AC T02719
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ID T02719
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DT 04.05.1999 (created); ewi.
DT 29.04.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HIF2A
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SY endothelial PAS-1; HIF-2alpha; HIF1alpha-like factor; HLF; hypoxia Induced Factor 2 alpha; hypoxia inducible transcription factor 2alpha; member of PAS superfamily 2; MOP2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006026 Epas1.
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CL C0010; bHLH; 1.2.5.1.7.
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SF heterodimerization partner, Arnt/HIF-1beta, is necessary for DNA binding [2];
SF part of the molecule carboxyl-terminal to the PAS domains is responsible for transactivation and for direct in vitro interactions with c-Ets-1 [5];
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CP (11d embryo:) endothelial cells of intersegmental blood vessels; (13d embryo:) endothelial cells of choroid plexus; (adult:) endothelial cells, decidual placenta cells, parenchymal lung cells, mesangial cells of renal cortex [1]; postnatal brain capillaries [5] [1] [5].
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FF activator [2] [5];
FF probably a specific regulator of genes in vascular endothelial cells [1] [2];
FF acts synergistically with c-Ets-1 to activate endothelial-specific Flk-1/KDR gene [5];
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IN T01797 arnt; mouse, Mus musculus.
IN T00115 c-Ets-1 68; chick, Gallus gallus.
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MX M01249 V$HIF2A_01.
MX M07356 V$HIF2A_Q6.
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BS R24274.
BS R65424.
BS R65430.
BS R31165.
BS R64686.
BS R64695.
BS R14473.
BS R14474.
BS R37904.
BS R67429.
BS R67431.
BS R67433.
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DR TRANSPATH: MO000026695.
DR TRANSCOMPEL: C00408.
DR TRANSCOMPEL: C00409.
DR UniProtKB: P97481;
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RN [1]; RE0013520.
RX PUBMED: 9000051.
RA Tian H., McKnight S. L., Russel D. W.
RT Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
RL Genes Dev. 11:72-82 (1997).
RN [2]; RE0013593.
RX PUBMED: 9113979.
RA Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y.
RT A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 alpha regulates the VEGF expression and is potentially involved in lung and vascular development
RL Proc. Natl. Acad. Sci. USA 94:4273-4278 (1997).
RN [3]; RE0013594.
RX PUBMED: 9178256.
RA Flamme I., Frohlich T., von Reutern M., Kappel A., Damert A., Risau W.
RT HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels
RL Mech. Dev. 63:51-60 (1997).
RN [4]; RE0022318.
RX PUBMED: 11823643.
RA Lando D., Peet D. J., Whelan D. A., Gorman J. J., Whitelaw M. L.
RT Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
RL Science 295:858-861 (2002).
RN [5]; RE0023729.
RX PUBMED: 12464608.
RA Elvert G., Kappel A., Heidenreich R., Englmeier U., Lanz S., Acker T., Rauter M., Plate K., Sieweke M., Breier G., Flamme I.
RT Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
RL J. Biol. Chem. 278:7520-7530 (2003).
RN [6]; RE0063072.
RX PUBMED: 15545625.
RA Brugarolas J., Lei K., Hurley R. L., Manning B. D., Reiling J. H., Hafen E., Witters L. A., Ellisen L. W., Kaelin WG J. r.
RT Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
RL Genes Dev. 18:2893-2904 (2004).
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