AC T00115
XX
ID T00115
XX
DT 26.10.1992 (created); ewi.
DT 13.07.2012 (updated); sup.
CO Copyright (C), QIAGEN.
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FA c-Ets-1 68
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SY c-Ets-1 68; p68c-Ets-1.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G045516 ETS1.
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CL C0016; ETS.
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SZ 485 AA; 55.0 kDa (cDNA) (calc.), 68 kDa (SDS)
XX
SQ MMSYYMDTTIGSTGPYPLARPGVMQGASSCCEDPWMPCRLQSACCPPRSCCPPWDEAAIQ
SQ EVPTGLEHYSTDMECADVPLLTPSSKEMMSQALKATFSGFAKEQQRLGIPKDPQQWTETH
SQ VRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKECFLELAPDFVGDILWEHLEILQKEE
SQ AKPYPANGVNAAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEEL
SQ LSLKYENDYPSVILRDPVQTDSLQTDYFTIKQEVVTPDNMCMGRASRGKLGGQDSFESIE
SQ SYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADMNK
SQ DKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWG
SQ KRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVK
SQ PDADE
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SC Swiss-Prot#P15062
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FT 97 180 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 97 180 
SM00251; SAM2_3.
FT 378 461 
PF00178; Ets-domain.
FT 378 463 
SM00413; etsneu2.
FT 379 459 
PS50061; ETS_DOMAIN_3.
FT 381 449 
PS50140; HSF_ETS.
XX
SF alternative splice variant: c-Ets-1 54, differing in the N-termini;
SF in addition to the mid-regional repressing domain, the C-terminal part of the molecule also inhibits DNA-binding [4];
SF phosphorylation (Ca-dependent) [3];
SF the autoinhibitory exon VII domain of c-Ets-1 is required for direct in vitro interactions with HIF-2alpha [10];
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CP T-cells (predom.); thymocytes, bursal lymphocytes [9].
XX
FF activator [11] [7] [1] [2];
FF stronger activator than p54 splice variant [1];
FF functional cooperation with AP-1 at some promoters [7] [1];
FF levels decrease after T cell induction;
FF association with MafB T01433 causes inhibition of erythroid differentiation [8];
FF regulates endothelial-specific gene expression synergistically with HIF-2alpha [10] [11];
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IN T02719 HIF2A; mouse, Mus musculus.
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MX M00743 V$CETS168_Q6.
MX M08881 V$ETSLIKE_Q4.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R39496.
BS R02386.
BS R02153.
BS R01711.
BS R02414.
BS R02415.
BS R02099.
BS R04065.
BS R14471.
BS R14472.
BS R01155.
BS R02232.
BS R74011.
BS R74012.
BS R02097.
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DR TRANSPATH: MO000024716.
DR TRANSCOMPEL: C00131.
DR TRANSCOMPEL: C00236.
DR TRANSCOMPEL: C00265.
DR TRANSCOMPEL: C00408.
DR TRANSCOMPEL: C00409.
DR EMBL: M20507;
DR EMBL: M20508;
DR EMBL: M20509;
DR EMBL: M20510;
DR EMBL: M20511;
DR EMBL: M20512;
DR EMBL: M20513;
DR EMBL: M20514;
DR EMBL: M20515;
DR EMBL: M29515;
DR UniProtKB: P15062;
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RN [1]; RE0000478.
RX PUBMED: 1850695.
RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B.
RT The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins
RL EMBO J. 10:1127-1134 (1991).
RN [2]; RE0000479.
RX PUBMED: 2209540.
RA Bosselut R., Duvall J. F., Gegonne A., Bailly M., Hemar A., Brady J., Ghysdael J.
RT The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1
RL EMBO J. 9:3137-3144 (1990).
RN [3]; RE0000480.
RX PUBMED: 3136014.
RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J.
RT Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins
RL EMBO J. 7:977-983 (1988).
RN [4]; RE0000562.
RX PUBMED: 1311254.
RA Lim F., Kraut N., Frampton J., Graf T.
RT DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism
RL EMBO J. 11:643-652 (1992).
RN [5]; RE0000614.
RX PUBMED: 2163347.
RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J.
RT Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus
RL Genes Dev. 4:667-679 (1990).
RN [6]; RE0000799.
RX PUBMED: 1592263.
RA Wasylyk C., Kerckaert J.-P., Wasylyk B.
RT A novel modulator domain of Ets transcription factors
RL Genes Dev. 6:965-974 (1992).
RN [7]; RE0001866.
RX PUBMED: 2114554.
RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D.
RT The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
RL Nature 346:191-193 (1990).
RN [8]; RE0004908.
RX PUBMED: 8620536.
RA Sieweke M. H., Tekotte H., Frampton J., Graf T.
RT MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
RL Cell 85:49-60 (1996).
RN [9]; RE0005308.
RX PUBMED: 3006066.
RA Ghysdael J., Gegonne A., Pognonec P., Dernis D., Leprince D., Stehelin D.
RT Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene encoded Mr 54,000 cytoplasmic protein
RL Proc. Natl. Acad. Sci. USA 83:1714-1718 (1986).
RN [10]; RE0023729.
RX PUBMED: 12464608.
RA Elvert G., Kappel A., Heidenreich R., Englmeier U., Lanz S., Acker T., Rauter M., Plate K., Sieweke M., Breier G., Flamme I.
RT Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
RL J. Biol. Chem. 278:7520-7530 (2003).
RN [11]; RE0023734.
RX PUBMED: 11049987.
RA Kappel A., Schlaeger T. M., Flamme I., Orkin S. H., Risau W., Breier G.
RT Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.
RL Blood 96:3078-3085 (2000).
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