AC T01433
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ID T01433
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DT 10.04.1995 (created); ewi.
DT 05.03.2007 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA MafB
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SY MAFB.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G037191 MAFB.
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CL C0008; bZIP; 1.1.3.1.3.
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SF no heterodimerization with c-Jun (contrast to v-Maf) [1];
SF binds to TRE-type and CRE-type elements with equal affinity [1];
SF DNA-binding specificity differs from that of AP-1 in that it also recognizes tTactAa [1];
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CP brain, thymus, lung, gut, mesenterium, spleen, kidney, ovary, bursa (high); stomach, liver, testis (marginal) [1].
CN pancreas [1].
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FF relatively weak transcriptional activator (compared with v-Maf), but nearly the same transforming activity [1];
FF interacts with the DNA-binding domain of c-Ets-1 thereby repressing trans-activation by this factor [2];
FF therefore, MafB inhibits erythroid differentiation [2];
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IN T00114 c-Ets-1 54; chick, Gallus gallus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T01433 MafB; chick, Gallus gallus.
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MX M01227 V$MAFB_01.
MX M03830 V$MAFB_Q4.
MX M08888 V$MAFB_Q4_01.
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
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BS R18177.
BS R18188.
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DR TRANSPATH: MO000025664.
DR UniProtKB: Q90888; Q90888.
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RN [1]; RE0004906.
RX PUBMED: 7935473.
RA Kataoka K., Fujiwara K. T., Noda M., Nishizawa M.
RT MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun
RL Mol. Cell. Biol. 14:7581-7591 (1994).
RN [2]; RE0004908.
RX PUBMED: 8620536.
RA Sieweke M. H., Tekotte H., Frampton J., Graf T.
RT MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
RL Cell 85:49-60 (1996).
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