AC T00595
XX
ID T00595
XX
DT 22.01.2008 (created); pch.
DT 19.02.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA RelA-p65
XX
SY NF-kappaB (p65); Rel-A; RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009183 Rela.
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CL C0020; Rel; 6.1.1.2.1.
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SF the Rel domain constitutes the DNA-contacting domain either in homo- or in heterodimers;
SF the affinity of the homodimer to kappaB sites is 4-fold to 13-fold lower than that of p50/p65 heterodimers T00588 [6];
SF cytoplasmic inhibitors (IkappaB-alpha and -beta) bind to the Rel domain of RelA-p65 [8] [1];
SF dimerization is important for inhibitor binding [3];
SF the Rel homology domain associates with C/EBPbeta bZIP [10];
XX
CP ubiquitous; Mouse fibroblasts [20].
XX
FF RelA-p65 shows nuclear translocation in response to the iron loading in leukocytes present in DLN (Draining Lymph Node)) [23];
FF the heterodimer with p50 avidly binds to asymmetric DNA-sequences;
FF at some sequences, its homodimers may act as transcriptional activators [1];
FF target for the cytoplasmic inhibitor IkappaB [2] [4];
FF RelA-p65 establishes an autoregulatory loop by activating the IkappaB-alpha gene [3];
FF disruption of the RelA-p65 gene causes massive liver degeneration and embryonic lethality [7];
FF RelA-p65 /p65 is found constitutively associated with c-fos promoter although EMSA studies revealed no NF-kappaB DNA binding to this site of c-fos promoter in vitro [12];
XX
IN T00018 AhR; mouse, Mus musculus.
IN T00168 c-Rel; human, Homo sapiens.
IN T01318 CBP; mouse, Mus musculus.
IN T05868 Clock; mouse, Mus musculus.
IN T18364 Clock; Mammalia.
IN T19612 DRIP205; mouse, Mus musculus.
IN T22155 GILZ; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T27825 Hes6; mouse, Mus musculus.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T22436 IkappaB-epsilon-xxb2; human, Homo sapiens.
IN T01936 IKappaB; mouse, Mus musculus.
IN T17574 NF-kappaB1-p50; mouse, Mus musculus.
IN T19130 NF-kappaB2-p52; mouse, Mus musculus.
IN T19129 NF-kappaB2; mouse, Mus musculus.
IN T01427 p300; human, Homo sapiens.
IN T10542 p300; mouse, Mus musculus.
IN T01923 p50; mouse, Mus musculus.
IN T27517 RelB; Mammalia.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00052 V$NFKAPPAB65_01.
MX M00054 V$NFKAPPAB_01.
MX M00774 V$NFKB_Q6_01.
MX M03563 V$RELA_Q6.
XX
BS R20924.
BS R20630.
BS R30130.
BS R74080.
BS R19559.
BS R19561.
BS R02683.
BS R66038.
BS R66040.
BS R66041.
BS R00920.
BS R00923.
BS R14486.
BS R56466.
BS R11382.
BS R40298.
BS R63242.
BS R14565.
BS R58310.
BS R58312.
BS R66911.
BS R26434.
BS R24848.
BS R69118.
BS R69119.
BS R69120.
BS R69121.
BS R69122.
BS R69123.
BS R16304.
BS R62419.
BS R62422.
BS R36629.
BS R62926.
BS R60389.
BS R36209.
BS R00879.
BS R14483.
BS R26192.
BS R72708.
BS R65965.
BS R28386.
BS R25624.
BS R24177.
BS R69124.
BS R72707.
BS R56278.
BS R63095.
BS R63099.
BS R72700.
BS R26647.
BS R59488.
BS R01058.
BS R42321.
BS R42322.
BS R72436.
BS R70346.
BS R70347.
BS R72438.
BS R33143.
BS R33145.
BS R68464.
BS R68467.
BS R37830.
BS R37831.
BS R40270.
BS R08126.
BS R61673.
BS R29587.
BS R73505.
BS R38713.
BS R73358.
BS R29344.
BS R64907.
BS R64908.
BS R28248.
BS R33510.
BS R33513.
BS R62434.
BS R62436.
BS R22667.
BS R22670.
BS R61241.
BS R14690.
BS R14691.
BS R72706.
BS R57839.
BS R57845.
BS R41875.
BS R63059.
BS R26532.
BS R04703.
BS R67925.
BS R29144.
BS R30716.
XX
DR TRANSPATH: MO000019364.
DR TRANSCOMPEL: C00154.
DR TRANSCOMPEL: C00333.
DR TRANSCOMPEL: C00336.
DR TRANSCOMPEL: C00339.
DR TRANSCOMPEL: C00352.
DR TRANSCOMPEL: C00460.
DR UniProtKB: Q04207; TF65_MOUSE.
XX
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