AC T00114
XX
ID T00114
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DT 26.10.1992 (created); ewi.
DT 13.07.2012 (updated); sup.
CO Copyright (C), QIAGEN.
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FA c-Ets-1 54
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SY c-Ets-1; c-Ets-1 54; Ets1; p54; p54c-Ets-1.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G045516 ETS1.
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CL C0016; ETS; 3.5.2.1.1.
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SF negative net charge (-10) of the trans-activation domain [4];
SF phosphorylation (Ca-dependent) [2];
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CP T-cells (predom.); lymphoid cells [7]: thymocytes, bursal lymphocytes [7] [7].
CN low in bone marrow, erythroblasts, fibroblasts, macrophages [7].
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FF activator;
FF functional cooperation with AP-1 [3] [1];
FF functional cooperation with Sp1 [6];
FF in some cases, repression of AP-1 effects have been reported, depending on the C-terminal repressing domain [9];
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IN T01433 MafB; chick, Gallus gallus.
IN T02202 MafB; Japanese quail, Coturnix coturnix japonica.
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MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M01870 V$CETS1_Q6.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
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BS R05581.
BS R05582.
BS R05583.
BS R05584.
BS R05585.
BS R05586.
BS R05587.
BS R05588.
BS R05589.
BS R05590.
BS R05591.
BS R05592.
BS R05593.
BS R05594.
BS R05595.
BS R06122.
BS R06123.
BS R06124.
BS R06125.
BS R06126.
BS R06127.
BS R06128.
BS R06129.
BS R06130.
BS R06131.
BS R06132.
BS R06133.
BS R06134.
BS R06135.
BS R06136.
BS R06137.
BS R06138.
BS R06139.
BS R06140.
BS R06141.
BS R06142.
BS R06143.
BS R06144.
BS R06145.
BS R06146.
BS R06147.
BS R06148.
BS R06149.
BS R06150.
BS R06151.
BS R06152.
BS R06153.
BS R06154.
BS R06155.
BS R06156.
BS R06157.
BS R06158.
BS R06159.
BS R06160.
BS R06161.
BS R26589.
BS R04547.
BS R04707.
BS R02153.
BS R73988.
BS R26588.
BS R73992.
BS R73871.
BS R73955.
BS R02232.
XX
DR TRANSPATH: MO000024715.
DR TRANSCOMPEL: C00020.
DR TRANSCOMPEL: C00131.
DR TRANSCOMPEL: C00185.
DR TRANSCOMPEL: C00233.
DR TRANSCOMPEL: C00240.
DR UniProtKB: P13474;
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RN [1]; RE0000478.
RX PUBMED: 1850695.
RA Wasylyk C., Gutman A., Nicholson R., Wasylyk B.
RT The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins
RL EMBO J. 10:1127-1134 (1991).
RN [2]; RE0000480.
RX PUBMED: 3136014.
RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J.
RT Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins
RL EMBO J. 7:977-983 (1988).
RN [3]; RE0001866.
RX PUBMED: 2114554.
RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D.
RT The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
RL Nature 346:191-193 (1990).
RN [4]; RE0001948.
RX PUBMED: 1515415.
RA Gegonne A., Punyammalee B., Rabault B., Bosselut R., Seneca S., Crabeel M., Ghysdael J.
RT Analysis of the DNA binding and transcriptional activation properties of the Ets1 oncoprotein
RL New Biol. 4:512-519 (1992).
RN [5]; RE0002584.
RX PUBMED: 1409581.
RA Hagman J., Grosschedl R.
RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene
RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992).
RN [6]; RE0005307.
RX PUBMED: 8458329.
RA Gegonne A., Bosselut R., Bailly R.-A., Ghysdael J.
RT Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1
RL EMBO J. 12:1169-1178 (1993).
RN [7]; RE0005308.
RX PUBMED: 3006066.
RA Ghysdael J., Gegonne A., Pognonec P., Dernis D., Leprince D., Stehelin D.
RT Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene encoded Mr 54,000 cytoplasmic protein
RL Proc. Natl. Acad. Sci. USA 83:1714-1718 (1986).
RN [8]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [9]; RE0005317.
RX PUBMED: 8206973.
RA Goldberg Y., Treier M., Ghysdael J., Bohmann D.
RT Repression of AP-1 stimulated transcription by c-Ets-1
RL J. Biol. Chem. 269:16566-16573 (1994).
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