IN T01797 arnt; mouse, Mus musculus. IN T00992 Hsp90; human, Homo sapiens. IN T09997 Hsp90; mouse, Mus musculus. IN T10542 p300; mouse, Mus musculus. IN T00595 RelA-p65; mouse, Mus musculus. IN T04689 SMRT; human, Homo sapiens. IN T00818 TFIIB; human, Homo sapiens. XX MX M00235 V$AHRARNT_01. MX M00237 V$AHRARNT_02. MX M00976 V$AHRHIF_Q6. MX M00139 V$AHR_01. MX M00778 V$AHR_Q5. MX M01855 V$AHR_Q6. MX M07347 V$AHR_Q6_01. XX BS R02656. BS R04653. BS R04655. BS R13350. BS R29931. BS R13287. BS R13240. BS R38613. BS R13150. BS R02649. BS R02650. BS R02651. BS R02652. BS R02653. BS R02654. BS R24735. BS R31478. BS R34038. BS R64064. BS R64067. BS R64070. BS R73395. BS R73396. BS R73398. BS R67422. BS R13237. BS R13238. BS R62505. BS R25837. BS R25838. BS R25839. BS R71971. BS R71972. BS R37454. BS R34389. BS R34388. BS R34387. BS R34386. BS R34346. BS R00267. BS R00268. BS R00272. BS R13284. BS R13283. XX DR TRANSPATH: MO000024646. DR UniProtKB: P30561; XX RN [1]; RE0000433. RX PUBMED: 2153080. RA Wilhelmsson A., Cuthill S., Denis M., Wikstroem A.-C., Gustafsson J. A., Poellinger L. RT The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein RL EMBO J. 9:69-76 (1990). RN [2]; RE0000896. RX PUBMED: 2550446. RA Denison M. S., Fisher J. M., Whitlock J. P. RT Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex RL J. Biol. Chem. 264:16478-16482 (1989). RN [3]; RE0001030. RX PUBMED: 1653248. RA Pongratz I., Stroemstedt P.-E., Mason G. G. F., Poellinger L. RT Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment RL J. Biol. Chem. 266:16813-16817 (1991). RN [4]; RE0001099. RX PUBMED: 3005314. RA Denison M. S., Vella L. M., Okeys A. B. RT Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin RL J. Biol. Chem. 261:3987-3995 (1986). RN [5]; RE0001108. RX PUBMED: 2843537. RA Perdew G. H. RT Association of the Ah receptor with the 90-kDa heat shock protein RL J. Biol. Chem. 263:13802-13806 (1988). RN [6]; RE0001109. RX PUBMED: 3029114. RA Cuthill S., Poellinger L., Gustafsson J.-A. RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7 RL J. Biol. Chem. 262:3477-3481 (1987). RN [7]; RE0001231. RX PUBMED: 2548080. RA Neuhold L. A., Shirayoshi Y., Ozato K., Jones J. E., Nebert D. W. RT Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis-Acting Elements during Induction RL Mol. Cell. Biol. 9:2378-2386 (1989). RN [8]; RE0001457. RX PUBMED: 2325638. RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B. RT Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene RL Mol. Cell. Biol. 10:1841-1852 (1990). RN [9]; RE0002273. RX PUBMED: 2833743. RA Denison M. S., Fisher J. M., Whitlock jr J. P. RT Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional activator RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988). RN [10]; RE0002274. RX PUBMED: 2536161. RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A. RT Specific protein-DNA interactions at a xenobiotic-responsive element: Copurification of dioxin receptor and DNA-binding affinity RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989). RN [11]; RE0002275. RX PUBMED: 3413062. RA Fujisawa-Sehara A., Yamane M., Fuji-Kuriyama Y. RT A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: Its possible translocation to nucleus RL Proc. Natl. Acad. Sci. USA 85:5859-5863 (1988). RN [12]; RE0003789. RX PUBMED: 7592839. RA Swanson H. I., Chan W. K., Bradfield C. A. RT DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins RL J. Biol. Chem. 270:26292-26302 (1995). RN [13]; RE0004038. RX PUBMED: 8223432. RA Whitelaw M. L., Goettlicher M., Gustafsson J. A., Poelinger L. RT Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor RL EMBO J. 12:4169-4179 (1993). RN [14]; RE0004040. RX PUBMED: 