TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00595 XX ID T00595 XX DT 22.01.2008 (created); pch. DT 19.02.2016 (updated); mom. CO Copyright (C), QIAGEN. XX FA RelA-p65 XX SY NF-kappaB (p65); Rel-A; RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009183 Rela. XX CL C0020; Rel; XX SF the Rel domain constitutes the DNA-contacting domain either in homo- or in heterodimers; SF the affinity of the homodimer to kappaB sites is 4-fold to 13-fold lower than that of p50/p65 heterodimers T00588 [6]; SF cytoplasmic inhibitors (IkappaB-alpha and -beta) bind to the Rel domain of RelA-p65 [8] [1]; SF dimerization is important for inhibitor binding [3]; SF the Rel homology domain associates with C/EBPbeta bZIP [10]; XX CP ubiquitous; Mouse fibroblasts [20]. XX FF RelA-p65 shows nuclear translocation in response to the iron loading in leukocytes present in DLN (Draining Lymph Node)) [23]; FF the heterodimer with p50 avidly binds to asymmetric DNA-sequences; FF at some sequences, its homodimers may act as transcriptional activators [1]; FF target for the cytoplasmic inhibitor IkappaB [2] [4]; FF RelA-p65 establishes an autoregulatory loop by activating the IkappaB-alpha gene [3]; FF disruption of the RelA-p65 gene causes massive liver degeneration and embryonic lethality [7]; FF RelA-p65 /p65 is found constitutively associated with c-fos promoter although EMSA studies revealed no NF-kappaB DNA binding to this site of c-fos promoter in vitro [12]; XX IN T00018 AhR; mouse, Mus musculus. IN T00168 c-Rel; human, Homo sapiens. IN T01318 CBP; mouse, Mus musculus. IN T05868 Clock; mouse, Mus musculus. IN T18364 Clock; Mammalia. IN T19612 DRIP205; mouse, Mus musculus. IN T22155 GILZ; mouse, Mus musculus. IN T23418 HDAC1; mouse, Mus musculus. IN T27825 Hes6; mouse, Mus musculus. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T00414 IkappaB-beta; human, Homo sapiens. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T22436 IkappaB-epsilon-xxb2; human, Homo sapiens. IN T01936 IKappaB; mouse, Mus musculus. IN T17574 NF-kappaB1-p50; mouse, Mus musculus. IN T19130 NF-kappaB2-p52; mouse, Mus musculus. IN T19129 NF-kappaB2; mouse, Mus musculus. IN T01427 p300; human, Homo sapiens. IN T10542 p300; mouse, Mus musculus. IN T01923 p50; mouse, Mus musculus. IN T27517 RelB; Mammalia. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00052 V$NFKAPPAB65_01. MX M00054 V$NFKAPPAB_01. MX M00774 V$NFKB_Q6_01. MX M03563 V$RELA_Q6. XX BS R20924. BS R20630. BS R30130. BS R74080. BS R19559. BS R19561. BS R02683. BS R66038. BS R66040. BS R66041. BS R00920. BS R00923. BS R14486. BS R56466. BS R11382. BS R40298. BS R63242. BS R14565. BS R58310. BS R58312. BS R66911. BS R26434. BS R24848. BS R69118. BS R69119. BS R69120. BS R69121. BS R69122. BS R69123. BS R16304. BS R62419. BS R62422. BS R36629. BS R62926. BS R60389. BS R36209. BS R00879. BS R14483. BS R26192. BS R72708. BS R65965. BS R28386. BS R25624. BS R24177. BS R69124. BS R72707. BS R56278. BS R63095. BS R63099. BS R72700. BS R26647. BS R59488. BS R01058. BS R42321. BS R42322. BS R72436. BS R70346. BS R70347. BS R72438. BS R33143. BS R33145. BS R68464. BS R68467. BS R37830. BS R37831. BS R40270. BS R08126. BS R61673. BS R29587. BS R73505. BS R38713. BS R73358. BS R29344. BS R64907. BS R64908. BS R28248. BS R33510. BS R33513. BS R62434. BS R62436. BS R22667. BS R22670. BS R61241. BS R14690. BS R14691. BS R72706. BS R57839. BS R57845. BS R41875. BS R63059. BS R26532. BS R04703. BS R67925. BS R29144. BS R30716. XX DR TRANSPATH: MO000019364. DR TRANSCOMPEL: C00154. DR TRANSCOMPEL: C00333. DR TRANSCOMPEL: C00336. DR TRANSCOMPEL: C00339. DR TRANSCOMPEL: C00352. DR TRANSCOMPEL: C00460. DR UniProtKB: Q04207; TF65_MOUSE. XX RN [1]; RE0000176. RX PUBMED: 2001591. RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [2]; RE0000285. RX PUBMED: 3076097. