AC T04666
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ID T04666
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DT 20.08.2001 (created); vma.
DT 29.07.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HIF-1alpha
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SY HIF1alpha; hypoxia-inducible factor 1alpha; member of PAS superfamily 1; MOP1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005178 Hif1a.
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CL C0010; bHLH; 1.2.5.1.5.
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CP Deferoxamine mesylate (DFX) treated distal tubular (DT) cells [4].
CN Doxycycline-treated primary tubular epithelial cells (PTCs) [4].
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IN T01797 arnt; mouse, Mus musculus.
IN T30574 Period1; mouse, Mus musculus.
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MX M00976 V$AHRHIF_Q6.
MX M07384 V$HIF1A_Q3.
MX M07043 V$HIF1A_Q5.
MX M02012 V$HIF1A_Q6.
MX M00797 V$HIF1_Q3.
MX M00466 V$HIF1_Q5.
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BS R28622.
BS R29559.
BS R28621.
BS R40949.
BS R40950.
BS R24274.
BS R31278.
BS R10350.
BS R60552.
BS R31392.
BS R60946.
BS R60947.
BS R65424.
BS R65430.
BS R57833.
BS R68457.
BS R65426.
BS R65432.
BS R22336.
BS R22337.
BS R35543.
BS R22294.
BS R66437.
BS R31376.
BS R65663.
BS R62186.
BS R62356.
BS R56138.
BS R56141.
BS R58179.
BS R58180.
BS R58181.
BS R66526.
BS R66527.
BS R13221.
BS R69004.
BS R69005.
BS R69006.
BS R69007.
BS R69009.
BS R69012.
BS R69013.
BS R69001.
BS R69002.
BS R69003.
BS R69023.
BS R67230.
BS R67234.
BS R66342.
BS R66343.
BS R66344.
BS R38291.
BS R27978.
BS R37904.
BS R60974.
BS R37848.
BS R56785.
BS R65564.
BS R66315.
BS R65545.
BS R60876.
BS R67238.
BS R62931.
BS R30340.
BS R62933.
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DR TRANSPATH: MO000028489.
DR UniProtKB: Q61221;
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RN [1]; RE0034409.
RX PUBMED: 12939282.
RA Kunz M., Moeller S., Koczan D., Lorenz P., Wenger R. H., Glocker M. O., Thiesen H. J., Gross G., Ibrahim S. M.
RT Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.
RL J. Biol. Chem. 278:45651-60 (2003).
RN [2]; RE0035766.
RX PUBMED: 15567065.
RA Salem Y., Shpungin S., Pasder O., Pomp O., Taler M., Malovani H., Nir U.
RT Fer kinase sustains the activation level of ERK1/2 and increases the production of VEGF in hypoxic cells.
RL Cell. Signal. 17:341-353 (2005).
RN [3]; RE0046853.
RX PUBMED: 10799651.
RA Kim J. E., Sheen Y. Y.
RT Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents
RL Biochem. Pharmacol. 59:1549-56 (2000).
RN [4]; RE0050880.
RX PUBMED: 15315937.
RT Hypoxic induction of Ctgf is directly mediated by Hif-1
RL Am. J. Physiol. Renal Physiol. 287:1223-1232 (2004).
RN [5]; RE0066620.
RX PUBMED: 17826745.
RA Friedman E. R., Fan C. M.
RT Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.
RL Biochem. Biophys. Res. Commun. 363:113-118 (2007).
RN [6]; RE0066737.
RX PUBMED: 19648120.
RA Mahimainathan L., Ghosh-Choudhury N., Venkatesan B., Das F., Mandal C. C., Dey N., Habib S. L., Kasinath B. S., Abboud H. E., Ghosh Choudhury G.
RT TSC2 deficiency increases PTEN via HIF1alpha.
RL J. Biol. Chem. 284:27790-27798 (2009).
RN [7]; RE0067814.
RX PUBMED: 16286658.
RA Neumann A. K., Yang J., Biju M. P., Joseph S. K., Johnson R. S., Haase V. H., Freedman B. D., Turka L. A.
RT Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.
RL Proc. Natl. Acad. Sci. USA 102:17071-17076 (2005).
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