8065302. RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B. RT Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor RL Mol. Cell. Biol. 14:5653-5660 (1994). RN [15]; RE0004041. RX PUBMED: 7823943. RA Antonsson C., Whitelaw M. L., McGuire J., Gustafsson J. -A., Poellinger L. RT Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains RL Mol. Cell. Biol. 15:756-765 (1995). RN [16]; RE0004043. RX PUBMED: 1325649. RA Burbach K. M., Poland A., Bradfield C. A. RT Cloning of the Ah-receptor cDNA reveals a distinctive-ligand-activated transcription factor RL Proc. Natl. Acad. Sci. USA 89:8185-8189 (1992). RN [17]; RE0004044. RX PUBMED: 2169866. RA Perdew G. H., Hollenback C. E. RT Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogenity by two dimensional gel electrophoresis RL Biochemistry 29:6210-6214 (1990). RN [18]; RE0004048. RX PUBMED: 7969169. RA Whitelaw M. L., Gustafsson J. A., Poellinger L. RT Identification of transactivation and repression functions of the dioxin receptor and its basic helix-lop-helix/PAS partner Arnt: inductive versus constitutive modes of regulation RL Mol. Cell. Biol. 14:8343-8355 (1994). RN [19]; RE0004049. RX PUBMED: 8163517. RA de Morais S. M. F., Giannone J. V., Okey A. B. RT Photoaffinity labeling of Ah receptor with 3-[3H]methylcolanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein RL J. Biol. Chem. 269:12129-12136 (1994). RN [20]; RE0004050. RX PUBMED: 8139547. RA McGuire J., Whitelaw M., Pongratz I., Gustafsson J. A., Poellinger L. RT A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor RL Mol. Cell. Biol. 14:2438-2446 (1994). RN [21]; RE0005820. RX PUBMED: 7628454. RA Lindebro M. C., Poellinger L., Whitelaw M. L. RT Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex RL EMBO J. 14:3528-3539 (1995). RN [22]; RE0008590. RX PUBMED: 8407937. RA Matsushita N., Sogawa K., Ema M., Yoshida A., Fujii-Kuriyama Y. RT A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt RL J. Biol. Chem. 268:21002- 21006 (1993). RN [23]; RE0022462. RX PUBMED: 12409613. RA Song J., Clagett-Dame M., Peterson R. E., Hahn M. E., Westler W. M., Sicinski R. R., DeLuca H. F. RT A ligand for the aryl hydrocarbon receptor isolated from lung. RL Proc. Natl. Acad. Sci. USA 99:14694-14699 (2002). RN [24]; RE0022474. RX PUBMED: 11259606. RA Kazlauskas A., Sundstrom S., Poellinger L., Pongratz I. RT The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. RL Mol. Cell. Biol. 21:2594-2607 (2001). RN [25]; RE0022504. RX PUBMED: 10731723. RA Ikuta T., Tachibana T., Watanabe J., Yoshida M., Yoneda Y., Kawajiri K. RT Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor. RL J. Biochem. 127:503-509 (2000). RN [26]; RE0067592. RX PUBMED: 20478272. RA Reyes-Hernandez O. D., Mejia-Garcia A., Sanchez-Ocampo E. M., Cabanas-Cortes M. A., Ramirez P., Chavez-Gonzalez L., Gonzalez F. J., Elizondo G. RT Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: Implications for p53 ubiquitination. RL Biochem. Pharmacol. 80:932-940 (2010). RN [27]; RE0018159. RX PUBMED: 12215427. RA Antenos M., Casper R. F., Brown T. J. RT Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. RL J. Biol. Chem. 277:44028-44034 (2002). RN [28]; RE0022536. RX PUBMED: 10428779. RA Kumar M. B., Tarpey R. W., Perdew G. H. RT Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. RL J. Biol. Chem. 274:22155-22164 (1999). RN [29]; RE0022496. RX PUBMED: 12065584. RA Berg P., Pongratz I. RT Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor. RL J. Biol. Chem. 277:32310-32319 (2002). RN [30]; RE0022490. RX PUBMED: 11805120. RA Kazlauskas A., Poellinger L., Pongratz I. RT Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90. RL J. Biol. Chem. 277:11795-11801 (2002). XX //