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988). RN [3]; RE0001374. RX PUBMED: 2796988. RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [4]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [5]; RE0003823. RX PUBMED: 7797554. RA Schmitz M. L., dos Santos Silva M. A., Baeuerle P. A. RT Transactivation domain 2 (TA2) of p65 NF-kappaB RL J. Biol. Chem. 270:15576-15584 (1995). RN [6]; RE0004518. RX PUBMED: 1577272. RA Fujita T., Nolan G. P., Ghosh S., Baltimore D. RT Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappaB RL Genes Dev. 6:775-787 (1992). RN [7]; RE0004547. RX PUBMED: 7603567. RA Beg A. A., Sha W. C., Bronson R. T., Ghosh S., Baltimore D. RT Embryonic lethality and liver degeneration in mice lacking the ReIA component of NF-kappaB RL Nature 376:167-170 (1995). RN [8]; RE0004550. RX PUBMED: 7867065. RA Thompson J. E., Phillips R. J., Erdjument-Bromage H., Tempst P., Ghosh S. RT IkappaB-beta regulates the persistent response in a biphasic activation of NF-kappaB RL Cell 80:573-582 (1995). RN [9]; RE0004553. RX PUBMED: 1299224. RA Kitajima I., Shinohara T., Bilakovics J., Brown D. A., Xu X., Nerenberg M. RT Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappaB RL Science 258:1792-1795 (1992). RN [10]; RE0006254. RX PUBMED: 8234276. RA Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T., Akira S. RT Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8 RL Proc. Natl. Acad. Sci. USA 90:10193-10197 (1993). RN [11]; RE0013471. RX PUBMED: 9135156. RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A. RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. RL EMBO J. 16:1413-1426 (1997). RN [12]; RE0025411. RX PUBMED: 15155743. RA Anest V., Cogswell P. C., Baldwin AS J. r. RT IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation. RL J. Biol. Chem. 279:31183-31189 (2004). RN [13]; RE0030415. RX PUBMED: 12842894. RA Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T., Saiki I. RT Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. RL J. Biol. Chem. 278:36916-23 (2003). RN [14]; RE0030779. RX PUBMED: 12556537. RA Muller J. R., Siebenlist U. RT Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. RL J. Biol. Chem. 278:12006-12 (2003). RN [15]; RE0042226. RX PUBMED: 12960163. RA Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O. RT Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1 RL J. Biol. Chem. 278:45145-53 (2003). RN [16]; RE0048413. RX PUBMED: 16728495. RA Zeold A., Doleschall M., Haffner M. C., Capelo L. P., Menyhert J., Liposits Z., da Silva W. S., Bianco A. C., Kacskovics I., Fekete C., Gereben B. RT Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. RL Endocrinology 147:4419-4429 (2006). RN [17]; RE0049976. RX PUBMED: 17434128. RA Huang W. C., Ju T. K., Hung M. C., Chen C. C. RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. RL Mol. Cell 26:75-87 (2007). RN [18]; RE0050028. RX PUBMED: 14690596. RA Ryo A., Suizu F., Yoshida Y., Perrem K., Liou Y. C., Wulf G., Rottapel R., Yamaoka S., Lu K. P. RT Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. RL Mol. Cell 12:1413-1426 (2003). RN [19]; RE0051581. RX PUBMED: 17932028. RA Doyle S. L., Jefferies C. A., Feighery C., O'Neill L. A. RT Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase. RL J. Biol. Chem. 282:36953-36960 (2007). RN [20]; RE0051710. RX PUBMED: 15988009. RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C. RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. RL Mol. Cell. Biol. 25:5933-5946 (2005). RN [21]; RE0051888. RX PUBMED: 17268551. RA Orlova V. V., Choi E. Y., Xie C., Chavakis E., Bierhaus A., Ihanus E., Ballantyne C. M., Gahmberg C. G., Bianchi M. E., Nawroth P. P., Chavakis T. RT A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. RL EMBO J. 26:1129-1139 (2007). RN [22]; RE0052059. RX PUBMED: 11931769. RA Zhong H., May M. J., Jimi E., Ghosh S. RT The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. RL Mol. Cell 9:625-636 (2002). RN [23]; RE0053260. RX PUBMED: 16702015. RA Bisti S., Soteriadou K. RT Is the reactive oxygen species-dependent-NF-kappaB activation observed in iron-loaded BALB/c mice a key process preventing growth of Leishmania major progeny and tissue-damage? RL Microbes Infect. 8:1473-1482 (2006). RN [24]; RE0053386. RX PUBMED: 18383035. RA Gregory D. J., Godbout M., Contreras I., Forget G., Olivier M. RT A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression. RL Eur. J. Immunol. 38:1071-1081 (2008). RN [25]; RE0053439. RX PUBMED: 17468759. RA Tanaka T., Grusby M. J., Kaisho T. RT PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. RL Nat. Immunol. 8:584-591 (2007). RN [26]; RE0053491. RX PUBMED: 16415872. RA Mansell A., Smith R., Doyle S. L., Gray P., Fenner J. E., Crack P. J., Nicholson S. E., Hilton D. J., O'Neill L. A., Hertzog P. J. RT Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. RL Nat. Immunol. 7:148-155 (2006). RN [27]; RE0053534. RX PUBMED: 15755876. RA Hu J., Colburn N. H. RT Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. RL Mol. Cancer Res. 3:100-109 (2005). RN [28]; RE0053762. RX PUBMED: 12874295. RA Maier H. J., Marienfeld R., Wirth T., Baumann B. RT Critical role of RelB serine 368 for dimerization and p100 stabilization. RL J. Biol. Chem. 278:39242-39250 (2003). RN [29]; RE0054033. RX PUBMED: 12789343. RA Anest V., Hanson J. L., Cogswell P. C., Steinbrecher K. A., Strahl B. D., Baldwin A. S. RT A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. RL Nature 423:659-663 (2003). RN [30]; RE0054100. RX PUBMED: 15858576. RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M. RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. RL Nature 434:1138-1143 (2005). RN [31]; RE0054106. RX PUBMED: 9314550. RA Ishikawa H., Carrasco D., Claudio E., Ryseck R. P., Bravo R. RT Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. RL J. Exp. Med. 186:999-1014 (1997). RN [32]; RE0054833. RX PUBMED: 17690092. RA Lou H., Kaplowitz N. RT Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. RL J. Biol. Chem. 282:29470-29481 (2007). RN [33]; RE0055243. RX PUBMED: 17485511. RA Kawagoe T., Sato S., Jung A., Yamamoto M., Matsui K., Kato H., Uematsu S., Takeuchi O., Akira S. RT Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. RL J. Exp. Med. 204:1013-1024 (2007). RN [34]; RE0055294. RX PUBMED: 18719121. RA Chen N. J., Chio I. I., Lin W. J., Duncan G., Chau H., Katz D., Huang H. L., Pike K. A., Hao Z., Su Y. W., Yamamoto K., de Pooter R. F., Zuniga-Pflucker J. C., Wakeham A., Yeh W. C., Mak T. W. RT Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. RL Proc. Natl. Acad. Sci. USA 105:12429-12434 (2008). RN [35]; RE0055365. RX PUBMED: 16924232. RA Takada Y., Ichikawa H., Pataer A., Swisher S., Aggarwal B. B. RT Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. RL Oncogene 26:1201-1212 (2007). RN [36]; RE0055632. RX PUBMED: 19201871. RA Bode K. A., Schmitz F., Vargas L., Heeg K., Dalpke A. H. RT Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction. RL J. Immunol. 182:2176-2184 (2009). RN [37]; RE0062705. RX PUBMED: 17916553. RA Nguyen M. T., Favelyukis S., Nguyen A. K., Reichart D., Scott P. A., Jenn A., Liu-Bryan R., Glass C. K., Neels J. G., Olefsky J. M. RT A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. RL J. Biol. Chem. 282:35279-35292 (2007). RN [38]; RE0063141. RX PUBMED: 16222708. RA Ulivi V., Tutolo G., Mallein-Gerin F., Daga A., Cancedda R., Cancedda F. D. RT A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes. RL J. Cell. Physiol. 206:728-737 (2006). RN [39]; RE0064883. RX PUBMED: 18482989. RA Zhong M. C., Veillette A. RT Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity. RL J. Biol. Chem. 283:19255-19264 (2008). RN [40]; RE0065182. RX PUBMED: 19377466. RA Chew J., Biswas S., Shreeram S., Humaidi M., Wong E. T., Dhillion M. K., Teo H., Hazra A., Fang C. C., Lopez-Collazo E., Bulavin D. V., Tergaonkar V. RT WIP1 phosphatase is a negative regulator of NF-kappaB signalling. RL Nat. Cell Biol. 11:659-666 (2009). RN [41]; RE0065221. RX PUBMED: 18523265. RA Cross J. L., Kott K., Miletic T., Johnson P. RT CD45 regulates TLR-induced proinflammatory cytokine and IFN-beta secretion in dendritic cells. RL J. Immunol. 180:8020-8029 (2008). RN [42]; RE0065287. RX PUBMED: 19820695. RA Lamb A., Yang X. D., Tsang Y. H., Li J. D., Higashi H., Hatakeyama M., Peek R. M., Blanke S. R., Chen L. F. RT Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. RL EMBO Rep. 10:1242-1249 (2009). RN [43]; RE0065404. RX PUBMED: 19592497. RA Verstak B., Nagpal K., Bottomley S. P., Golenbock D. T., Hertzog P. J., Mansell A. RT MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. RL J. Biol. Chem. 284:24192-24203 (2009). RN [44]; RE0065527. RX PUBMED: 19531803. RA Wall E. A., Zavzavadjian J. R., Chang M. S., Randhawa B., Zhu X., Hsueh R. C., Liu J., Driver A., Bao X. R., Sternweis P. C., Simon M. I., Fraser I. D. RT Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. RL Sci. Signal. 2:ra28 (2009). RN [45]; RE0066777. RX PUBMED: 20026373. RA Cichocki M., Blumczynska J., Baer-Dubowska W. RT Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis. RL Toxicology 268:118-124 (2010). RN [46]; RE0068433. RX PUBMED: 20946687. RA Kaushik D. K., Gupta M., Das S., Basu A. RT Kruppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation. RL J. Neuroinflammation 7:68 (2010). RN [47]; RE0068743. RX PUBMED: 12825186. RA Jouault T., Ibata-Ombetta S., Takeuchi O., Trinel P. A., Sacchetti P., Lefebvre P., Akira S., Poulain D. RT Candida albicans phospholipomannan is sensed through toll-like receptors. RL J. Infect. Dis. 188:165-172 (2003). RN [48]; RE0068850. RX PUBMED: 20200270. RA Hoshino K., Sasaki I., Sugiyama T., Yano T., Yamazaki C., Yasui T., Kikutani H., Kaisho T. RT Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. RL J. Immunol. 184:3341-3345 (2010). RN [49]; RE0069238. RX PUBMED: 20811154. RA Demaria O., Pagni P. P., Traub S., de Gassart A., Branzk N., Murphy A. J., Valenzuela D. M., Yancopoulos G. D., Flavell R. A., Alexopoulou L. RT TLR8 deficiency leads to autoimmunity in mice. RL J. Clin. Invest. 120:3651-3662 (2010). RN [50]; RE0070198. RX PUBMED: 19890065. RA Qin Y. H., Dai S. M., Tang G. S., Zhang J., Ren D., Wang Z. W., Shen Q. RT HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products. RL J. Immunol. 183:6244-6250 (2009). RN [51]; RE0071600. RX PUBMED: 18436238. RA Trinh D. V., Zhu N., Farhang G., Kim B. J., Huxford T. RT The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. RL J. Mol. Biol. 379:122-135 (2008). RN [52]; RE0072570. RX PUBMED: 21455173. RA Gerlach B., Cordier S. M., Schmukle A. C., Emmerich C. H., Rieser E., Haas T. L., Webb A. I., Rickard J. A., Anderton H., Wong W. W., Nachbur U., Gangoda L., Warnken U., Purcell A. W., Silke J., Walczak H. RT Linear ubiquitination prevents inflammation and regulates immune signalling. RL Nature 471:591-596 (2011). RN [53]; RE0072608. RX PUBMED: 21455181. RA Ikeda F., Deribe Y. L., Skanland S. S., Stieglitz B., Grabbe C., Franz-Wachtel M., van Wijk S. J., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J. P., Schaefer L., Rittinger K., Macek B., Dikic I. RT SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. RL Nature 471:637-641 (2011). XX //